DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43867 and Plekhh2

DIOPT Version :9

Sequence 1:	NP_001284762.1	Gene:	CG43867 / 31031	FlyBaseID:	FBgn0264449	Length:	1852	Species:	Drosophila melanogaster
Sequence 2:	XP_036016351.1	Gene:	Plekhh2 / 213556	MGIID:	2146813	Length:	1540	Species:	Mus musculus

Alignment Length:	1792	Identity:	571/1792 - (31%)
Similarity:	798/1792 - (44%)	Gaps:	546/1792 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 PAST----PNSPRLLPRRAPRPPPIP------AKPNQVKADQQSKDAQARNSTTTTVQATVNPVL 241
            ||.|    || |:......|.|...|      |..|:||..:.|:..:...::    .|:..|:
Mouse     9 PAETARPLPN-PQKSAGERPEPTRTPGEVLCRASLNEVKIREDSRPMKCCKAS----YASTPPL- 67

  Fly   242 AALDAPDAPWPHFSTLTEHLDVHQVNNYGQALPQINWQERCLELQLELHRSKNQAGRIRDMLREK 306
             ::|        |....:||                         :..|||.:        .:..
Mouse    68 -SID--------FYLSLQHL-------------------------VSSHRSAS--------AKHH 90

  Fly   307 LTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPKPPPQQAQHPHSHSHPHQPIPSHPQEQQAKNH 371
            :.:||::||:||.:||:|..:|:.||::|..                   ..|.:...|.:....
Mouse    91 MQQLERQVIDAERQAEKAFQEVQVMEEKLKA-------------------ANIQTSESETRLYKK 136

  Fly   372 CSPSHQASGGATAGAAGSGLPPTQETEKTITSLEIQVEEQRQLRLHDARQIEAKAAKIKEWVNNK 436
            |......               .||.:..|.:|.:::|||:|:|:.:|:.||.|||||||||..|
Mouse   137 CQDLESV---------------MQEKDDIIQNLALRLEEQKQVRIQEAKIIEEKAAKIKEWVTVK 186

  Fly   437 LRDLEEQNQLLREQNVKCNQQLELLKNHIAN-QSQRHSIVGPVRNS-----------LS------ 483
            |.:||.:||.||..|....:::..:::.:.. |.::.|.|...:.|           ||
Mouse   187 LNELEVENQNLRFINQTQTEEIRAIQSKLQELQEKKISCVSSPKTSEGQRNLTFGCFLSRAKSPP 251

  Fly   484 --LDVQDFTGSGSNPEHRRRSESLDPQEIIGRPLTSSYPHHQ------HRRNLSMEPQELERNLV 540
              :..::.:...||.........::..||..:|..:....:.      |..:.|.| |..:....
Mouse   252 CVVRCEEVSKMASNEPEITEGRCVEEMEIAEKPADNQVQENSRSQRKLHETSCSSE-QNQKTRAS 315

  Fly   541 AAVDGLTL----APLSSISN--------------------------------------------- 556
            .|:||.|.    .|:|..|:
Mouse   316 FAMDGGTSQNSGVPVSDWSSDEDDGSKGRSKSRCTSTLSSHTSEEGGQCGRLGSEAYLTASDDSS 380

  Fly   557 ---------------------------KAPGGVP---TESGVVTRPDSSD----------TDTAH 581
                                       ||.|.:.   ::|||..:..|||          .|...
Mouse   381 SIFEEETFDGNRPEQKKLCSWQQKAPWKAQGNLAKGRSQSGVKEQDSSSDELNKKFHSQRLDYTS 445

  Fly   582 DYAEIYTPSCEKLPAWMKNNP-ALMASGGN-------------------SSTTTTTTSELGVP-- 624
            ..:|..|||....||.....| :|...||.                   |.:...|...|..|
Mouse   446 SSSEANTPSPILTPALTPRYPNSLPGKGGAPLVPPPFQPPPKLRVPNVFSISVALTKRHLSQPQL 510

  Fly   625 ----------------------------------------------------------------- 624

Mouse   511 CSDRMFGTNRNAISMIRPLRPQETDLDVVDGDGAEAVNRMDTGCDDGLFSYDSQDPPPCADDQEN 575

  Fly   625 ----------RPPTPPLHRFPSWEAKIYQVANDGLAGAGTGTSTAESTASQEPDIQDGMGTNLSN 679
                      :|||||||||||||::||.||..|:                          .:|.
Mouse   576 SEAPKKAPCNKPPTPPLHRFPSWESRIYAVAKSGI--------------------------RVSE 614

