DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lztr1 and tea1

DIOPT Version :9

Sequence 1:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_588351.1	Gene:	tea1 / 2539047	PomBaseID:	SPCC1223.06	Length:	1147	Species:	Schizosaccharomyces pombe

Alignment Length:	1035	Identity:	212/1035 - (20%)
Similarity:	365/1035 - (35%)	Gaps:	280/1035 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 GGAASSSHPPGSSCSSGPGGSGCSMAYDAASNASSG---------SGSGSGKATSPGSYSCNALN 226
            |.|...:.|..|..|:.|..|....::::....|:.         :||||....||
pombe    10 GSAHKPTKPNFSKTSTTPSTSQLKHSHESNVKMSTSTVTEHRKKPTGSGSHITASP--------- 65

  Fly   227 VDFTSYTATHQWTRMLECAEFVGAKRSKHTVVAYKDA---MFVFGG-DNGKNMLNDLIRFGVKDK 287
                       |:::..........|..|....|.:.   :::||| .:.....|||....:...
pombe    66 -----------WSKLTVRGSSNVLPRYSHASHLYAEGGQEIYIFGGVASDSQPKNDLWVLNLATS 119

  Fly   288 SWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNK--NDLFEYKFQSAMWVEWK 350
            .:....:.|..|:||..|::::.|::..:|||.|     |.::.::  |.|:.....|.:|.:..
pombe   120 QFTSLRSLGETPSPRLGHASILIGNAFIVFGGLT-----NHDVADRQDNSLYLLNTSSLVWQKAN 179

  Fly   351 FSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNL----TGENQWEEVDQLGDRPPTCC 411
            .||.:|..|..|..:...:|:.::.|...:...||:...:|    |.:::||....:.|.||...
pombe   180 ASGARPSGRYGHTISCLGSKICLFGGRLLDYYFNDLVCFDLNNLNTSDSRWELASVVNDPPPARA 244

  Fly   412 NFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHD 476
            ........|.:|:|.|..|....|.|:.:|.|...|.::....|       .|:.|.||.....:
pombe   245 GHVAFTFSDKLYIFGGTDGANFFNDLWCYHPKQSAWSKVETFGV-------APNPRAGHAASVVE 302

  Fly   477 RFLYVFGGSA-DSTLPNDLHCYDLDSQVWSVIQPEQNSDV---PSGRVFHASAVICDAMYIFG-- 535
            ..||||||.| |.|..|||:.:.|.|:.|..:     ||:   ||.|..|..:.....:.:.|
pombe   303 GILYVFGGRASDGTFLNDLYAFRLSSKHWYKL-----SDLPFTPSPRSSHTLSCSGLTLVLIGGK 362

  Fly   536 ---GTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQDKQFCDIQFIVG---------------- 581
               |..|::|...||.||:..|.|..:.|.....||.:.        .|
pombe   363 QGKGASDSNVYMLDTSRFRLGSVPTTSGRQRNTSFFSNS--------TGNTNPSAFNGLLTSSRI 419

  Fly   582 ----AEEIRILAHIAFVAARSKY--------------------------LRNKILAAREARQQQM 616
                ..::|..:|    .:|.:|                          |.:.::..|......:
pombe   420 PSYNGSKVRSTSH----PSRQQYIGSSNSRFNTRHQTISTPVSGRASNDLPSPVVPTRSNSSSIL 480

  Fly   617 EKVYGV----------GQVDALALN-------AGAGGDRGPMLE---------------VRLANA 649
            :..|.:          ...|..:||       |.|.|:..|.|.               ....||
pombe   481 QPSYNLNSHSSDRRNTNDDDQSSLNSQQLSNQAKAQGEVSPTLSFVPSSHSMEQGNGSVASANNA 545

  Fly   650 SPEAFEIILNYI-------YTDRIDLKDT-YSKNIIILITDI--------------YQLAGLF-- 690
            ..||....:|.|       :.::..:|.. ..|::...||.:              .|:...|
pombe   546 QSEAATRSINSISEVSEVRFPEQSSVKTVDERKSLDGRITSVTLETLVEKYSELSKQQIVEWFKS 610

