DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRAM and Tram1

DIOPT Version :9

Sequence 1:	NP_001245456.1	Gene:	TRAM / 31042	FlyBaseID:	FBgn0040340	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001007702.1	Gene:	Tram1 / 312903	RGDID:	1359100	Length:	374	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	162/388 - (41%)
Similarity:	222/388 - (57%)	Gaps:	36/388 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAIKPGLGRKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGE 65
            |||     ||.||||||:||||||:||||||:||:||:|::|||.|.||..|..|::|.:||: .
  Rat     1 MAI-----RKKSNKNPPVLSHEFVLQNHADIVSCLAMLFLLGLMFEITAKGAIIFVALQYNVT-R 59

  Fly    66 DPSREQPYGKPYTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQ 130
            ..:.||.......|..||||...:|||.|..||:||||||:|||||::::|.||.|.::||||||
  Rat    60 PATEEQAAESASLYYYGIKDLATVFFYMLVAIIVHAIIQEYVLDKINRRMHFSKTKHSKFNESGQ 124

  Fly   131 LVAFYLLSFVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQKIK 195
            |.||||.:.|||..:|:.|.|:.....||..:|.:.|:|..||:::.||||:||..||||||  |
  Rat   125 LSAFYLFACVWGTFILVSENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWLHAFPELYFQ--K 187

  Fly   196 TKEEQQPKIVHSISGFTL-IVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLR 259
            ||:|..|:.:..|..:.. |..||.|:...|.||||.||||.|.|.|:.:|.  :..:|:..|..
  Rat   188 TKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLF--YFSDEKYQKGF 250

  Fly   260 VVNNAVFFLIRFATSVIGVLTLYYGIG-----------GVRSLLA-----LGGLIALQGYLVFSF 308
            .:...:|.|.|..|.::.|||:.:|:.           |..::||     |..:...|.::::.|
  Rat   251 SLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKF 315

  Fly   309 ITEQLRAKREAKKEAKREAKLALQTKKPAKTPKDKVKRKKESDLPEADQTS---PSPIKQKLK 368
            |..|||..||.........|     :|||.| |.:..||...:......||   .||..:|.|
  Rat   316 INFQLRRWREHSAFQAPPVK-----RKPAVT-KGRSSRKGTENGVNGTVTSNGADSPRSRKEK 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRAM	NP_001245456.1	TRAM1	52..121	CDD:285576	32/68 (47%)
TRAM	NP_001245456.1	TLC	124..290	CDD:214789	70/177 (40%)
Tram1	NP_001007702.1	TRAM1	47..115	CDD:400615	32/68 (47%)
		TLC	117..326	CDD:214789	80/212 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..374		14/46 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343728
Domainoid	1	1.000	120	1.000	Domainoid score	I5614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3109
OMA	1	1.010	-	-		QHG49031
OrthoDB	1	1.010	-	-		D496777at33208
OrthoFinder	1	1.000	-	-		FOG0002124
OrthoInspector	1	1.000	-	-		otm46114
orthoMCL	1	0.900	-	-		OOG6_106426
Panther	1	1.100	-	-	O	PTHR12371
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1077
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910