DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43867 and PLEKHH1

DIOPT Version :9

Sequence 1:NP_001284762.1 Gene:CG43867 / 31031 FlyBaseID:FBgn0264449 Length:1852 Species:Drosophila melanogaster
Sequence 2:XP_011535311.1 Gene:PLEKHH1 / 57475 HGNCID:17733 Length:1392 Species:Homo sapiens


Alignment Length:1630 Identity:567/1630 - (34%)
Similarity:799/1630 - (49%) Gaps:416/1630 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   271 QALPQINWQERCLELQLELHRSKNQAGRIRDMLREKLTELEQRVIEAEERAEEAEDKVRAMEQ-- 333
            :|...::||:|||.|:.:|.|.:.||.:||::|.:|:.|||||::|||:|||.||.:|..||:  
Human     7 EAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKV 71

  Fly   334 RLSEWPKPPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETE 398
            :||.......:.:.|     ..:|.:                               |...:..:
Human    72 KLSNLKNVDSEGSLH-----RKYQEL-------------------------------LKAIKGKD 100

  Fly   399 KTITSLEIQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKN 463
            :.|:.||.|:|:|:|:|..:|:.::.|||||||||..||..||.:||.|:..|.:..:|:..|::
Human   101 ELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQD 165

  Fly   464 HI-------------------------------------ANQSQ--RHSIVGP------VRNSLS 483
            .:                                     .:|:|  :.:::.|      .::|:|
Human   166 ALEAIQIAPSRKLLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVS 230

  Fly   484 LDVQDFTGSGSNPEHRRRSESLDP-QEIIGRPLTSSYPHHQHRRNLSMEPQELE--RNLVAAVDG 545
            ........|.|:..|...:....| |..:||   .|.||....:.|:.......  ..||.|..|
Human   231 EAASPLEDSSSSTVHSGETVEAKPLQPHLGR---ESPPHQPCMKLLTFRCSSASWGEGLVTAQRG 292

  Fly   546 LTLAPLSSISNKAPG-----------GVPTESGVVTRPDSSDTDTAHDY--------AEIYT--- 588
            :.....:|.....||           |.|.:|..:.:...|.....|.:        .|.::   
Human   293 MLPGTKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALH 357

  Fly   589 PSCEKLP-----AWMKNNPALM------ASGGNSSTTTTTT-------SELGVPRPPTPPLHRFP 635
            ||  .||     |..:..|..|      .:|.|....:...       .||| .:|||||||:|.
Human   358 PS--GLPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELG-NKPPTPPLHQFS 419

  Fly   636 SWEAKIYQVANDG--LAGAGTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDG 698
            |||::||.||..|  |:.....::|| ..||..|.:                       :..|..
Human   420 SWESRIYAVATSGMRLSDMSPRSNTA-CCASSPPAL-----------------------VSPGSF 460

  Fly   699 HGTLGSTPGTPLPPSRQQQTASGGFCDISVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHAVM 763
            .|.:                    :.:::||||..:||||:||.:|||.     |.|.|.|    
Human   461 SGLV--------------------YKNVTVPVYTALKGRATQISNMPFM-----DESSGSD---- 496

  Fly   764 LTHHSHNSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTPSS 828
                       |:..:..|...|.||...:        |.||..||:..|               
Human   497 -----------DDCSSQASFRISVPSSESR--------KTSGLGSPRAIK--------------- 527

  Fly   829 RINQHLQPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTVIS 893
                                                                       ||..:|
Human   528 -----------------------------------------------------------RGVSMS 533

  Fly   894 DLSFESGLSDDYALPPDAVSESTCMDASMP--SLLMRQSY-VDSPSKKIESLEKMGHLAKLGGKL 955
            .||.|.    |||:||||.|..:  |.|.|  .|....|| .|......|||||.|:|.|:|.::
Human   534 SLSSEG----DYAIPPDACSLDS--DYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQV 592

  Fly   956 KTWRKRWFVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSH 1020
            |||::|||||:.|.:.|:||..||.||||||:.|:..|:|.|.||:.||::.:.||.|||||||.
Human   593 KTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSP 657

  Fly  1021 ATMDDWIRVLQNVQRRNAT-KLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAE 1084
            :.:::||||||::.:..|| ...|.|...||||:||:||||:||.|..||.|:||:|.|:::..:
Human   658 SLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHED 722

  Fly  1085 ----------------------------TNPLGQINMRDARVEEVEHVSDSDSEEREDAAQD--Q 1119
                                        ..|||.:.:|||.:|||:...|||.:......:.  .
Human   723 KLHGAYVFRERRLPHPPLALPFMEDCCPQRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLS 787

