DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB48 and CG31365

DIOPT Version :9

Sequence 1:	NP_001265576.1	Gene:	ZBTB48 / 3104	HGNCID:	4930	Length:	688	Species:	Homo sapiens
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	109/535 - (20%)
Similarity:	179/535 - (33%)	Gaps:	195/535 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   101 ELRVPEAVELCQSFKPKTSVGQAAGGQSGLGPPASQNVNSHVKE------PAGLEEEEVSRTLGL 159
            |||.....||.:....:.        :|.:....::.|.|.|::      ...:.:|:::..||.
  Fly   157 ELRAKLTTELRKELAEEV--------RSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLGE 213

Human   160 VP---------RDQEPRGSHSPQRPQLH---SPAQSE-------GPSSLCGKLK--QALKPCPLE 203
            :.         |.:...||....:||:.   ||::|:       .||.:...||  :|.|
  Fly   214 LEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARK----- 273

Human   204 DKKPED----CKVPP---RPLEAEGAQL------QGGSNEWEV------VV-------------- 235
            |.|.|:    |...|   ..:..:|.:|      :.|.:..|:      ||
  Fly   274 DAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDNGEIYIINSAS 338

Human   236 ---------------------QVEDDGD-------------------GDYMSEPEAVLT------ 254
                                 .:::||:                   |:.:|:.:.|.:
  Fly   339 SEDQNQDSTPEFDQDNGITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHENVI 403

Human   255 --------RRKSNVIRKPCAAEPALSAGSLAAEPAENR-KGTAVPVECPTCHKKFLSKYYLKVHN 310
                    |.:...:::..::|......|...:|...| ..|....:|..|...|.::..|..|:
  Fly   404 IVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHH 468

Human   311 RKH-TGEK-----PFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHM 369
            ..| .|.|     ..:||.|                 .:..|        |..:.:|      ||
  Fly   469 NTHIKGLKSGKGGTLKCPSC-----------------ALQLS--------CASSLKR------HM 502

Human   370 VSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEK 434
            :.|||..|:|||.|...|.|::.|:.|| ..|...|.|.||.|:.||..::.||.|....|.|
  Fly   503 IIHTGLKPFKCSECELSFSQREVLKRHM-DTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMG-- 564

Human   435 LFVCEECGHRASSRNGLQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCG 499
                                      |.|.|.|..|..:|...:.|:.||.||.|.. |.|..||
  Fly   565 --------------------------NSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCG 602

Human   500 KTFRTQASLDKHNRT 514
            :.|..::::.:|..|
  Fly   603 RQFNDRSAVQRHVTT 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB48	NP_001265576.1	BTB	16..119	CDD:306997	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..140		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..192		10/49 (20%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		zf-H2C2_2	305..328	CDD:316026	8/28 (29%)
		C2H2 Zn finger	321..372	CDD:275368	8/50 (16%)
		SFP1	<374..459	CDD:227516	24/84 (29%)
		C2H2 Zn finger	380..401	CDD:275368	8/20 (40%)
		C2H2 Zn finger	409..425	CDD:275370	7/15 (47%)
		C2H2 Zn finger	438..459	CDD:275368	0/20 (0%)
		COG5048	<464..612	CDD:227381	17/51 (33%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	495..515	CDD:275368	6/20 (30%)
		C2H2 Zn finger	523..540	CDD:275368
		C2H2 Zn finger	555..572	CDD:275368
		C2H2 Zn finger	580..600	CDD:275368
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	17/94 (18%)
		RRF	<161..222	CDD:294170	9/68 (13%)
		zf-C2H2_8	454..530	CDD:292531	26/106 (25%)
		C2H2 Zn finger	485..505	CDD:275368	8/50 (16%)
		zf-H2C2_2	497..522	CDD:290200	12/30 (40%)
		C2H2 Zn finger	513..533	CDD:275368	8/20 (40%)
		zf-H2C2_2	526..550	CDD:290200	11/24 (46%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910