DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3704 and NPA3

DIOPT Version :9

Sequence 1:	NP_569872.1	Gene:	CG3704 / 31043	FlyBaseID:	FBgn0040346	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_012606.3	Gene:	NPA3 / 853535	SGDID:	S000003833	Length:	385	Species:	Saccharomyces cerevisiae

Alignment Length:	381	Identity:	158/381 - (41%)
Similarity:	226/381 - (59%)	Gaps:	49/381 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILVLGMAGSGKTTFTQKLIQHAQ-EKFNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLG 89
            |:.:||||||||||.|:|..|.: ||..|||:|||||...|||.|::||||::.|::||:.||||
Yeast     6 IICIGMAGSGKTTFMQRLNSHLRAEKTPPYVINLDPAVLRVPYGANIDIRDSIKYKKVMENYQLG 70

  Fly    90 PNGGIVTALNMFTTKMAQFAELVRRAGERGHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTI 154
            |||.|||:||:|:||:.|...||.:..::... |:||||||||.|.|||||:||||..|:.|||:
Yeast    71 PNGAIVTSLNLFSTKIDQVIRLVEQKKDKFQN-CIIDTPGQIECFVWSASGAIITESFASSFPTV 134

  Fly   155 VVYVMDVERSACPTTFMSNMLYACSILYKTRLPFLVALNKIDLKDCGFVMDWMTDFEAFQEAQEE 219
            :.|::|..|::.||||||||||||||||||:||.:|..||.|:....|..:||||||:||.|.:|
Yeast   135 IAYIVDTPRNSSPTTFMSNMLYACSILYKTKLPMIVVFNKTDVCKADFAKEWMTDFESFQAAIKE 199

  Fly   220 EH----------SFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKILESVDEYETDYK 274
            :.          .::|:|..:|||.|:.||..|...|||:.||.||.:.:..:.:.||||:..||
Yeast   200 DQDLNGDNGLGSGYMSSLVNSMSLMLEEFYSQLDVVGVSSFTGDGFDEFMQCVDKKVDEYDQYYK 264

  Fly   275 PVYE-----KKRQERLAESATGPKPVDHVEEDGHAVPLGLSLQDPPPHTGNSIFLMAPSLVPESA 334
            ...|     ||::|.:.:.    |.::.:.:|     |||:.:.....:.|.
Yeast   265 QEREKALNLKKKKEEMRKQ----KSLNGLMKD-----LGLNEKSSAAASDND------------- 307

  Fly   335 EIEDEEEMEEDAKGTAEEQNFHSFVQNHLTAQQSKRDK----------LQQEQEQA 380
            .|:...::||||.....:::....|:...|....:|.|          ||:..::|
Yeast   308 SIDAISDLEEDANDGLVDRDEDEGVEREYTFPGEERTKGEVNENSAPDLQRRYQEA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3704	NP_569872.1	Gem1	24..199	CDD:224025	103/173 (60%)
CG3704	NP_569872.1	ATP_bind_1	28..268	CDD:281079	130/250 (52%)
NPA3	NP_012606.3	GPN1	5..254	CDD:349779	130/248 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346746
Domainoid	1	1.000	262	1.000	Domainoid score	I303
eggNOG	1	0.900	-	-		E1_KOG1532
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5257
Inparanoid	1	1.050	276	1.000	Inparanoid score	I577
Isobase	1	0.950	-	0	Normalized mean entropy	S522
OMA	1	1.010	-	-		QHG54774
OrthoFinder	1	1.000	-	-		FOG0005260
OrthoInspector	1	1.000	-	-		oto100338
orthoMCL	1	0.900	-	-		OOG6_101544
Panther	1	1.100	-	-	LDO	PTHR21231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R835
SonicParanoid	1	1.000	-	-		X3783
TreeFam	1	0.960	-	-
	16	15.740