DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lztr1 and LZTR1

DIOPT Version :9

Sequence 1:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_006758.2	Gene:	LZTR1 / 8216	HGNCID:	6742	Length:	840	Species:	Homo sapiens

Alignment Length:	839	Identity:	428/839 - (51%)
Similarity:	560/839 - (66%)	Gaps:	75/839 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SGPGGSGCSMAYDAASNASSGSGSGSGKATSPG---SYSCN----ALNVDFTSYTATHQWTRMLE 243
            :|||.:|..:.  ||:.|     .|:....:|.   .:||:    .|.::|..:...|:|.|:..
Human     2 AGPGSTGGQIG--AAALA-----GGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPP 59

  Fly   244 CAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAV 308
            |.|||||:||||||||||||::||||||||.|||||:||.|||.||.||..||||||||||||||
Human    60 CDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAV 124

  Fly   309 VAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWI 373
            |.|||||:||||||||:|||||.||||||||||.:..|.|||..||.||.||||||.||.:|:||
Human   125 VYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWI 189

  Fly   374 YAGYDGNARLNDMWTLNLTGENQ--WEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNS 436
            :||||||||||||||:.|.....  ||||.|.|:.||:||||||||.||.|:|||||||.:|||:
Human   190 FAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNN 254

  Fly   437 LFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDS 501
            ||:|.||.:||.||..|.:||| :..||.||||||||..||.||||||:||:||||:|||||:|.
Human   255 LFQFEFKDKTWTRIPTEHLLRG-SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDF 318

  Fly   502 QVWSVIQPEQNSDV--------------------------------------------------- 515
            |.|.|:||..:|:|
Human   319 QTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASE 383

  Fly   516 -PSGRVFHASAVICDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQDKQFCDIQFI 579
             ||||:|||:|||.||||||||||||::|.|:.||||||.||||||.:|:|:.::.:||||::|:
Human   384 LPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448

  Fly   580 VGAEEIRILAHIAFVAARSKYLRNKILAAREARQQQMEKVYGVGQVDALALNAGAGGDRGPMLEV 644
            :|.:|..:..|:|.|.|||::||.||..|||...|::|:  ....|...|....|||.|.|:|.|
Human   449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQ--EAAPVPREAPGVAAGGARPPLLHV 511

  Fly   645 RLANASPEAFEIILNYIYTDRIDLKDTYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINK 709
            .:..|....||:::.::|||:|..........::||.|:|:||..|.:.||...|.||::..::.
Human   512 AIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDL 576

  Fly   710 LNVLEALYNADKSNIKIIKDHCMQFIIKEENFTDVVMSSEFSDLDKPLLVEII-RKRLYPSKLVI 773
            .|||....:|.:..:..:|:||:.|::||.:|..|:|..||..|..||:|||: ||:..|.:..:
Human   577 QNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPL 641

  Fly   774 DTSYEGNIGTTLEIDLCAFLESTGKDFCDISLVLEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDN 838
            |...:  |||:|..|:.|:||..|.:||||:|:|:.|..||||::|::|.:||:.|||||||.|.
Human   642 DQPVD--IGTSLIQDMKAYLEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDG 704

  Fly   839 TVNIQIGEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNIT 903
            .|||.|||:.||.:||.|:||||||||..|||:|:||||.||.:||..||||.|:||.:||.|:|
Human   705 QVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVT 769

  Fly   904 FENVLQTLEASDITKIYDIKEYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSH 962
            .:||||.|||:|.|:..|:|.:.|.:||..|.||::||.:..||::|||:||.::| ||
Human   770 VQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLA-SH 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	227/370 (61%)
		KELCH repeat	252..298	CDD:276965	36/45 (80%)
		Kelch_3	261..310	CDD:290151	39/48 (81%)
		Kelch_5	299..>329	CDD:290565	26/29 (90%)
		KELCH repeat	302..355	CDD:276965	41/52 (79%)
		Kelch_1	358..400	CDD:279660	28/43 (65%)
		KELCH repeat	359..407	CDD:276965	32/49 (65%)
		KELCH repeat	410..455	CDD:276965	31/44 (70%)
		Kelch_1	410..452	CDD:279660	30/41 (73%)
		Kelch_1	466..509	CDD:279660	31/42 (74%)
		KELCH repeat	467..509	CDD:276965	30/41 (73%)
		BTB	564..704	CDD:279045	51/139 (37%)
		BTB	575..707	CDD:197585	47/131 (36%)
		SPOP_C_like	707..766	CDD:269810	23/59 (39%)
		BTB	798..898	CDD:279045	61/99 (62%)
		BTB	802..902	CDD:197585	61/99 (62%)
		SPOP_C_like	902..960	CDD:269810	27/57 (47%)
LZTR1	NP_006758.2	PLN02193	<44..223	CDD:330882	126/178 (71%)
		KELCH repeat	68..114	CDD:276965	36/45 (80%)
		Kelch 1. /evidence=ECO:0000255	79..128		38/48 (79%)
		KELCH repeat	118..172	CDD:276965	42/53 (79%)
		Kelch 2. /evidence=ECO:0000255	130..185		41/54 (76%)
		PLN02193	160..>407	CDD:330882	131/247 (53%)
		Kelch 3. /evidence=ECO:0000255	187..238		33/50 (66%)
		Kelch 4. /evidence=ECO:0000255	239..285		27/46 (59%)
		KELCH repeat	284..326	CDD:276965	30/41 (73%)
		Kelch 5. /evidence=ECO:0000255	295..341		25/45 (56%)
		Kelch 6. /evidence=ECO:0000255	399..450		32/50 (64%)
		BTB	433..573	CDD:321966	51/141 (36%)
		SPOP_C_like	574..634	CDD:269810	23/59 (39%)
		BTB	665..753	CDD:306997	54/87 (62%)
		SPOP_C_like	768..>807	CDD:269810	18/38 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146017
Domainoid	1	1.000	139	1.000	Domainoid score	I4806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4925
Inparanoid	1	1.050	839	1.000	Inparanoid score	I452
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54540
OrthoDB	1	1.010	-	-		D1263405at2759
OrthoFinder	1	1.000	-	-		FOG0008427
OrthoInspector	1	1.000	-	-		oto89864
orthoMCL	1	0.900	-	-		OOG6_101111
Panther	1	1.100	-	-	LDO	PTHR46376
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	1	1.000	-	-		X3027
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940