Protein Alignment CG43867 and plekhh2

DIOPT Version :9

• Sequence 1: NP_001284762.1
• Gene: CG43867 / 31031
• FlyBaseID: FBgn0264449
• Length: 1852
• Species: Drosophila melanogaster
• Sequence 2: XP_001921439.4
• Gene: plekhh2 / 568304
• ZFINID: ZDB-GENE-081028-42
• Length: 1423
• Species: Danio rerio
• Alignment Length: 1663
• Identity: 527/1663 - (31%)
• Similarity: 772/1663 - (46%)
• Gaps: 435/1663 - (26%)

  Fly   278 WQERCLELQLELHRSKNQAGRIRDMLREKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPKPP 342
            |:|:.:.|:..|.:.:.|...:|::..||:.:||.:|:|||:||.||..:|:.||:||..
Zfish    12 WKEKYMALEALLFKFRGQMSMVRELTTEKMQQLEAQVLEAEQRAYEANQQVQWMEERLKA----- 71

  Fly   343 PQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLEIQ 407
                          ..|.|...:.:....|......               .||.::.|.:||.|
Zfish    72 --------------SDIQSSDSDVRLFRRCQNLQSV---------------LQEKDELIATLEKQ 107

  Fly   408 VEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKNHIANQSQ-- 470
            :|||:|.|:.|||.:|.|||||||||..||...|.:|..||:::.:...::::|:..:....|
Zfish   108 LEEQKQNRIQDARTVEEKAAKIKEWVMRKLNAFETENTSLRDRHQQLEAEIQVLRRQLQAMDQCS 172

  Fly   471 ---RHSIVG---------------------------PVRNSLSLDVQDFTGSGSNPEHRR----- 500
               ...|||                           |.:.|:|...:|......:||.:|
Zfish   173 DGTLQPIVGEPKRLSSLTFGCFQIRGKSPQVQTGPEPSQRSISTLQEDSGDKQESPETQRISRCS 237

  Fly   501 --RSESLDPQEIIGRPL---------------------------TSSYPHHQHRRNLSM----EP 532
              |||:...||..|..|                           |:|..:|....:.|.    :.
Zfish   238 KERSENEGEQESTGHKLSCGASSVLSSTASEGERSLFEGFCFSHTTSEAYHTTSDDSSSLFDDDM 302

  Fly   533 QELERNLVAAVD-GLTLAPLSSI---------------------SNKAPGGVPTESGVVT----- 570
            |.||.:.::..| ..||...:.:                     |:.:.....|.|.::|
Zfish   303 QRLECSRLSISDTKSTLKKGNKVEDTEDGSSDELNKHFQSQYLDSSSSSSDTNTRSPILTPVLTP 367

  Fly   571 -RP----DSSDTDTAHDYAEIYTPSCEKL------------PAWMK------------------- 599
             ||    ||.||..:.....:..|:..::            |.:.|
Zfish   368 KRPTPSQDSQDTPASPKQPRLRNPNAFEVSLALLKKHMSQPPVYSKAAHGRTRNAISMLRSLEPQ 432

  Fly   600 ----NNPALMASGGNSST--------TTTTTSELGVPRPPTPPLHRFPSWEAKIYQVANDGLAGA 652
                |....|.:|....:        |..|::.:...:||||||||.||||::||.||..|:.
Zfish   433 ETDMNEDQKMETGEKEHSDVLPEEPQTPNTSAAIPGSKPPTPPLHRLPSWESRIYAVAKSGIR-- 495

  Fly   653 GTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDGHGTLGSTPGTPLPPSRQQQ 717
                            :.:...|::.|                 ..|....|.|...|
Zfish   496 ----------------LSEISCTDVVN-----------------KDHCNASSCPSYML------- 520

  Fly   718 TASGGFCDISVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHAVMLTHHSHNSSSTDNTETSTS 782
            ..|..:.:.|.||:.|.||..:.:                             |:||.:.|:|:|
Zfish   521 YTSFIYSNNSTPVFTTHKGNVTLL-----------------------------SNSTCSEESSSS 556

