Protein Alignment CG43867 and Plekhh2

DIOPT Version :10

• Sequence 1: NP_001284762.1
• Gene: CG43867 / 31031
• FlyBaseID: FBgn0264449
• Length: 1852
• Species: Drosophila melanogaster
• Sequence 2: NP_001178699.3
• Gene: Plekhh2 / 313866
• RGDID: 1304935
• Length: 1488
• Species: Rattus norvegicus
• Alignment Length: 1768
• Identity: 582/1768 - (32%)
• Similarity: 803/1768 - (45%)
• Gaps: 566/1768 - (32%)

  Fly   276 INWQERCLELQLELHRSKNQAGRIRDMLREKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPK 340
            |:|:|||:.|:.:|.:.:.||.:||::|.:|:.:||::||:||.:||.|..:|:.||::|..
  Rat    11 IDWKERCVALEAQLMKFRVQASKIRELLADKMQQLERQVIDAERQAERAFQEVQVMEEKLKA--- 72

  Fly   341 PPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLE 405
                            ..|.:...|.:....|......               .||.:..|.:|.
  Rat    73 ----------------ANIQTSESETRLYKKCQDLESV---------------MQEKDDLIQNLA 106

  Fly   406 IQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLR---------------------E 449
            :::|||:|:|:.:|:.||.|||||||||..||.:||.:||.||                     |
  Rat   107 LRLEEQKQVRIKEAKTIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQTEELRAIQSKLQELQE 171

  Fly   450 QNV---------------------------------------------------KCNQQLELLKN 463
            :.|                                                   :|.:::|:.:.
  Rat   172 KKVSCVSSPKPSEGQRLSSLTFGCFLSRAKSPPCAVRSEEASKMASSEPEFAEARCVEEMEIAEK 236

  Fly   464 HIANQSQRHSIVGPVRNSLSL------------DVQDFTGSGSNPEH----------------RR 500
            ...||.|.:|     |:...|            ....|...|..|||                :.
  Rat   237 PADNQVQENS-----RSQRKLLETSCGSEHNRKTGASFVADGGTPEHSGLPVSDWSSDDDDGSKG 296

  Fly   501 RSESLDPQEI----------IGRPLTSSY------------------PHHQHRRNLSMEPQELER 537
            ||:|.....:          .|||.:.:|                  ...||::..|.:.:
  Rat   297 RSKSRCTSTLSSHTSEEGGQCGRPGSEAYLTASDDSSSIFEEETFDANRPQHKKLYSWQQK---- 357

  Fly   538 NLVAAVDGLTLAPLSSISNKAPGGVPTESGVVTRPDSSD----------TDTAHDYAEIYTPSCE 592
                       ||..:.||.|.|.  ::|.|..|..|||          .|.:...:|..|||..
  Rat   358 -----------APWKAPSNLAKGS--SQSEVKQRDSSSDELNKKFQSQRLDYSSSSSEANTPSPI 409

  Fly   593 KLPAWMKNNPALMASGGN-------------------SSTTTTTTSELGVP-------------- 624
            ..||....:|..:...|.                   |.:...|...|..|
  Rat   410 LTPALTPKHPNSLPGKGTPLVPPPFLPPPKLRIPNVFSISVALTKRHLSQPQLCSDRMFGMNRNA 474

  Fly   625 -------------------------------------------------------------RPPT 628
                                                                         :|||
  Rat   475 ISMIRPLRPQETDLDMVDGDRAEAVDIMDTGCGDLFSYDSQDPPSAEDPENSEATKKASCSKPPT 539

  Fly   629 PPLHRFPSWEAKIYQVANDGLAGAGTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGI 693
            ||||||||||::||.||..|                    |:.....|:.|..::.
  Rat   540 PPLHRFPSWESRIYAVAKSG--------------------IRVSEAFNMENANKNA--------- 575

  Fly   694 GTGDGHGTLGSTPGTPLPPSRQQQTASGGFC-----DISVPVYATVKGRASQIRSMPFTGDSSDD 753
                              .|....:.:|.:.     :::.|||.|:||:|:||.:.||..|||
  Rat   576 ------------------ASLLSHSVAGPYMSLIYKNVTTPVYTTLKGKATQISTSPFLDDSS-- 620

  Fly   754 SSDGEDHAVMLTHHSHNSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHI 818
            .||.||                       ||.:| |:|...|.:.|   |||..||:..|
  Rat   621 GSDEED-----------------------GSRAS-SRSQSESETRS---RSGPNSPRAMK----- 653

  Fly   819 QSRTSTTPSSRINQHLQPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSP 883
                                                                             
  Rat   654 ----------------------------------------------------------------- 653

  Fly   884 LQHMRGTVISDLSFESGLSDDYALPPDAVSESTCMDASMP-SLLMRQSYVDSPSKKIESLEKMGH 947
                ||  :||.|     ..|||:||||.|..|  :.|.| ..|::.....|.:.|.|.|||.|:
  Rat   654 ----RG--VSDSS-----EGDYAIPPDAYSIDT--ECSQPEQKLLKTCSTSSDNGKSELLEKSGY 705

