DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lztr1 and Hcfc2

DIOPT Version :9

Sequence 1:NP_001259114.1 Gene:Lztr1 / 31037 FlyBaseID:FBgn0040344 Length:998 Species:Drosophila melanogaster
Sequence 2:XP_030101101.1 Gene:Hcfc2 / 67933 MGIID:1915183 Length:788 Species:Mus musculus


Alignment Length:338 Identity:86/338 - (25%)
Similarity:126/338 - (37%) Gaps:101/338 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 WTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPR 302
            |.|:......|...|..|..||.::.|.:|||.| :.:.::|..:......|......|..|...
Mouse     9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGN-EGIADELHVYNTVTNQWFLPAVRGDIPPGC 72

  Fly   303 YHHSAVVAGSSMFIFGG------YTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKF-------SGR 354
            ..|..|..|:.:.:|||      |:.::              |:.|::.|: ||.       ||.
Mouse    73 AAHGFVCDGTRILVFGGMVEYGRYSNEL--------------YELQASRWL-WKKVKPQPPPSGF 122

  Fly   355 QPVPRSAHGAAVYDNKMWIYAGY-----DGNAR----LNDMWTLNLTGENQWEEVDQLGDRPPTC 410
            .|.||..|..::|.||.:::.|.     |.|..    |||.:.|.|          |.|      
Mouse   123 PPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELEL----------QHG------ 171

  Fly   411 CNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHH 475
                           ||..|..|                    |..:|..   ||.|..||.:.:
Mouse   172 ---------------SGVVGWSI--------------------PATKGVV---PSPRESHTAIIY 198

  Fly   476 DR------FLYVFGGSADSTLPNDLHCYDLDSQVWSVIQPEQNSDVPSGRVFHASAVICDAMYIF 534
            .:      .:|||||...:.| :||...||::..||  :||....||..|..|.::||.:.||||
Mouse   199 CKKDSASPKMYVFGGMCGARL-DDLWQLDLETMSWS--KPETKGTVPLPRSLHTASVIGNKMYIF 260

  Fly   535 GGTVDNSVRRGDT 547
            ||.|.:.....:|
Mouse   261 GGWVPHKGENPET 273

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lztr1NP_001259114.1 PLN02153 237..554 CDD:177814 86/338 (25%)
KELCH repeat 252..298 CDD:276965 12/45 (27%)
Kelch_3 261..310 CDD:290151 11/48 (23%)
Kelch_5 299..>329 CDD:290565 8/35 (23%)
KELCH repeat 302..355 CDD:276965 14/65 (22%)
Kelch_1 358..400 CDD:279660 14/50 (28%)
KELCH repeat 359..407 CDD:276965 15/56 (27%)
KELCH repeat 410..455 CDD:276965 4/44 (9%)
Kelch_1 410..452 CDD:279660 4/41 (10%)
Kelch_1 466..509 CDD:279660 15/48 (31%)
KELCH repeat 467..509 CDD:276965 15/47 (32%)
BTB 564..704 CDD:279045
BTB 575..707 CDD:197585
SPOP_C_like 707..766 CDD:269810
BTB 798..898 CDD:279045
BTB 802..902 CDD:197585
SPOP_C_like 902..960 CDD:269810
Hcfc2XP_030101101.1 PLN02193 <2..262 CDD:177844 82/325 (25%)
KELCH repeat 23..69 CDD:276965 12/46 (26%)
KELCH repeat 127..186 CDD:276965 21/109 (19%)
PLN02193 <232..>375 CDD:177844 18/44 (41%)
KELCH repeat 245..312 CDD:276965 12/29 (41%)
FN3 <547..601 CDD:238020
FN3 607..707 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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