DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRAM and tram1

DIOPT Version :9

Sequence 1:	NP_001245456.1	Gene:	TRAM / 31042	FlyBaseID:	FBgn0040340	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_705955.2	Gene:	tram1 / 266757	ZFINID:	ZDB-GENE-021011-1	Length:	369	Species:	Danio rerio

Alignment Length:	378	Identity:	163/378 - (43%)
Similarity:	219/378 - (57%)	Gaps:	34/378 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGEDPSREQPY 73
            ||.:.||||:|||||||||||||:|||||||::|||.|.|:..|..||::.:||:  .|:...|.
Zfish     4 RKKTTKNPPVLSHEFVIQNHADIVSCVAMVFLLGLMFEITSKVAVLFITVQYNVT--IPANGGPE 66

  Fly    74 GKPYTYI-AGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQLVAFYLL 137
            .....|. .|:||...||||.|..|||||||||:|||||::|:|.||.|.::|||||||.||||.
Zfish    67 EATVNYFHYGLKDVATIFFYMLVAIIMHAIIQEYVLDKINRKMHFSKTKHSKFNESGQLSAFYLF 131

  Fly   138 SFVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQKIKTKEEQQP 202
            |.:|||.:|:.|..|.....||:|:|...|.|..|||::.||.|:||.:|||||||.| ||:...
Zfish   132 SCLWGASILVSENILSNPVSLWDGYPHTLMQFQMKFYYICQLGYWLHAIPELYFQKAK-KEDIPR 195

  Fly   203 KIVHSISGFTLIVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLRVVNNAVFF 267
            ::|:.......|..||.|:..||.||||.||||.||:.||.:|| .|..|||.:...|.  ||.|
Zfish   196 QLVYISLYLVHIAGAYALNLNRLGLVLLVLHYFVELIFHVSRLI-YFSNEERQSGFTVW--AVLF 257

  Fly   268 LI-RFATSVIGVLTLYYGIGGVRS----------------LLALGGLIALQGYLVFSFITEQLRA 315
            :: |..|..:.|||:.:|:.|...                :..|..:...|.::::.||..|||.
Zfish   258 VLGRLLTLSLSVLTVGFGLAGAEKQGLNLAEGSFNVLFVRVTVLAAICITQAFMMWKFINFQLRR 322

  Fly   316 KREAKKEAKREAKLALQTKKPAKTPKDKVKRKK--ESDLPEADQTSPSPIKQK 366
            .||   :|:.:.     .||.:.:.|.|.|:..  ...:..:...||...|:|
Zfish   323 WRE---QAQTQT-----LKKKSSSSKSKSKKANGVNGSVGASGADSPRARKEK 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRAM	NP_001245456.1	TRAM1	52..121	CDD:285576	34/69 (49%)
TRAM	NP_001245456.1	TLC	124..290	CDD:214789	78/166 (47%)
tram1	NP_705955.2	TRAM1	50..115	CDD:285576	33/66 (50%)
tram1	NP_705955.2	TLC	117..326	CDD:214789	87/215 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583981
Domainoid	1	1.000	130	1.000	Domainoid score	I5166
eggNOG	1	0.900	-	-		E1_KOG1608
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3058
OMA	1	1.010	-	-		QHG49031
OrthoDB	1	1.010	-	-		D496777at33208
OrthoFinder	1	1.000	-	-		FOG0002124
OrthoInspector	1	1.000	-	-		otm26030
orthoMCL	1	0.900	-	-		OOG6_106426
Panther	1	1.100	-	-	O	PTHR12371
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4393
SonicParanoid	1	1.000	-	-		X1077
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800