DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lztr1 and KEL2

DIOPT Version :9

Sequence 1:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_011754.3	Gene:	KEL2 / 853153	SGDID:	S000003470	Length:	882	Species:	Saccharomyces cerevisiae

Alignment Length:	907	Identity:	178/907 - (19%)
Similarity:	309/907 - (34%)	Gaps:	252/907 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 SGSGSGKATSPGSYSCNALNVDFTSYTATHQWTRM-LECAEFVGAKRSKHTVVAYKDAMFVFGGD 270
            ||:.:....||.|.:           |..:.|.|: |:.:.|...:.|...:|...:.:||.||.
Yeast    53 SGASTALPWSPESKN-----------TGKYIWNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGL 106

  Fly   271 NGKNMLNDLIRFGVKDKSWGRAC-ATGT------------PPAPRYHHSAVVAGSSMFIFGGYTG 322
            :.:::..|:         |..|. |.||            .|.||..|::.:.|::..:|||.|.
Yeast   107 HDQSVYGDV---------WQIAANADGTSFTSKRIDIDQNTPPPRVGHASTICGNAYVVFGGDTH 162

  Fly   323 DIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAV-----YDNKMWIYAGYDGNAR 382
            .::.|..|  .:||:.:...|..|...:..||:|:.|..|..::     ...|::::.|......
Yeast   163 KLNKNGLL--DDDLYLFNINSYKWTIPQPIGRRPLGRYGHKISIIASNPMQTKLYLFGGQVDETY 225

  Fly   383 LNDMWTLNLTG----ENQWEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFK 443
            .||:...:|:.    .:.||.::.:||.||...|..:....:.::||.|::...|:|..:.:...
Yeast   226 FNDLVVFDLSSFRRPNSHWEFLEPVGDLPPPLTNHTMVAYDNKLWVFGGETPKTISNDTYRYDPA 290

  Fly   444 TRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGG-SADSTLPNDLHCYDLDSQVWSVI 507
            ...|.::.       .|...|.....|..|.:...:.|.|| ...:...||::..:|.|..|..:
Yeast   291 QSEWSKVK-------TTGEKPPPIQEHASVVYKHLMCVLGGKDTHNAYSNDVYFLNLLSLKWYKL 348

  Fly   508 QPEQNSDVPSGRVFHASAVI-CDAMYIFGG--------------TVDNSVRRGD-TYRFQFSSYP 556
             |.....:|..|..|:..:: .:.:.|.||              |.:.....|. .|....||.
Yeast   349 -PRMKEGIPQERSGHSLTLMKNEKLLIMGGDKTDYASPNIHDLQTSETDQGEGTLLYTLDLSSL- 411

  Fly   557 KCTLRDDFGKFFQDKQFCD---IQFIVGAEEIRILAHIAFVAARSKYLRNKILAAREARQQQMEK 618
                          .:.|.   .:.:...|.........|..::|....|:.:......:....|
Yeast   412 --------------NELCPGIMCESLHAGESFSNSLSGGFTPSKSTESENQEIINILTPRLPDSK 462

  Fly   619 VYGVGQVDALALNAGAGGDRGPMLEVRLANASPEAFEIILNYIYTDRIDLKDTYSK--------- 674
            |.....:|     .|||.....:        ..:|||     ..:||.:.|...||
Yeast   463 VLSYNDID-----EGAGSYSSAL--------DDKAFE-----RKSDREEKKPQSSKVDSSINKES 509

  Fly   675 ---NIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINK-----------LNVLEALYNADKSNIK 725
               .|.:...:...|.|| |:....:|...|.|....|           ||:......|.:..::
Yeast   510 PGTGIKVSKKNFPVLRGL-TVDSEEYGSSSYKDTSCQKGIPKNLFDDLNLNLQTLRLEAQQKELE 573

  Fly   726 IIKDHCMQ--------FIIKE----ENF----------TDVVMSSEFSDLDKPLLVEIIRKRLYP 768
            ..: |..|        .:|||    .||          ....:.|..:||...|:|::.:    .
Yeast   574 TAR-HISQLEKEVQRLMVIKEASKDSNFQTARLKNLEIQKTFLESRINDLKNLLMVKLSQ----A 633

  Fly   769 SKLVIDTSYEGN-IGTTLE--------IDLCAFLESTGKDFCDI----SLVLEDH---VIPAHKS 817
            |||....:.:.| :.|..|        |||        ::.||:    :.:|.::   :.|...:
Yeast   634 SKLCDQITIQNNGLKTCSEHVTIKRDIIDL--------ENKCDVLKRQNEILVNNMQKITPELHT 690

  Fly   818 VLSSRCTYFQGMFRSF----MPPDNTVNIQIGE------ISPSLEAFHSLLRYIYYGETKMPPQD 872
            .|:....|...:.:|:    .||.:..:.||.|      |...:...|..:|
Yeast   691 YLNESSCYLGKLLKSYPTSARPPSSEKDNQIYEKDSLNKIEKVINEMHETVR------------- 742

  Fly   873 ALYLFQAPCFYGLANNRLHAFC------KYSLEHNITFENVLQTLEA----SD-ITKIYDIKEYA 926
                         |..:||...      :.||..|:...|  ..|:|    || .:|..|:.:.|
Yeast   743 -------------AKEKLHLETQKLNDERDSLRANLLDNN--NKLDALRKLSDGSSKSMDLTKKA 792

  Fly   927 LKLIVKDFAKVARLPKIAGLSRELLLEIIRAVAD--------------SHGEF--LTRININ 972
            :.|      ..:.|.|....:.:|..||.|...:              :||.|  ..|:.||
Yeast   793 IHL------SQSELEKYRKNNDDLQKEIDRIKTEQAEQDDKQEQRGAITHGNFDAFHRMKIN 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	76/356 (21%)
		KELCH repeat	252..298	CDD:276965	12/58 (21%)
		Kelch_3	261..310	CDD:290151	14/61 (23%)
		Kelch_5	299..>329	CDD:290565	10/29 (34%)
		KELCH repeat	302..355	CDD:276965	14/52 (27%)
		Kelch_1	358..400	CDD:279660	9/50 (18%)
		KELCH repeat	359..407	CDD:276965	11/56 (20%)
		KELCH repeat	410..455	CDD:276965	7/44 (16%)
		Kelch_1	410..452	CDD:279660	7/41 (17%)
		Kelch_1	466..509	CDD:279660	10/43 (23%)
		KELCH repeat	467..509	CDD:276965	10/42 (24%)
		BTB	564..704	CDD:279045	26/154 (17%)
		BTB	575..707	CDD:197585	26/146 (18%)
		SPOP_C_like	707..766	CDD:269810	16/91 (18%)
		BTB	798..898	CDD:279045	18/122 (15%)
		BTB	802..902	CDD:197585	19/122 (16%)
		SPOP_C_like	902..960	CDD:269810	15/62 (24%)
KEL2	NP_011754.3	Kelch_5	82..116	CDD:404696	8/42 (19%)
		PLN02153	139..379	CDD:177814	57/249 (23%)
		KELCH repeat	142..190	CDD:276965	13/49 (27%)
		KELCH repeat	257..308	CDD:276965	9/57 (16%)
		KELCH repeat	310..353	CDD:276965	11/43 (26%)
		Smc	<603..>882	CDD:224117	56/292 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9233
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870