  Fly   948 LAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKV 1012
            |.|:.|:|||||:||||||.|.|.|::|..||.|||||.|:|...|.|.|.:...|.::.|.|..
  Rat   706 LLKMSGRLKTWRRRWFVLKGGELLYYRSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHT 770

  Fly  1013 YYLTADSHATMDDWIRVLQNVQRRNATKLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFL 1077
            |||||||...:::||:|.|||.|..|...|..:.:.||||:|.:||||:|:.|:.||.|:||...
  Rat   771 YYLTADSPNILEEWIKVFQNVLRVQAANPLCLQPEGKPTVKGLLTKVKHGYSKRVWCTLVGKCLY 835

  Fly  1078 YFKAPAETNPLGQINMRDARVEEVEHVSDSDSE-EREDAAQDQARLTVAIYPAHQGPTYLILSGK 1141
            ||::..:..|||||.:.:|:||||:...|||.: |...........|:.::|..||||||::..|
  Rat   836 YFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYETSGRCLLSTHYTIIVHPKDQGPTYLLIGSK 900

  Fly  1142 PERDNWLYHLTVVSG-GGPSAGTQYEQLVQKLMETDGDPNCVLWRHPILLHTKDTITAPLSSMHT 1205
            .|::.|||||||.:| ...:.|:::||||.||:..:|:|:..:||||:|.|:|:.|..||:|:.:
  Rat   901 HEKEAWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPMLCHSKEGILCPLTSLPS 965

  Fly  1206 ETMQPEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQ 1270
            |.:|.|||||||:.|||::..|:.|.||||:.|||:|||..|..||||:|:.|.|||||.|
  Rat   966 EALQTEAIKLFKTCQLFINAVVDSPAIDYHISLAQSALQVCLTHPELQSEICCQLIKQTRR---- 1026

  Fly  1271 KLSVGVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPV 1335
                            ||                    |.|.:.|
  Rat  1027 ----------------RQ--------------------QQNQAGP-------------------- 1035

  Fly  1336 YSFVQGWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETGKYAAYCERALERTLKNGGRETK 1400
               :||||||||.|.||:|... .||.|::||.|:||::||.||||.||:|.:||||:||.||.:
  Rat  1036 ---LQGWQLLALCVGLFLPHHP-FLWLLQVHLQRSADSRTEFGKYAIYCQRCVERTLQNGDREAR 1096

  Fly  1401 PSRMEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELGTR-DATNGFC 1464
            |||||:||.||:||||||.|.:||||.||..||||.||.|||:|||..||..:.|.| .|.:||.
  Rat  1097 PSRMEILSTLLRNPYHHSRPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFA 1161

  Fly  1465 LFSDDPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFENSRVIQLSYKNRLYWKHTIKCETD 1529
            ||:|||..:||||.|:...|:||:|||||.|.:|...||.|.||.::|:||||||:....:.|||
  Rat  1162 LFTDDPSGRDLEHCLQGNIKICDIISKWEQASKELQPGKCEGSRTVRLTYKNRLYFSMQARGETD 1226

  Fly  1530 KERLLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGDYSLEKSRDVG---------VGLKG- 1584
            :|:|||.||||.||:.|.|||:::||||:|:|::|:|:||:....|...|         ..||.
  Rat  1227 REKLLLLYQTNEQIINGLFPLNKDLALEMAALLAQVDIGDFERPFSTPAGHVTNQCKANQTLKQV 1291

  Fly  1585 LDKFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQ 1649
            ::||||.|||:....|||:.:.:.|.::||.|:|.||.||:|||||..||||:|||.||.|||
  Rat  1292 VEKFYPKRYREGCSEEQLRQLYQRLSTRWMALRGHSTTDCIRIYLTVARKWPFFGAKLFLAKP-- 1354

  Fly  1650 SPESNTASGATPVA------WLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFMLVVSHD 1708
                     .||.:      ||||.|:.|::||.::|..|..|.|.|||||||.|:|||:|:|..
  Rat  1355 ---------ITPSSLGNNFIWLAVHENGLSILEYTSMRLVTGYVYKSVMTFGGYQEDFMVVISTQ 1410

  Fly  1709 DGGGGEQKLLFAMSKPKILEITLLIADYMN-------ALGH-TVPG-------TPQMNSLTRNGS 1758
            ......:||||||:||||||||||||.|:|       |..| :.|.       .||..::   ||
  Rat  1411 AKDRPTEKLLFAMAKPKILEITLLIASYINNFYQQKAAFHHLSAPALLSAKVQEPQAKAM---GS 1472

  Fly  1759 HRSLRTSQRPNLG 1771
             :.|.::.||..|
  Rat  1473 -QPLLSNNRPTKG 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43867	NP_001284762.1	TPH	395..>462	CDD:464007	33/138 (24%)
		PH1_PLEKHH1_PLEKHH2	944..1039	CDD:241436	49/94 (52%)
		PH	1050..1151	CDD:214574	44/101 (44%)
		MyTH4	1191..1410	CDD:214535	92/218 (42%)
		FERM_F1_Max1_like	1420..1520	CDD:340614	57/100 (57%)
		B41	1423..1643	CDD:214604	119/230 (52%)
		PH-like	1639..1741	CDD:473070	55/114 (48%)
Plekhh2	NP_001178699.3	None