DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRAM and zgc:113278

DIOPT Version :9

Sequence 1:	NP_001245456.1	Gene:	TRAM / 31042	FlyBaseID:	FBgn0040340	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001014363.1	Gene:	zgc:113278 / 541528	ZFINID:	ZDB-GENE-050327-66	Length:	374	Species:	Danio rerio

Alignment Length:	390	Identity:	154/390 - (39%)
Similarity:	221/390 - (56%)	Gaps:	48/390 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGRKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGE-DPSRE 70
            :|.:..||:||:||||||||||||::|||||:.::|||.|.||.||..||::.:||:.. |...|
Zfish     1 MGFRKKNKSPPVLSHEFVIQNHADMVSCVAMIILLGLMFEVTAKFAIMFITVQYNVTQSLDTDVE 65

  Fly    71 QPYGKP-----YTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQ 130
            .   ||     |.|  |.||...:|||.|..||:||:|||::||||:::|||||.|.::||||||
Zfish    66 D---KPDPVNFYKY--GAKDIATVFFYLLIAIILHALIQEYILDKINRRLHLSKTKHSKFNESGQ 125

  Fly   131 LVAFYLLSFVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQKIK 195
            |..|||.||:||..:|..|.::.....||||:|...|:|..||:::.|:||:.|.||||||||:
Zfish   126 LATFYLFSFIWGCSILTNEDFVMNPTFLWEGYPHIHMAFQVKFFYICQIAYWFHALPELYFQKV- 189

  Fly   196 TKEEQQPKIVHSISGFTL-IVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLR 259
             ::|..|:.::.|..:.. |..||.|:..||.||||..||..|||.|..:|.  :..:|...|..
Zfish   190 -RKEDIPRQLYYIGLYIFHITGAYVLNLHRLGLVLLVPHYLVELLFHASRLF--YFSDENKQKGF 251

  Fly   260 VVNNAVFFLIRFATSVIGVLTLYYGIGGVRS----------------LLALGGLIALQGYLVFSF 308
            .:...:|.:.|..|..:.|||..:|:....:                :..|..:...|.::|:.|
Zfish   252 TLWALLFVITRLLTLTVSVLTFGFGLSRTDNQGFSLAEGNFNVLTVRMTCLSAICLTQAWMVWKF 316

  Fly   309 ITEQLRAKREAKKEAKREAKLALQTKKPAKTPKDKVKRKKESD-------LPEADQTSPSPIKQK 366
            |..||:..||   :::.:|     :||...:||.: ..||||.       :...|:|||...|.|
Zfish   317 INFQLKKWRE---QSQIQA-----SKKKTVSPKSR-PSKKESRGGSVNGVMKPDDKTSPRARKSK 372

Fly 367 366
Zfish 373 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRAM	NP_001245456.1	TRAM1	52..121	CDD:285576	34/74 (46%)
TRAM	NP_001245456.1	TLC	124..290	CDD:214789	66/166 (40%)
zgc:113278	NP_001014363.1	TRAM1	46..116	CDD:285576	34/74 (46%)
zgc:113278	NP_001014363.1	TRAM_LAG1_CLN8	119..317	CDD:281751	69/201 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583980
Domainoid	1	1.000	130	1.000	Domainoid score	I5166
eggNOG	1	0.900	-	-		E1_KOG1608
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134165
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3058
OMA	1	1.010	-	-		QHG49031
OrthoDB	1	1.010	-	-		D496777at33208
OrthoFinder	1	1.000	-	-		FOG0002124
OrthoInspector	1	1.000	-	-		otm26030
orthoMCL	1	0.900	-	-		OOG6_106426
Panther	1	1.100	-	-	O	PTHR12371
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1077
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770