DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lztr1 and lztr1

DIOPT Version :9

Sequence 1:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_001121508.1	Gene:	lztr1 / 100158621	XenbaseID:	XB-GENE-998506	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	754	Identity:	419/754 - (55%)
Similarity:	552/754 - (73%)	Gaps:	14/754 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 YSCN----ALNVDFTSYTATHQWTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLI 280
            :||:    .|.::|..:.:.|:|.|:|.|.|||||:||||||||||||::||||||||||||||:
Frog    15 HSCSDSVEYLTLNFGPFESVHRWRRLLPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKNMLNDLL 79

  Fly   281 RFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQSAM 345
            ||.|||.||.||..||:||||||||||||.|||||:||||||||:|||||.||||||||||.:.:
Frog    80 RFDVKDCSWCRAFTTGSPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGL 144

  Fly   346 WVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTGENQ--WEEVDQLGDRPP 408
            |.|||..||.||.||||||.||.:|:||:||||||||||||||:.|...:.  |||::|.|:.||
Frog   145 WTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRDLTCWEEIEQSGEIPP 209

  Fly   409 TCCNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMV 473
            :||||||||.||.|:|||||||.:|||:||:|.|..:.|.||..|.:||| :..||.||||||||
Frog   210 SCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFSEKVWTRIPTEHLLRG-SPPPPQRRYGHTMV 273

  Fly   474 HHDRFLYVFGGSADSTLPNDLHCYDLDSQVWSVIQPEQNSDVPSGRVFHASAVICDAMYIFGGTV 538
            ..||.||||||:||:||||:|||||:|||.|.|||...:|::||||:|||:|||.||||||||||
Frog   274 AFDRHLYVFGGAADNTLPNELHCYDVDSQSWEVIQASPDSELPSGRLFHAAAVIADAMYIFGGTV 338

  Fly   539 DNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQDKQFCDIQFIVGAEEIRILAHIAFVAARSKYLRN 603
            ||:||.|:.||||||.||||||.:|:|:.|:::||||::||:|.:|.|:..|.|.|.||.|:||.
Frog   339 DNNVRSGEMYRFQFSCYPKCTLHEDYGRLFENQQFCDVEFILGEKEERVRGHTAIVTARCKWLRK 403

  Fly   604 KILAAREARQQQM-----EKVYGVGQVDALALNAGAGGDRGPMLEVRLANASPEAFEIILNYIYT 663
            ||:.|||.::|::     :::....|....|.:........|||||.:.:|....||:::.::||
Frog   404 KIMQARERQKQKLKQEPEDEMQNSQQKTESACSQVKLSRSQPMLEVIIRDAEARPFELLMQFLYT 468

  Fly   664 DRIDLKDTYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKLNVLEALYNADKSNIKIIK 728
            |:|..........::||.|:|:||..|.:.||...|:||::..::..|||....||:|..:..:|
Frog   469 DKIKYPRKGHVEDVLLIMDVYKLALHFKLSRLEQLCVQYIEASVDLQNVLGVCENANKLQLDELK 533

  Fly   729 DHCMQFIIKEENFTDVVMSSEFSDLDKPLLVEIIRKRLYPSKLVIDTSYEGNIGTTLEIDLCAFL 793
            :||:.|::||.:|..|:|..||..|...|:|||:|::..| .|.|.:....:|||:|..|:.|:|
Frog   534 EHCLNFVVKESHFNQVIMMKEFEHLSSSLIVEIVRRKQQP-PLRIHSDQPVDIGTSLVQDMKAYL 597

  Fly   794 ESTGKDFCDISLVLEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDNTVNIQIGEISPSLEAFHSLL 858
            |..|.|||||:|:|:.|..|||:::|::|.:||:.|||||||.|..|||.|||:.||.:||.|||
Frog   598 EGAGNDFCDITLLLDGHPRPAHQAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSKQAFESLL 662

  Fly   859 RYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNITFENVLQTLEASDITKIYDIK 923
            |||||||..|||:|:||||.||.:||..:|||.|:|:.:||.|:|.|||||.|||:|.|:..|:|
Frog   663 RYIYYGEVNMPPEDSLYLFSAPYYYGFFSNRLQAYCRQNLEMNVTVENVLQILEAADKTQAVDMK 727

  Fly   924 EYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSH 962
            ::.|.:||..|.|||:||.:..||:.||:.||.::| ||
Frog   728 KHCLHIIVHQFTKVAKLPNLRLLSQPLLINIIESLA-SH 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	226/318 (71%)
		KELCH repeat	252..298	CDD:276965	37/45 (82%)
		Kelch_3	261..310	CDD:290151	39/48 (81%)
		Kelch_5	299..>329	CDD:290565	26/29 (90%)
		KELCH repeat	302..355	CDD:276965	41/52 (79%)
		Kelch_1	358..400	CDD:279660	28/43 (65%)
		KELCH repeat	359..407	CDD:276965	31/49 (63%)
		KELCH repeat	410..455	CDD:276965	29/44 (66%)
		Kelch_1	410..452	CDD:279660	28/41 (68%)
		Kelch_1	466..509	CDD:279660	33/42 (79%)
		KELCH repeat	467..509	CDD:276965	32/41 (78%)
		BTB	564..704	CDD:279045	51/144 (35%)
		BTB	575..707	CDD:197585	46/136 (34%)
		SPOP_C_like	707..766	CDD:269810	23/58 (40%)
		BTB	798..898	CDD:279045	60/99 (61%)
		BTB	802..902	CDD:197585	59/99 (60%)
		SPOP_C_like	902..960	CDD:269810	28/57 (49%)
lztr1	NP_001121508.1	PLN02153	51..348	CDD:177814	212/297 (71%)
		KELCH repeat	51..97	CDD:276965	37/45 (82%)
		KELCH repeat	101..155	CDD:276965	42/53 (79%)
		KELCH repeat	267..311	CDD:276965	33/43 (77%)
		BTB1_POZ_LZTR1	351..509	CDD:349617	61/157 (39%)
		BACK1_LZTR1	513..571	CDD:350580	23/57 (40%)
		BTB2_POZ_LZTR1	585..710	CDD:349618	73/124 (59%)
		BACK2_LZTR1	706..766	CDD:350581	31/61 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4925
Inparanoid	1	1.050	853	1.000	Inparanoid score	I429
OMA	1	1.010	-	-		QHG54540
OrthoDB	1	1.010	-	-		D1263405at2759
OrthoFinder	1	1.000	-	-		FOG0008427
OrthoInspector	1	1.000	-	-		oto103675
Panther	1	1.100	-	-	LDO	PTHR46376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3027
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080