  Fly  1120 ARLTVAIYPAHQGPTYLILSGKPERDNWLYHLTVVSGGGPS-AGTQYEQLVQKLMETDGDPNCVL 1183
            :..|:.|:|....||||::..|.|:|.|||||||.:||..: .||.||||:.|||:.:|||:..|
Human   788 SHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPL 852

  Fly  1184 WRHPILLHTKDTITAPLSSMHTETMQPEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALD 1248
            ||||:|.::||.:.|.|:::.:|.:|.||:|||||.|||::|.|....:||||.|||.|||..|.
Human   853 WRHPMLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLV 917

  Fly  1249 MPELQTEMICILIKQTSRHLGQKLSVGVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGS 1313
            .||||:|:.|.|:||||                                                
Human   918 HPELQSEIYCQLMKQTS------------------------------------------------ 934

  Fly  1314 SPTSIQAPSATPIIDCKSNPPVYSFVQGWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETG 1378
                           |:. |..||.:|.||||||...||:|: ...|||:|..|.|:||.::|||
Human   935 ---------------CRP-PQKYSLMQCWQLLALCAPLFLPQ-HHFLWYVKQQLQRHADPRSETG 982

  Fly  1379 KYAAYCERALERTLKNGGRETKPSRMEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTI 1443
            :||.||:||:||||:.|.||.:||||||:||||:||:|||||.:||||..|.||.||.||||:|:
Human   983 QYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTV 1047

  Fly  1444 EEFQATLAHELGTRDAT-NGFCLFSDDPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFE-N 1506
            :||...|..|:|.|..: :||.||:|||..:||||.|:...|:||.|||||.|::|...||.| .
Human  1048 DEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEGG 1112

  Fly  1507 SRVIQLSYKNRLYWKHTIKCETDKERLLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGDYS 1571
            :||::|.||||||::..:|.|||:|||||..||:.:||.||||:::|||||:|:||:|::.||  
Human  1113 TRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALMAQVEYGD-- 1175

  Fly  1572 LEKSRDVGVG-----------LKGLDKFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCV 1625
            |||....|.|           .:.||:|:|.|||....||||:.:.::|.:||..|:|.|..:|:
Human  1176 LEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECI 1240

  Fly  1626 RIYLTCCRKWPYFGACLFQAKPRQSPESNTASGATPVAWLAVAEDALNVLELSTMAPVARYPYSS 1690
            |||||..||||:|||.||.|:|.|......|     :.|:||.||.:::|:.:||.....|||||
Human  1241 RIYLTVARKWPFFGAKLFAAQPAQLSSKENA-----LVWIAVNEDGVSILDHNTMQVHITYPYSS 1300

  Fly  1691 VMTFGGCQDDFMLVV-SHDDGGGGE---QKLLFAMSKPKILEITLLIADYMNALGHTV------P 1745
            |.|||||:||||||: |..|...|:   :||:|.|:.|||.|.|.::|.|||....||      |
Human  1301 VTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMASYMNHCTTTVNPPTNPP 1365

  Fly  1746 GTPQM 1750
            |..|:
Human  1366 GACQL 1370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43867NP_001284762.1 PH 942..1035 CDD:278594 50/92 (54%)
PH1_PLEKHH1_PLEKHH2 944..1039 CDD:241436 48/94 (51%)
PH 1050..1151 CDD:214574 44/130 (34%)
PH 1053..1151 CDD:278594 41/127 (32%)
MyTH4 1191..1410 CDD:214535 85/218 (39%)
B41 1423..1643 CDD:214604 117/232 (50%)
FERM_M 1527..1643 CDD:278785 62/126 (49%)
PH-like 1639..1741 CDD:302622 49/105 (47%)
PLEKHH1XP_011535311.1 flagell_FliJ 27..164 CDD:131526 55/172 (32%)
FlgN 31..186 CDD:298847 55/190 (29%)
PH 579..672 CDD:278594 50/92 (54%)
PH1_PLEKHH1_PLEKHH2 581..676 CDD:241436 48/94 (51%)
MyTH4 860..1014 CDD:214535 85/218 (39%)
B41 1027..1258 CDD:214604 117/232 (50%)
FERM_M 1130..1258 CDD:278785 63/129 (49%)
FERM_C-lobe_PLEKHH1_PLEKHH2 1254..1356 CDD:241360 49/106 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 141 1.000 Domainoid score I4715
eggNOG 1 0.900 - - E1_KOG0248
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H121939
Inparanoid 1 1.050 871 1.000 Inparanoid score I419
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48143at33208
OrthoFinder 1 1.000 - - FOG0004352
OrthoInspector 1 1.000 - - otm40422
orthoMCL 1 0.900 - - OOG6_106231
Panther 1 1.100 - - LDO PTHR22903
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3701
SonicParanoid 1 1.000 - - X3070
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.860

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