DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus81 and mus-81

DIOPT Version :9

Sequence 1:	NP_569873.1	Gene:	mus81 / 31044	FlyBaseID:	FBgn0040347	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_491341.1	Gene:	mus-81 / 172027	WormBaseID:	WBGene00016602	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	470	Identity:	104/470 - (22%)
Similarity:	200/470 - (42%)	Gaps:	104/470 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NPLFTRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRGFGGTLCQLIDE--- 74
            |..|.:.|:  .:..|:.::|.::.|.:|.|:|:..|..:.:..|...::|.|..:...::|
Worm    17 NTFFEKVLK--FQHQEQEDRKLKYVLHKAHENLRKCPFEILTIVDLKNVQGIGENIALKLEETWN 79

  Fly    75 -ELRHHRGLQLLPQEAVVQ----------ERYEQQVQAVVRKVQE-KQLEHQKR-------QNKC 120
             ..|.:.|     |:..::          .|:....::...:::: |:||.||.       :|:.
Worm    80 VACRENNG-----QDPTLRSIKKFTTDDYRRFLTNRKSTTERMKDAKRLEKQKSTKTIVDIENEF 139

  Fly   121 DRPRKLTKKDLAELAALEE-------RERVVRMKPG-------------------QFQLL----- 154
            :......|:....|...:.       :..::|.:.|                   .|:||
Worm   140 ESDGDDDKQPSVPLTKTKSFQVSKPVQPSLIRSQSGNLSSSSSTSSSSSNSSDPLSFRLLTCRPF 204

  Fly   155 ------LLVDTQETSGKNKRVLDQTRSYLESLGARHEVRRLTIGDFLWVAQDQEGNELVLPYIVE 213
                  |:.|.:| ...|.|........::....|.::|.|::||::|:.:..:|.|:|:.::||
Worm   205 EQPTVYLIADNRE-HRNNPRFKSVIEHLVKKEDIRVDIRSLSVGDYIWICRKIDGTEIVMDWVVE 268

  Fly   214 RKRMDDLASSIRDGRFHEQKHRLQHCGLQHIIYLVE--DYGDNEQLGLPLDSLQQALTNAKVQTG 276
            ||..|||.||||.||:.|||.||....:::.:||:|  ..||        .:.:||:.:.....|
Worm   269 RKTWDDLQSSIRGGRYDEQKGRLNMAPMKNRVYLIEAQHKGD--------VACEQAVASTLSNGG 325

  Fly   277 VRVVRTANHYRSMSYLAGMSRTLGQIFAGKKLHSVDRGAIDQSTCLLTHSDLGLLKFRALYEDSA 341
            ..:.|.::...:.::|..::           :...::.||:         ::..:.|..|.....
Worm   326 YLIQRCSDTRDTAAFLKEVT-----------IRLQNKAAIE---------EISGVPFSQLQNLLQ 370

  Fly   342 KNAQLTVREVFVQQLLQLHSLSLERAMAIVERYPTPRWLLDAYAECADQKQARLLLASIPCGPLE 406
            |....||:|.:|:||:....:|..||.||.:|:|:...||..:....|....| ||..:|  .|.
Worm   371 KKKAETVKEAWVRQLMVCPGMSQNRAEAIADRFPSMVSLLSYFRANGDDAPIR-LLQLLP--QLT 432

  Fly   407 RPLGDKISQCLHEFY 421
            ||    |::.|.:|:
Worm   433 RP----ITRNLFKFF 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:299849	17/93 (18%)
mus81	NP_569873.1	ERCC4	157..295	CDD:280828	41/139 (29%)
mus-81	NP_491341.1	ERCC4	214..342	CDD:376909	40/136 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161128
Domainoid	1	1.000	72	1.000	Domainoid score	I6106
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I3679
Isobase	1	0.950	-	0	Normalized mean entropy	S3470
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D470169at33208
OrthoFinder	1	1.000	-	-		FOG0003734
OrthoInspector	1	1.000	-	-		oto18296
orthoMCL	1	0.900	-	-		OOG6_103117
Panther	1	1.100	-	-	LDO	PTHR13451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R782
SonicParanoid	1	1.000	-	-		X2590
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880