  Fly   783 GSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTPSSRINQHLQPSQHQHHTLSNQ 847
            ....|..:....|.....|:.|||||                              |:.|..|:
Zfish   557 EEEESSEEFQSNSGEDEKAQTSGSES------------------------------HKSHRSSH- 590

  Fly   848 NHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTVISDLSFESGLSDDYALPPDAV 912
                                                 ...|...:|.::.||    |||:||||.
Zfish   591 -------------------------------------SFKRAVSLSSMTSES----DYAIPPDAY 614

  Fly   913 SEST-CMDASMPSLLMRQSYVDSPSKKI--ESLEKMGHLAKLGGKLKTWRK----RWFVLKNGSL 970
            |..| |.:..     .:|....|.|..|  ||:||.|:|.|:   :|||:|    .|||||:|.|
Zfish   615 STDTECFEPE-----SKQPKTCSSSGNILNESMEKSGYLLKM---VKTWKKAWKRHWFVLKDGEL 671

  Fly   971 NYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSHATMDDWIRVLQNVQR 1035
            .::||..||.|||.|||:|:....|.|.:.....::.|||.|.||.|||...:::|:||||:|||
Zfish   672 LFYKSPSDVIRKPLGQIELNACSTITRGDEKQMLQVVTGKSVCYLKADSPNLLEEWVRVLQSVQR 736

  Fly  1036 RNATKLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAETNPLGQINMRDARVEE 1100
            ..|...:.::.|.:|.::|.:|.||:|..|..||.|.||...:|:...:..|||||.|.:|||||
Zfish   737 IKAASPVFTQLDMRPVIKGHLTMVKHGCSKHVWCALFGKTLYFFRNQEDKFPLGQIKMWEARVEE 801

  Fly  1101 VEHVSDSDSEEREDAAQDQARLTVAIYPAHQGPTYLILSGKPERDNWLYHLTVVSGGG-PSAGTQ 1164
             ||.|.       |.|:..|:.|:::....||.|||::....|:..|:|||:|.:|.. ...||:
Zfish   802 -EHKSC-------DLAELSAQHTISVQSGRQGSTYLLIDSPHEKMAWVYHLSVAAGTAVGQVGTE 858

  Fly  1165 YEQLVQKLMETDGDPNCVLWRHPILLHTKDTITAPLSSMHTETMQPEAIKLFKSIQLFMSVAVNQ 1229
            :||||.||:..||:....|||||.|..:|:.:..||:::.::.:|.|||||||:.|||::||::.
Zfish   859 FEQLVGKLLNMDGNQGSQLWRHPTLCFSKEGLLFPLTTLPSQALQTEAIKLFKTCQLFINVAIDT 923

  Fly  1230 PGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQKLSVGVQVNKKLGKQTRQLLLCAT 1294
            ..|||||.|||.|||..|..||||.|:.|.|||||.:                 |||
Zfish   924 SAIDYHVTLAQCALQVCLTHPELQNEIYCQLIKQTWK-----------------KQT-------- 963

  Fly  1295 QSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPVYSFVQGWQLLALAVSLFVPRSSRL 1359
                            ||                    ||  ..:||||.|||.|.||:| :..:
Zfish   964 ----------------NG--------------------PP--GPLQGWQFLALCVGLFLP-THPI 989

  Fly  1360 LWYLKLHLSRNADTKTETGKYAAYCERALERTLKNGGRETKPSRMEVLSILLKNPYHHSLPHAIP 1424
            ||||::||.|:.|::||.||||.||:|:||||.:.|.|:.:.||||:|||||:||||||||.::|
Zfish   990 LWYLQVHLKRHGDSRTEVGKYAIYCQRSLERTQQKGERQARSSRMEILSILLRNPYHHSLPFSMP 1054

