Protein Alignment Lztr1 and KEL2

DIOPT Version :10

• Sequence 1: NP_001259114.1
• Gene: Lztr1 / 31037
• FlyBaseID: FBgn0040344
• Length: 998
• Species: Drosophila melanogaster
• Sequence 2: NP_011754.3
• Gene: KEL2 / 853153
• SGDID: S000003470
• Length: 882
• Species: Saccharomyces cerevisiae
• Alignment Length: 907
• Identity: 178/907 - (19%)
• Similarity: 309/907 - (34%)
• Gaps: 252/907 - (27%)

  Fly   207 SGSGSGKATSPGSYSCNALNVDFTSYTATHQWTRM-LECAEFVGAKRSKHTVVAYKDAMFVFGGD 270
            ||:.:....||.|.:           |..:.|.|: |:.:.|...:.|...:|...:.:||.||.
Yeast    53 SGASTALPWSPESKN-----------TGKYIWNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGL 106

  Fly   271 NGKNMLNDLIRFGVKDKSWGRAC-ATGT------------PPAPRYHHSAVVAGSSMFIFGGYTG 322
            :.:::..|:         |..|. |.||            .|.||..|::.:.|::..:|||.|.
Yeast   107 HDQSVYGDV---------WQIAANADGTSFTSKRIDIDQNTPPPRVGHASTICGNAYVVFGGDTH 162

  Fly   323 DIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAV-----YDNKMWIYAGYDGNAR 382
            .::.|..|  .:||:.:...|..|...:..||:|:.|..|..::     ...|::::.|......
Yeast   163 KLNKNGLL--DDDLYLFNINSYKWTIPQPIGRRPLGRYGHKISIIASNPMQTKLYLFGGQVDETY 225

  Fly   383 LNDMWTLNLTG----ENQWEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFK 443
            .||:...:|:.    .:.||.::.:||.||...|..:....:.::||.|::...|:|..:.:...
Yeast   226 FNDLVVFDLSSFRRPNSHWEFLEPVGDLPPPLTNHTMVAYDNKLWVFGGETPKTISNDTYRYDPA 290

  Fly   444 TRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGG-SADSTLPNDLHCYDLDSQVWSVI 507
            ...|.::.       .|...|.....|..|.:...:.|.|| ...:...||::..:|.|..|..:
Yeast   291 QSEWSKVK-------TTGEKPPPIQEHASVVYKHLMCVLGGKDTHNAYSNDVYFLNLLSLKWYKL 348

  Fly   508 QPEQNSDVPSGRVFHASAVI-CDAMYIFGG--------------TVDNSVRRGD-TYRFQFSSYP 556
             |.....:|..|..|:..:: .:.:.|.||              |.:.....|. .|....||.
Yeast   349 -PRMKEGIPQERSGHSLTLMKNEKLLIMGGDKTDYASPNIHDLQTSETDQGEGTLLYTLDLSSL- 411

  Fly   557 KCTLRDDFGKFFQDKQFCD---IQFIVGAEEIRILAHIAFVAARSKYLRNKILAAREARQQQMEK 618
                          .:.|.   .:.:...|.........|..::|....|:.:......:....|
Yeast   412 --------------NELCPGIMCESLHAGESFSNSLSGGFTPSKSTESENQEIINILTPRLPDSK 462

  Fly   619 VYGVGQVDALALNAGAGGDRGPMLEVRLANASPEAFEIILNYIYTDRIDLKDTYSK--------- 674
            |.....:|     .|||.....:        ..:|||     ..:||.:.|...||
Yeast   463 VLSYNDID-----EGAGSYSSAL--------DDKAFE-----RKSDREEKKPQSSKVDSSINKES 509

  Fly   675 ---NIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINK-----------LNVLEALYNADKSNIK 725
               .|.:...:...|.|| |:....:|...|.|....|           ||:......|.:..::
Yeast   510 PGTGIKVSKKNFPVLRGL-TVDSEEYGSSSYKDTSCQKGIPKNLFDDLNLNLQTLRLEAQQKELE 573

  Fly   726 IIKDHCMQ--------FIIKE----ENF----------TDVVMSSEFSDLDKPLLVEIIRKRLYP 768
            ..: |..|        .:|||    .||          ....:.|..:||...|:|::.:    .
Yeast   574 TAR-HISQLEKEVQRLMVIKEASKDSNFQTARLKNLEIQKTFLESRINDLKNLLMVKLSQ----A 633

  Fly   769 SKLVIDTSYEGN-IGTTLE--------IDLCAFLESTGKDFCDI----SLVLEDH---VIPAHKS 817
            |||....:.:.| :.|..|        |||        ::.||:    :.:|.::   :.|...:
Yeast   634 SKLCDQITIQNNGLKTCSEHVTIKRDIIDL--------ENKCDVLKRQNEILVNNMQKITPELHT 690

  Fly   818 VLSSRCTYFQGMFRSF----MPPDNTVNIQIGE------ISPSLEAFHSLLRYIYYGETKMPPQD 872
            .|:....|...:.:|:    .||.:..:.||.|      |...:...|..:|
Yeast   691 YLNESSCYLGKLLKSYPTSARPPSSEKDNQIYEKDSLNKIEKVINEMHETVR------------- 742

  Fly   873 ALYLFQAPCFYGLANNRLHAFC------KYSLEHNITFENVLQTLEA----SD-ITKIYDIKEYA 926
                         |..:||...      :.||..|:...|  ..|:|    || .:|..|:.:.|
Yeast   743 -------------AKEKLHLETQKLNDERDSLRANLLDNN--NKLDALRKLSDGSSKSMDLTKKA 792

  Fly   927 LKLIVKDFAKVARLPKIAGLSRELLLEIIRAVAD--------------SHGEF--LTRININ 972
            :.|      ..:.|.|....:.:|..||.|...:              :||.|  ..|:.||
Yeast   793 IHL------SQSELEKYRKNNDDLQKEIDRIKTEQAEQDDKQEQRGAITHGNFDAFHRMKIN 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	NanM	252..551	CDD:442289	72/337 (21%)
		KELCH repeat	252..298	CDD:276965	12/58 (21%)
		KELCH repeat	302..355	CDD:276965	14/52 (27%)
		KELCH repeat	359..407	CDD:276965	11/56 (20%)
		KELCH repeat	410..455	CDD:276965	7/44 (16%)
		KELCH repeat	467..509	CDD:276965	10/42 (24%)
		BTB1_POZ_LZTR1	551..704	CDD:349617	28/167 (17%)
		BACK1_LZTR1	708..766	CDD:350580	16/90 (18%)
		BTB2_POZ_LZTR1	781..906	CDD:349618	26/155 (17%)
		BACK2_LZTR1	902..962	CDD:350581	15/78 (19%)
KEL2	NP_011754.3	NanM	77..391	CDD:442289	71/332 (21%)
		KELCH repeat	142..190	CDD:276965	13/49 (27%)
		KELCH repeat	257..308	CDD:276965	9/57 (16%)
		KELCH repeat	310..353	CDD:276965	11/43 (26%)
		SMC_N	<603..872	CDD:481474	56/292 (19%)