DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43867 and plekhh1

DIOPT Version :9

Sequence 1:	NP_001284762.1	Gene:	CG43867 / 31031	FlyBaseID:	FBgn0264449	Length:	1852	Species:	Drosophila melanogaster
Sequence 2:	NP_001070987.1	Gene:	plekhh1 / 565914	ZFINID:	ZDB-GENE-061219-1	Length:	1433	Species:	Danio rerio

Alignment Length:	1666	Identity:	591/1666 - (35%)
Similarity:	810/1666 - (48%)	Gaps:	453/1666 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 INWQERCLELQLELHRSKNQAGRIRDMLREKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPK 340
            ::||:||:.|:.:|.|.:.|||.||.:|.|::.|||||||||::|||.||.:|..||::|..
Zfish    18 VDWQKRCIALETQLMRFRLQAGNIRHLLAERMQELEQRVIEADQRAESAEKQVHIMEEKLKS--- 79

  Fly   341 PPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLE 405
                                ::.|..:.:|....|:|....           ..||.:..:..||
Zfish    80 --------------------ANMQPSETENSLYRSYQELSN-----------QIQEKDLIVKRLE 113

  Fly   406 IQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKN------- 463
            .|:|:|..:|..:|..||.||||||:||..|||::|.:||.|::.|:|..:|:.:|::
Zfish   114 GQLEKQNLVRAQEAEIIEEKAAKIKDWVTFKLREMETENQQLKKANLKQTEQILMLQDKLQTLLE 178

  Fly   464 ---------HIANQSQRHSIVGP--------------VRNSLSLD-------------------- 485
                     |:...|..|....|              .|.:.|.|
Zfish   179 RPMSPAVDTHLVPSSPLHPPSCPGTPPAQEDCWRLPGCRLNSSADSKRKITEGCDSAFHSASLLP 243

  Fly   486 -VQDFTGSGSNPEH--------RRRSESLDPQEIIGRPL----TSSYPHHQHRRNLSMEPQELER 537
             :||...|..:.:.        :..:|.::|...:.|..    .|...|.....|.....|.|..
Zfish   244 MLQDKADSPKSSQDGVDATSTVKESAEGVEPSFGVMRDRAMGGASDRDHSSDELNSKFRSQCLRS 308

  Fly   538 NLVAAVDGLTLAPLSSISNKA-----PGGVPTESGVVTRP------------------------- 572
            :          :..||.|:.|     |||..|.:.....|
Zfish   309 S----------SSSSSSSSSAYETPGPGGFDTPTPTPKSPPPVSLSPPLTRLPLSCPFPLALPLG 363

  Fly   573 ---------------DSSDTDTAH------------------DYAEIYTPSC------------- 591
                           ||......|                  |.....:|||
Zfish   364 TSMTLPKVRTPLTPRDSIQLVKKHHSQPQPGLERLHQVNVSIDIGNCGSPSCHSLVPGSAPSHGL 428

  Fly   592 ----------EKLPAWMKNNPALMASGGNSSTTTTTTSELGVP-----RPPTPPLHRFPSWEAKI 641
                      |.:...::.:....|...:.......|.||.:.     :|||||||||||||::|
Zfish   429 EETDIDEGTPESMEVVVEGSEITEAQPNDGDLLDGLTKELEMMDPEALKPPTPPLHRFPSWESRI 493

  Fly   642 YQVANDGL--AGAGTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDGHGTLGS 704
            |.||..|:  :.|..|..|.                    ||           :.|...|.|.|
Zfish   494 YAVAKLGMRVSEACLGAKTI--------------------GR-----------VSTQPQHSTTG- 526

  Fly   705 TPGTPLPPSRQQQTASGGFCDISVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHAVMLTHHSH 769
             |.|.|.           :.:||||||:|:||:|:||.|:|.    .||.|..||
Zfish   527 -PFTHLI-----------YKNISVPVYSTLKGKATQISSVPL----PDDDSGSED---------- 565