  Fly  1425 VHMMNSTYQVVSFDGSTTIEEFQATLAHELGTR-DATNGFCLFSDDPIEKDLEHYLEPLAKLCDV 1488
            ||.:|:||||||||.|||:||||:.|..::|.| ...:||..:||||..|||||.|:...|:|||
Zfish  1055 VHFLNNTYQVVSFDASTTVEEFQSRLNQDMGMRKTGQSGFSFYSDDPTGKDLEHCLQGNLKICDV 1119

  Fly  1489 ISKWETALREKGSGKFENSRVIQLSYKNRLYWKHTIKCETDKERLLLCYQTNSQIVQGRFPLSRE 1553
            |:|||.|.:|:..||.|.:|.::|:||||||:...:..||::|||||.||||.:|..|.||:::|
Zfish  1120 IAKWEQASKEQHRGKAEIARTVKLTYKNRLYFSKQVSGETERERLLLAYQTNEEITAGHFPVNKE 1184

  Fly  1554 LALELASLMSQIDMGDYSLEKSRDVGVG----------LKGLDKFYPYRYRDALGAEQLKDVQEL 1608
            ||||:|:|::|::.||:....|...|.|          .:.|::|||..|:.....|:.:.:.:.
Zfish  1185 LALEMAALLAQVEFGDFEHPLSSPGGSGNTPTKSNQTLRQVLERFYPKHYQHTCTEEENRQLIQR 1249

  Fly  1609 LVSKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQSPESNTASGATPV-AWLAVAEDAL 1672
            |.::|..|:|:::.:|:|||||..|||.:|||.||:|      |:.|.|....| .||||.||.:
Zfish  1250 LSTRWASLRGQTSSECIRIYLTVARKWSFFGAKLFEA------ETVTPSALKNVRVWLAVHEDGI 1308

  Fly  1673 NVLELSTMAPVARYPYSSVMTFGGCQDDFMLVVSHDDGGG-GEQKLLFAMSKPKILEITLLIADY 1736
            :|||.:.:..:|.|||.|::|||.|.:||.|||:...|.| .:.|.||||:..|:.::.||||.|
Zfish  1309 SVLEFNAIKVLASYPYKSIVTFGVCGEDFKLVVAESSGSGTSKGKHLFAMTSSKVRDLVLLIASY 1373

  Fly  1737 MN------ALGHTVPGTPQMNSLTRNGSHRSLRTSQRP 1768
            :.      |..|.:.....:.:|:....:...|:...|
Zfish  1374 IKSTQQHMAAAHHLSAPALLLALSAEMKNNEPRSKSPP 1411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43867	NP_001284762.1	PH	942..1035	CDD:278594	44/96 (46%)
		PH1_PLEKHH1_PLEKHH2	944..1039	CDD:241436	45/98 (46%)
		PH	1050..1151	CDD:214574	39/100 (39%)
		PH	1053..1151	CDD:278594	38/97 (39%)
		MyTH4	1191..1410	CDD:214535	86/218 (39%)
		B41	1423..1643	CDD:214604	105/230 (46%)
		FERM_M	1527..1643	CDD:278785	50/125 (40%)
		PH-like	1639..1741	CDD:302622	46/109 (42%)
plekhh2	XP_001921439.4	APG6	41..>166	CDD:309295	49/158 (31%)
		PH1_PLEKHH1_PLEKHH2	644..740	CDD:241436	45/98 (46%)
		PH	753..844	CDD:275388	38/98 (39%)
		MyTH4	885..1040	CDD:214535	86/218 (39%)
		B41	1055..1284	CDD:214604	104/228 (46%)
		PH-like	1280..1379	CDD:327399	45/104 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	880	1.000	Inparanoid score	I381
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48143at33208
OrthoFinder	1	1.000	-	-		FOG0004352
OrthoInspector	1	1.000	-	-		otm24906
orthoMCL	1	0.900	-	-		OOG6_106231
Panther	1	1.100	-	-	O	PTHR22903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3701
SonicParanoid	1	1.000	-	-		X3070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000