DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus81 and Fancm

DIOPT Version :9

Sequence 1:	NP_569873.1	Gene:	mus81 / 31044	FlyBaseID:	FBgn0040347	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_849243.2	Gene:	Fancm / 104806	MGIID:	2442306	Length:	2021	Species:	Mus musculus

Alignment Length:	318	Identity:	71/318 - (22%)
Similarity:	113/318 - (35%)	Gaps:	88/318 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RYEQQVQ-----AVVRKVQEKQLEHQK-------------RQNKCDRPRKLTKKDLAE------- 133
            |...|||     ||.|.:..|...|.|             |:...:.|.:| |.|..|
Mouse  1691 RQRLQVQPSITDAVPRTLNVKAQSHNKIKSASPPCTGVESRKEYGNHPVQL-KADSQEHSDTSAA 1754

  Fly   134 ------LAALEERERVVRMKPGQFQLLLLVDTQE-TSGKNKRVLDQTRSYLESLGARHEVRRLTI 191
                  |...|.......::.|. :..:|||::| |:|     |:...|.....|.:.|:..|..
Mouse  1755 PCSTSLLHVAEGHTAPRHLQEGN-RACILVDSREITTG-----LEVISSLRTVHGLQVEICPLNG 1813

  Fly   192 GDFLWVAQDQEGNELVLPYIVERKRMDDLASSIRDGRFHEQKHRLQHCGLQHIIYLVEDYGDNEQ 256
            .|::..::          .:|.|:...::.|:....:|.||..|||.. .|.|..:||.  |.|:
Mouse  1814 CDYIVSSR----------MVVVRRSQSEMLSNTSKNKFIEQMQRLQSM-FQRICVIVEK--DREK 1865

  Fly   257 LG---------LPLDSLQQALTNAKVQTGVRVVRTANHYRSMSYLAGMSRTLGQIFAGKKLHSVD 312
            .|         ...|||..||..|    |:|::.::....:...|..:|....:..||..:.:|
Mouse  1866 AGDTSKKFRRTKCYDSLLTALVGA----GIRILFSSGQEETADLLKELSLVEQRKNAGIHIPAV- 1925

  Fly   313 RGAIDQSTCLLTHSDLGLLKFRALYEDSAKNAQLTVREV-FVQQLLQLHSLSLERAMA 369
                      |..|.|..|.|           .|::..: ::..|...|..|..:.||
Mouse  1926 ----------LNTSKLEALPF-----------YLSIPGISYITALNMCHQFSSVKKMA 1962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:299849	1/1 (100%)
mus81	NP_569873.1	ERCC4	157..295	CDD:280828	36/147 (24%)
Fancm	NP_849243.2	MPH1	71..610	CDD:224036
		DEXDc	94..236	CDD:238005
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	202..205
		FANCM_ID	287..401	CDD:277190
		Helicase_C	457..564	CDD:278689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..657
		FANCM-MHF_bd	657..769	CDD:293388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..886
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1002..1049
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1273
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1319
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1369..1441
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1447..1466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1615..1700		4/8 (50%)
		Interaction with FAAP24. /evidence=ECO:0000250\|UniProtKB:Q8IYD8	1689..2009		71/318 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1732		2/19 (11%)
		MUS81	1764..1999	CDD:224859	54/244 (22%)
		ERCC4	1783..1909	CDD:280828	36/147 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900