  Fly   770 NSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTPSSRINQHL 834
            :|||..:..|||                |.|.|:
Zfish   566 DSSSLASLHTST----------------LGPDKK------------------------------- 583

  Fly   835 QPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLP-SPLQHMRGTVISDLSFE 898
                                                       ||.| ||....||...|.:|.|
Zfish   584 -------------------------------------------GSTPGSPRAVKRGVSTSSISSE 605

  Fly   899 SGLSDDYALPPDAVS-ESTCMDASMPSLLMRQSYVDSPSKKIESLEKMGHLAKLGGKLKTWRKRW 962
            |    |||:||||.| :|.|.:..  ..:.|.|.....|...|:|||.|:|.|:|.::|.|::||
Zfish   606 S----DYAIPPDAYSLDSDCSEPE--HKVQRTSSYSCESVGPETLEKTGYLLKMGSQVKAWKRRW 664

  Fly   963 FVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSHATMDDWI 1027
            |:|:||.:.|:||..||.||||||::|:..|.|.|.|||.||::.|.||.:||.|||...::|||
Zfish   665 FILRNGEILYYKSPSDVIRKPQGQMELNSSCHIARGEGAQTFQLITEKKTFYLAADSPNILEDWI 729

  Fly  1028 RVLQNVQRRNATKLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAETNPLGQIN 1092
            ||||||.:..|:..:....:.|||.:||:||||:||.|..||.|:||:|.|::...:..||||:.
Zfish   730 RVLQNVLKVQASGPISMDKEVKPTARGWLTKVKHGHSKLVWCALIGKVFYYYRNQEDKFPLGQLR 794

  Fly  1093 MRDARVEEVEHVSDSDSEEREDAAQD--QARLTVAIYPAHQGPTYLILSGKPERDNWLYHLTVVS 1155
            :|:||||||:...||| |:.|...:.  .:..|:.::|..|.||||::..|.|:|.|||||||.:
Zfish   795 VREARVEEVDRSCDSD-EDYEAGGRGFLSSHFTLVVHPKEQSPTYLLVGTKQEKDTWLYHLTVAA 858

  Fly  1156 GGGPS--AGTQYEQLVQKLMETDGDPNCVLWRHPILLHTKDTITAPLSSMHTETMQPEAIKLFKS 1218
            |...|  .||::|||:.||::.||..:..||:..:|..:|:.:..||:::.:|.:|.||||||||
Zfish   859 GSSASLRVGTEFEQLIGKLLDVDGVSDSALWKREVLCFSKEGLRYPLTTLPSEALQTEAIKLFKS 923

  Fly  1219 IQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQKLSVGVQVNKKLG 1283
            .|||::|.|..|.||||..|||||||..|..||||.||.|.|||||:
Zfish   924 CQLFINVLVESPSIDYHTSLAQNALQVCLTHPELQNEMYCQLIKQTN------------------ 970

  Fly  1284 KQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPVYSFVQGWQLLALA 1348
                    |.|                                      |..|:..|.||||:|.
Zfish   971 --------CRT--------------------------------------PHNYALTQCWQLLSLC 989

  Fly  1349 VSLFVPRSSRLLWYLKLHLSRNADTKTETGKYAAYCERALERTLKNGGRETKPSRMEVLSILLKN 1413
            |:||:|: ...||||:.:|.||||.:||.||||.||:|::||||:||.||.||||||:|||||:|
Zfish   990 VALFLPQ-HHFLWYLRQYLQRNADPRTEVGKYAVYCQRSVERTLQNGEREAKPSRMEILSILLRN 1053

  Fly  1414 PYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELGTR-DATNGFCLFSDDPIEKDLEH 1477
            |||||||.:||||.||:||:||.||||||:|||..|:....|.| ...:||.||:|||..|||||
Zfish  1054 PYHHSLPFSIPVHFMNNTYEVVGFDGSTTVEEFLNTVNQRTGMRKPQISGFALFTDDPSGKDLEH 1118