  Fly   691 TMPRLAHGCIQYLDYKINKLNVLEALYNA--------------------------DKSNIKIIKD 729
            .:..:.......:|....||.|..|..||                          ||.|::...|
pombe   611 KLYEILRDSASKIDSLTEKLKVANAEKNAALCEAALEKVPLAKHNKLSDGTFSTPDKENVQSTND 675

  Fly   730 -HCMQFIIKEENFT----DVVMSSEFSDLDKPLLVE-------IIRKRLYPSKLVIDTSYEGNIG 782
             |.||     |||:    ..||....|||||.|...       |::...:..:||.:......|.
pombe   676 AHIMQ-----ENFSLHKALEVMRETSSDLDKQLKDATASQKELIVQTSSFQKELVEERERHNAIS 735

  Fly   783 TTLEIDLCAFLESTGKDFCDISLVLEDHVIPAHKSVLSSRCTYFQGMFRS-FMPPDNTVNIQIGE 846
            ..|:     .:||..:|...:...|||.::  .::|..::..:.:..||. .|..:||:.    :
pombe   736 KRLQ-----EIESLYRDRELLVTNLEDQLV--DQTVTINKFAFERDQFRERSMGFENTIK----D 789

  Fly   847 ISPSLEA-------FHSLLRYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNITF 904
            ::..:||       .|..||.:....:::..:.||...:......:.:...:.:.|.:.:|. .:
pombe   790 LTRKMEATDMLNVSLHESLRSVQTENSELVTEMALLKAELVKKQAIIDANANIYDKLTADHT-NY 853

  Fly   905 ENVLQTLEASDITKIYDIKEYALKLI--VKDF----------------AKVARLPKIAGLSR--- 948
            |.|     ::||.:  ::||...||:  ..||                ||:.:..|:...|:
pombe   854 ETV-----SADINQ--NLKETLDKLLNGSSDFKNNEIELLHDQIRITNAKLEKREKLINASKYIE 911

  Fly   949 ELLLEIIRAVAD--SHGEF----LTRININTDIXKLVLLQP----ALQLLLAWLQIGRST 998
            :.|...|:..|:  |:.||    |...|.|..: .:..|:.    |.||:...:|:..:|
pombe   912 DTLRSEIQEAAEKVSNLEFSNFNLKEENSNMQLQLMKALEQRNTGAKQLVNLRMQLSTAT 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	85/335 (25%)
		KELCH repeat	252..298	CDD:276965	10/49 (20%)
		Kelch_3	261..310	CDD:290151	11/52 (21%)
		Kelch_5	299..>329	CDD:290565	10/29 (34%)
		KELCH repeat	302..355	CDD:276965	14/54 (26%)
		Kelch_1	358..400	CDD:279660	10/45 (22%)
		KELCH repeat	359..407	CDD:276965	11/51 (22%)
		KELCH repeat	410..455	CDD:276965	10/44 (23%)
		Kelch_1	410..452	CDD:279660	10/41 (24%)
		Kelch_1	466..509	CDD:279660	18/43 (42%)
		KELCH repeat	467..509	CDD:276965	18/42 (43%)
		BTB	564..704	CDD:279045	30/241 (12%)
		BTB	575..707	CDD:197585	29/233 (12%)
		SPOP_C_like	707..766	CDD:269810	25/96 (26%)
		BTB	798..898	CDD:279045	18/107 (17%)
		BTB	802..902	CDD:197585	18/107 (17%)
		SPOP_C_like	902..960	CDD:269810	16/78 (21%)
tea1	NP_588351.1	KELCH repeat	80..131	CDD:276965	10/50 (20%)
		Kelch_3	92..142	CDD:290151	11/49 (22%)
		KELCH repeat	134..181	CDD:276965	12/51 (24%)
		Kelch_3	143..194	CDD:290151	15/55 (27%)
		Kelch_2	187..236	CDD:284956	10/48 (21%)
		KELCH repeat	188..239	CDD:276965	10/50 (20%)
		Kelch_1	242..287	CDD:279660	10/44 (23%)
		KELCH repeat	243..290	CDD:276965	11/53 (21%)
		Kelch_4	292..338	CDD:290154	20/50 (40%)
		KELCH repeat	293..338	CDD:276965	20/49 (41%)
		SbcC	594..>1121	CDD:223496	82/402 (20%)
		ATP-synt_B	<608..726	CDD:304375	28/122 (23%)
		RILP-like	<866..952	CDD:304877	19/85 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940