DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11664 and HGF

DIOPT Version :9

Sequence 1:	NP_569865.1	Gene:	CG11664 / 31033	FlyBaseID:	FBgn0040341	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	245	Identity:	61/245 - (24%)
Similarity:	100/245 - (40%)	Gaps:	47/245 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GIPVQQQNYGYVMQI-YGPQFLAAGSLFSARYVLTVAHCF-KKNTKPEELSVRAGYRWIAW---- 84
            |||. :.|.|:::.: |..:.:..|||....:|||...|| .::.|..|          ||
Human   498 GIPT-RTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYE----------AWLGIH 551

  Fly    85 EFRGK---------QVAGLLRHPKFSPLTLRNDIAVLRVKAAISHSHMINYIGLCSRP-LTPLNM 139
            :..|:         .|:.|:..|:.|.|.|........:...:|...:.|| | |:.| .|..::
Human   552 DVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNY-G-CTIPEKTSCSV 614

  Fly   140 FAPPQELAGW---NLMHIAQPLKSMSVQVEPEKNCRQWF---PQISGGVICASA-TMGEGLCYGD 197
            :       ||   .|::....|:...:.:...:.|.|..   ..::...|||.| .:|.|.|.||
Human   615 Y-------GWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGD 672

  Fly   198 SGDPLISGGE----VCGLAIAFRKCGDKRYPALFTDVHYHRAFIAQAVLT 243
            .|.||:....    |.|:.:..|.|.....|.:|..|.|:..:|.:.:||
Human   673 YGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILT 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11664	NP_569865.1	Tryp_SPc	38..239	CDD:304450	54/227 (24%)
CG11664	NP_569865.1	Tryp_SPc	38..237	CDD:214473	53/225 (24%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	58/237 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930