  Fly  1478 YLEPLAKLCDVISKWETALREKGSGKFENSRVIQLSYKNRLYWKHTIKCETDKERLLLCYQTNSQ 1542
            .|:|..|:||||||||.||:|...||:|.:|.::|:||:||.::...|.||::|||||.||.|.:
Zfish  1119 CLQPANKICDVISKWEQALKELHPGKYEGTRTVRLTYKSRLCFRAQAKGETERERLLLAYQVNDE 1183

  Fly  1543 IVQGRFPLSRELALELASLMSQIDMGDYSLEKSRDVGVG----------LKGLDKFYPYRYRDAL 1597
            ::||.||:|:|||||:|:||:|::.||  |:::....||          |:.|::|||.||:...
Zfish  1184 VLQGHFPVSKELALEVAALMAQVEYGD--LDRAAMSPVGSPQPKTQQTLLQVLERFYPKRYKQEC 1246

  Fly  1598 GAEQLKDVQELLV-SKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQSPESNTASGATP 1661
            ..|||:::.|.|| :||.:|:|.:..:|||||||..||||.|||.||.|||  .|.|:.  ..|.
Zfish  1247 SVEQLRELGERLVATKWSVLRGCTASECVRIYLTVARKWPLFGAKLFNAKP--LPPSSL--DRTQ 1307

  Fly  1662 VAWLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFMLVVS--HDDGGGGE--QKLLFAMS 1722
            | ||||.||.|:||:. ||.|:..|||.||:|||||::|||||||  .|...|.:  .||||||:
Zfish  1308 V-WLAVNEDGLSVLDY-TMYPLVTYPYQSVITFGGCKEDFMLVVSLIKDQALGKKTVDKLLFAMA 1370

  Fly  1723 KPKILEITLLIADYMNALGHTVPGT---PQMNSLTRNGSHR 1760
            ||||||:|||||.|:|....::||.   .|.::|...|..:
Zfish  1371 KPKILELTLLIASYINYWTSSLPGASNQTQSSTLGAQGDKK 1411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43867	NP_001284762.1	PH	942..1035	CDD:278594	52/92 (57%)
		PH1_PLEKHH1_PLEKHH2	944..1039	CDD:241436	50/94 (53%)
		PH	1050..1151	CDD:214574	47/102 (46%)
		PH	1053..1151	CDD:278594	45/99 (45%)
		MyTH4	1191..1410	CDD:214535	91/218 (42%)
		B41	1423..1643	CDD:214604	118/231 (51%)
		FERM_M	1527..1643	CDD:278785	60/126 (48%)
		PH-like	1639..1741	CDD:302622	61/105 (58%)
plekhh1	NP_001070987.1	GBP_C	<47..156	CDD:303769	48/142 (34%)
		coiled coil	145..156	CDD:293879	5/10 (50%)
		PH	644..737	CDD:278594	52/92 (57%)
		PH1_PLEKHH1_PLEKHH2	646..741	CDD:241436	50/94 (53%)
		PH	755..854	CDD:214574	45/99 (45%)
		MyTH4	896..1050	CDD:214535	91/218 (42%)
		B41	1063..1293	CDD:214604	118/231 (51%)
		FERM_M	1168..1293	CDD:278785	60/126 (48%)
		FERM_C-lobe_PLEKHH1_PLEKHH2	1289..1390	CDD:241360	61/106 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4294
eggNOG	1	0.900	-	-		E1_KOG0248
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121939
Inparanoid	1	1.050	880	1.000	Inparanoid score	I381
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48143at33208
OrthoFinder	1	1.000	-	-		FOG0004352
OrthoInspector	1	1.000	-	-		otm24906
orthoMCL	1	0.900	-	-		OOG6_106231
Panther	1	1.100	-	-	LDO	PTHR22903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3701
SonicParanoid	1	1.000	-	-		X3070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860