DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lztr1 and KLHDC10

DIOPT Version :10

Sequence 1:NP_001259114.1 Gene:Lztr1 / 31037 FlyBaseID:FBgn0040344 Length:998 Species:Drosophila melanogaster
Sequence 2:NP_055812.1 Gene:KLHDC10 / 23008 HGNCID:22194 Length:442 Species:Homo sapiens


Alignment Length:436 Identity:90/436 - (20%)
Similarity:152/436 - (34%) Gaps:121/436 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 MSMSSSMRSSRGNGGGGAASSSHPPGSSCSSGPGGSGCSMAYDAASNASSGSGSGSGKATSPGSY 220
            ||.:.....:|..|||.|             |.||.|            ||:|.|||     || 
Human     1 MSAAQGWDRNRRRGGGAA-------------GAGGGG------------SGAGGGSG-----GS- 34

  Fly   221 SCNALNVDFTSYTATHQWTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRF--- 282
                                                            |..|...||..::.   
Human    35 ------------------------------------------------GGRGTGQLNRFVQLSGR 51

  Fly   283 ----GVKDKSW-----------------GRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHS 326
                |.|...|                 .|......||..|..|..|...:::::||||..|...
Human    52 PHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDE 116

  Fly   327 NSNLTNKN-----DLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYD---GNARL 383
            :....|::     :|:.|.|.:.:|.:....|..|...::....::.|.:.::.|..   |.:..
Human   117 SGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNG 181

  Fly   384 NDMWTLNLTGENQWEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWR 448
            ||:...|:. ..:|..:...|.:|.......:|:...::|||.|.:|...:..|.:....||.|.
Human   182 NDVHVCNVK-YKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWT 245

  Fly   449 RISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTL--PNDLHCYDLDSQVWSVI--QP 509
            ::  :|  ...:...|..||.|.:.|..:.:|:.||....|.  .|.:|.|:|::..|..|  :|
Human   246 QL--KP--NNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKP 306

  Fly   510 EQNSDVPSGRVFHASAVICDAMYIFGGTVDNSVRRGDTYRFQFSSY 555
            .:....|:.|..|:...|.:.::|.|| .:..|..||.::....::
Human   307 HEKIGFPAARRCHSCVQIKNDVFICGG-YNGEVILGDIWKLNLQTF 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lztr1NP_001259114.1 NanM 252..551 CDD:442289 71/334 (21%)
KELCH repeat 252..298 CDD:276965 8/69 (12%)
KELCH repeat 302..355 CDD:276965 14/57 (25%)
KELCH repeat 359..407 CDD:276965 8/50 (16%)
KELCH repeat 410..455 CDD:276965 10/44 (23%)
KELCH repeat 467..509 CDD:276965 14/45 (31%)
BTB1_POZ_LZTR1 551..704 CDD:349617 0/5 (0%)
BACK1_LZTR1 708..766 CDD:350580
BTB2_POZ_LZTR1 781..906 CDD:349618
BACK2_LZTR1 902..962 CDD:350581
KLHDC10NP_055812.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 23/134 (17%)
Kelch 1. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 87..154 17/66 (26%)
NanM 89..401 CDD:442289 62/269 (23%)
KELCH repeat 92..150 CDD:276965 14/57 (25%)
KELCH repeat 154..204 CDD:276965 8/50 (16%)
Kelch 2. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 155..198 7/43 (16%)
Kelch 3. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 199..260 14/64 (22%)
KELCH repeat 208..256 CDD:276965 11/51 (22%)
KELCH repeat 260..313 CDD:276965 15/52 (29%)
Kelch 4. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 261..319 16/57 (28%)
KELCH repeat 316..362 CDD:276965 9/37 (24%)
Kelch 5. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 320..364 7/33 (21%)
Kelch 6. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 365..403
Interaction with CUL2. /evidence=ECO:0000269|PubMed:23102700 401..442
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.