DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus81 and mus81

DIOPT Version :9

Sequence 1:	NP_569873.1	Gene:	mus81 / 31044	FlyBaseID:	FBgn0040347	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	XP_005172268.1	Gene:	mus81 / 406839	ZFINID:	ZDB-GENE-040426-2923	Length:	612	Species:	Danio rerio

Alignment Length:	590	Identity:	160/590 - (27%)
Similarity:	244/590 - (41%)	Gaps:	178/590 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PNPLFTRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRGFGGTLCQLIDEEL 76
            |||||.:||......|:.:..|:||..::|:.|||.|||||.:|::..||:.||..:|:::||.|
Zfish    18 PNPLFLQWLTELRDSAKEKGLKTQFVYQKAINSLKKYPLPLKNGKEAKILQNFGDGICKILDERL 82

  Fly    77 -RHHR------GLQLLP--------------------------------------------QEAV 90
             :|:|      .:.|.|                                            :|.|
Zfish    83 QKHYRENGPDAPVHLAPSCHWNNMASSKQMEESQKEPLGNFSEHTKLTQKEVRKEKGAKKKREYV 147

  Fly    91 VQER-----------------------YEQQVQAVVRKVQEKQLE-----------------HQK 115
            .|:|                       :..::|...:.:.||...                 .||
Zfish   148 PQKRSGGYAVLLTLYRHIQMPGSKGFMFRNELQTEAQPLCEKSFTVPDLGSKYTAWSSVSTLIQK 212

  Fly   116 RQNKCDRPRKLTKKD----LAELAALEER------------ERVV-------------------- 144
            ...|...|.:.:..|    |||....||.            :.||
Zfish   213 ELVKTHNPARYSLTDQGLSLAEKLDSEETGTLHEDVDSQDGQNVVDLTLEEEDEDEEKESWSSER 277

  Fly   145 -----------------------------------RMKPGQFQLLLLVDTQETSGKNKRVLDQTR 174
                                               .:.||.:.::|.||..||:|.:.....:..
Zfish   278 PAVALPVNQARGLSSELDPMGKSQTSETGRTAMGWHLSPGSYDIVLCVDLCETTGGSSVRKQELV 342

  Fly   175 SYLESLGARHEVRRLTIGDFLWVAQDQ-----------EGNELVLPYIVERKRMDDLASSIRDGR 228
            ..|:......:||:|.:|||||||:::           .|.||||.||:||||||||..||.|||
Zfish   343 KELQRNSVTFDVRKLNVGDFLWVARERVTPVPGQLRPPVGKELVLDYIIERKRMDDLCGSIIDGR 407

  Fly   229 FHEQKHRLQHCGLQHIIYLVEDYGD-NEQLGLPLDSLQQALTNAKVQTGVRVVRTANHYRSMSYL 292
            |.|||.||:.|||:..|||||:.|. ...|.:|..:||||:.|.:|..|..|.|..:...|.:||
Zfish   408 FREQKFRLKRCGLRKPIYLVEECGSAAAHLSIPESTLQQAIVNTQVVDGFFVKRVQDAKESAAYL 472

  Fly   293 AGMSRTLGQIFAGKKL----HSVDRGAIDQSTCLLTHSDLGLLKFRALYEDSAKNAQLTVREVFV 353
            ..|:|.|.:::....|    ..::.....:|..::.:....|:.|......:.||...||||||.
Zfish   473 TIMTRYLQKLYQNCTLFCRSRELEGDGEAESEKMVANLSCSLMAFTEFNYGAIKNKCQTVREVFA 537

  Fly   354 QQLLQLHSLSLERAMAIVERYPTPRWLLDAYAECADQKQARLLLASIPCGPLERPLGDKISQCLH 418
            :||:|:..:|.::|.|::|.|.|...||.||.:|:.:.:...||:|:..|.|:|.||..:|:.::
Zfish   538 RQLMQISGVSGDKAAAVLEHYSTVSSLLQAYDKCSSETEKEKLLSSVKYGKLKRNLGPALSRTIY 602

  Fly   419 EFYST 423
            :.|.|
Zfish   603 QLYCT 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:299849	33/153 (22%)
mus81	NP_569873.1	ERCC4	157..295	CDD:280828	65/149 (44%)
mus81	XP_005172268.1	NT_Pol-beta-like	44..>85	CDD:299849	18/41 (44%)
mus81	XP_005172268.1	ERCC4	325..475	CDD:280828	36/105 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583857
Domainoid	1	1.000	105	1.000	Domainoid score	I6618
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5725
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52011
OrthoDB	1	1.010	-	-		D470169at33208
OrthoFinder	1	1.000	-	-		FOG0003734
OrthoInspector	1	1.000	-	-		oto40965
orthoMCL	1	0.900	-	-		OOG6_103117
Panther	1	1.100	-	-	LDO	PTHR13451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R782
SonicParanoid	1	1.000	-	-		X2590
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.750