Protein Alignment TRAM and TRAM1

DIOPT Version :10

• Sequence 1: NP_726710.1
• Gene: TRAM / 31042
• FlyBaseID: FBgn0040340
• Length: 368
• Species: Drosophila melanogaster
• Sequence 2: NP_055109.1
• Gene: TRAM1 / 23471
• HGNCID: 20568
• Length: 374
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 156/387 - (40%)
• Similarity: 218/387 - (56%)
• Gaps: 34/387 - (8%)

  Fly     1 MAIKPGLGRKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGE 65
            |||     ||.|.|:||:||||||:||||||:|||||||::|||.|.||..:..|::|.:||: .
Human     1 MAI-----RKKSTKSPPVLSHEFVLQNHADIVSCVAMVFLLGLMFEITAKASIIFVTLQYNVT-L 59

  Fly    66 DPSREQPYGKPYTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQ 130
            ..:.||.......|..||||...:|||.|..||:||:|||::||||::::|.||.|.::||||||
Human    60 PATEEQATESVSLYYYGIKDLATVFFYMLVAIIIHAVIQEYMLDKINRRMHFSKTKHSKFNESGQ 124

  Fly   131 LVAFYLLSFVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQKIK 195
            |.||||.:.|||..:|:.|.|:.....||..:|.:.|:|..||:::.||||:||..||||||  |
Human   125 LSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWLHAFPELYFQ--K 187

  Fly   196 TKEEQQPKIVHSISGFTL-IVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLR 259
            ||:|..|:.:..|..:.. |..||.|:...|.||||.||||.|.|.|:.:|.  :...|:..|..
Human   188 TKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLF--YFSNEKYQKGF 250

  Fly   260 VVNNAVFFLIRFATSVIGVLTLYYGIG-----------GVRSLLA-----LGGLIALQGYLVFSF 308
            .:...:|.|.|..|.::.|||:.:|:.           |..::||     |..:...|.::::.|
Human   251 SLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICVTQAFMMWKF 315

  Fly   309 ITEQLRAKREAKKEAKREAKLALQTKKPAKTPKDKVKRKKESDL--PEADQTSPSPIKQKLK 368
            |..|||..||.........|     |||..|.....|:..|:.:  ......:.||..:|.|
Human   316 INFQLRRWREHSAFQAPAVK-----KKPTVTKGRSSKKGTENGVNGTLTSNVADSPRNKKEK 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAM	NP_726710.1	TRAM1	52..121	CDD:462460	29/68 (43%)
		TLC	124..290	CDD:214789	70/177 (40%)
TRAM1	NP_055109.1	TRAM1	50..115	CDD:462460	29/65 (45%)
		TLC	117..326	CDD:214789	80/212 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..374		11/44 (25%)