DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lztr1 and CG6758

DIOPT Version :9

Sequence 1:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_611647.1	Gene:	CG6758 / 37532	FlyBaseID:	FBgn0034704	Length:	667	Species:	Drosophila melanogaster

Alignment Length:	260	Identity:	70/260 - (26%)
Similarity:	112/260 - (43%)	Gaps:	29/260 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 AKRSKHTVVAYKDAMFVFGGDNGKN-MLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSS 313
            |.|..|:.|...::|:||||.:..: ..|||.||.:....|.|..||||.|:|:...|.|...:.
  Fly   101 AGRFAHSAVRQDNSMYVFGGGSSSDTTFNDLWRFDLTHMRWARPVATGTYPSPKGSASMVAWRNQ 165

  Fly   314 MFIFGGYT-GDIH-SNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAG 376
            :.:|||:. ..:| ........::|..|......|: .:.|...|.|.:.|.|.|:.::|.::.|
  Fly   166 LILFGGWRYPSLHPPYQPWCLFDELHYYDLGKNRWL-LRSSLSSPPPMAGHSATVHGDRMVVFGG 229

  Fly   377 Y----DGNARLNDMWTLNLTGENQWEEVDQLGDRP-PTCCNFPVAVARDAMYVFSGQSGLQITNS 436
            |    |.|...||.|.|:|..:..|:.:.....|| |......|.:.|:.:.:..|..|   .|.
  Fly   230 YQIKDDFNVNSNDTWVLDLPEQRWWQPLFVGNTRPSPRYGQIQVELGRNHLLIVGGCGG---ANR 291

  Fly   437 LFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHH--------DRFLYVFGGSADSTLPND 493
            ::     |..|.......|....:.|..::|:|  .||.        :.:|.|.|.|.:  :|.|
  Fly   292 VY-----TDAWLLDMTRDVWSWKSIAVRNKRFG--AVHMWCNPGCKVNNYLVVVGPSPN--MPQD 347

Fly 494 493
Fly 348 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	70/260 (27%)
		KELCH repeat	252..298	CDD:276965	18/46 (39%)
		Kelch_3	261..310	CDD:290151	20/49 (41%)
		Kelch_5	299..>329	CDD:290565	8/31 (26%)
		KELCH repeat	302..355	CDD:276965	10/54 (19%)
		Kelch_1	358..400	CDD:279660	15/45 (33%)
		KELCH repeat	359..407	CDD:276965	14/51 (27%)
		KELCH repeat	410..455	CDD:276965	7/44 (16%)
		Kelch_1	410..452	CDD:279660	7/41 (17%)
		Kelch_1	466..509	CDD:279660	10/36 (28%)
		KELCH repeat	467..509	CDD:276965	10/35 (29%)
		BTB	564..704	CDD:279045
		BTB	575..707	CDD:197585
		SPOP_C_like	707..766	CDD:269810
		BTB	798..898	CDD:279045
		BTB	802..902	CDD:197585
		SPOP_C_like	902..960	CDD:269810
CG6758	NP_611647.1	F-box-like	24..>59	CDD:289689
		KELCH repeat	103..148	CDD:276965	16/44 (36%)
		Kelch_3	112..162	CDD:290151	20/49 (41%)
		KELCH repeat	154..209	CDD:276965	10/55 (18%)
		Kelch_5	209..249	CDD:290565	14/39 (36%)
		KELCH repeat	212..257	CDD:276965	14/44 (32%)
		KELCH repeat	267..314	CDD:276965	9/54 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870