DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRAM and TRAM1L1

DIOPT Version :9

Sequence 1:	NP_001245456.1	Gene:	TRAM / 31042	FlyBaseID:	FBgn0040340	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_689615.2	Gene:	TRAM1L1 / 133022	HGNCID:	28371	Length:	369	Species:	Homo sapiens

Alignment Length:	374	Identity:	138/374 - (36%)
Similarity:	201/374 - (53%)	Gaps:	41/374 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGEDPSREQPY 73
            ||.|.||||:||.||::||||||:|||.|.|::||:.|.||..:..|::|.|:|: ...:.||..
Human     4 RKKSTKNPPVLSQEFILQNHADIVSCVGMFFLLGLVFEGTAEASIVFLTLQHSVA-VPAAEEQAT 67

  Fly    74 GKPYTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQLVAFYLLS 138
            |....|..|:||...:|||.|..||:||.|||:|||||:|::..:|.|..:||||||...||..|
Human    68 GSKSLYYYGVKDLATVFFYMLVAIIIHATIQEYVLDKINKRMQFTKAKQNKFNESGQFSVFYFFS 132

  Fly   139 FVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQKIKTKEEQQPK 203
            .:||..:|:.|..|.....:|:..|...|:|..||:::.||||:.|..||||||  |||::..|:
Human   133 CIWGTFILISENCLSDPTLIWKARPHSMMTFQMKFFYISQLAYWFHAFPELYFQ--KTKKQDIPR 195

  Fly   204 IVHSISGFTL--IVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLRVVNNAVF 266
            .:..| |..|  |..||.|....|.|:||.||||.|||||:..|.  :..:|:..|...:...||
Human   196 QLVYI-GLHLFHITGAYLLYLNHLGLLLLVLHYFVELLSHMCGLF--YFSDEKYQKGISLWAIVF 257

  Fly   267 FLIRFATSVIGVLTLYYGIGGVRS----------------LLALGGLIALQGYLVFSFIT----- 310
            .|.|..|.::.|||:.:.:.|.::                :..|.....:|.|:.::.||
Human   258 ILGRLVTLIVSVLTVGFHLAGSQNRNPDALTGNVNVLAAKIAVLSSSCTIQAYVTWNLITLWLQR 322

  Fly   311 ---------EQLRAKREAKKEAKREAKLALQTKKPAKTPKDKVKRKKES 350
                     ..::.||....:.:.|..:.::|......|.   |||::|
Human   323 WVEDSNIQASCMKKKRSRSSKKRTENGVGVETSNRVDCPP---KRKEKS 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRAM	NP_001245456.1	TRAM1	52..121	CDD:285576	29/68 (43%)
TRAM	NP_001245456.1	TLC	124..290	CDD:214789	67/167 (40%)
TRAM1L1	NP_689615.2	TRAM1	50..115	CDD:369849	29/65 (45%)
		TLC	117..326	CDD:214789	72/213 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..369		9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149839
Domainoid	1	1.000	120	1.000	Domainoid score	I5753
eggNOG	1	0.900	-	-		E1_KOG1608
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3254
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49031
OrthoDB	1	1.010	-	-		D496777at33208
OrthoFinder	1	1.000	-	-		FOG0002124
OrthoInspector	1	1.000	-	-		otm41973
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12371
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1077
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870