  Fly   680 GRRHGHGHGSGTGIGTGDGHGTLGSTPGTPLPPSRQQQTASGGFCDISVPVYATVKGRASQIRSM 744
            .....|.:.:...|                |..|......|..:.:::.|||.|:||:|:||.|.
Mouse   615 AFNMEHANKNSADI----------------LSYSAASLYTSLIYKNMTTPVYTTLKGKATQISSS 663

  Fly   745 PFTGDSSDDSSDGEDHAVMLTHHSHNSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESP 809
            ||..|||  .||.||            ||..::..|.|.:.|                |||..||
Mouse   664 PFLDDSS--GSDEED------------SSRSSSRLSESDARS----------------RSGPSSP 698

  Fly   810 KNAKARVHIQSRTSTTPSSRINQHLQPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANA 874
            :..|
Mouse   699 RAMK------------------------------------------------------------- 702

  Fly   875 LQPGSLPSPLQHMRGTVISDLSFESGLSDDYALPPDAVS-ESTCMDASMP-SLLMRQSYVDSPSK 937
                         ||  :||.|..|  ..|||:||||.. ::.|   |.| ..|::.......:.
Mouse   703 -------------RG--VSDSSAAS--ESDYAIPPDAYPIDAEC---SQPEQKLLKTCLASCDNG 747

  Fly   938 KIESLEKMGHLAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGAS 1002
            |.|.|||.|:|.|:..::|||::||||||.|.|.|:||..||.|||||.|:|...|.|.|.:...
Mouse   748 KNEPLEKSGYLLKMSVRVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQ 812

  Fly  1003 TFEIDTGKKVYYLTADSHATMDDWIRVLQNVQRRNATKLLLSRDDQKPTVQGWVTKVKNGHPKKC 1067
            |.::.|.|..|||||||...:::||:|||:|.|..|...|..:.:.||.|:|.:||||:|:.|:.
Mouse   813 TVQLATEKHTYYLTADSPNILEEWIKVLQSVLRVQAANPLCLQPEGKPAVKGLLTKVKHGYSKRV 877

  Fly  1068 WCVLLGKMFLYFKAPAETNPLGQINMRDARVEEVEHVSDSDSE-EREDAAQDQARLTVAIYPAHQ 1131
            ||:|:||:..||:...:..||||:.:.:|:||||:...|||.: |...........|:.::|..|
Mouse   878 WCMLVGKVLYYFRNQEDKFPLGQLKLWEAKVEEVDRSCDSDEDYETRGCYLLSTHYTIIVHPKDQ 942

  Fly  1132 GPTYLILSGKPERDNWLYHLTVVSGGGP-SAGTQYEQLVQKLMETDGDPNCVLWRHPILLHTKDT 1195
            |||||::..|.|::.|||||||.:|... :.|:::||||.||:..:|:|:..:||||:|.|:|:.
Mouse   943 GPTYLLIGSKHEKEAWLYHLTVAAGSNNINVGSEFEQLVCKLLNIEGEPSSQIWRHPMLCHSKEG 1007

  Fly  1196 ITAPLSSMHTETMQPEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICIL 1260
            |.:||:::.:|.:|.|||||||:.|||::.||:.|.||||:.|||:|||..|..||||.|:.|.|
Mouse  1008 ILSPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQVCLTHPELQNEICCQL 1072

  Fly  1261 IKQTSRHLGQKLSVGVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATP 1325
            ||||.|                    |||                    .|...|
Mouse  1073 IKQTRR--------------------RQL--------------------QNQPGP---------- 1087

  Fly  1326 IIDCKSNPPVYSFVQGWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETGKYAAYCERALER 1390
                         :||||||||.|.||:|... .||.|:|||.||||::||.||||.||:|.:||
Mouse  1088 -------------LQGWQLLALCVGLFLPHHP-FLWLLQLHLQRNADSRTEFGKYAIYCQRCVER 1138

  Fly  1391 TLKNGGRETKPSRMEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELG 1455
            |.:||.||.:|||||:||.||:||||||.|.:||||.||..||||.||.|||:|||..||..:.|
Mouse  1139 TQQNGDREARPSRMEILSTLLRNPYHHSRPFSIPVHFMNGLYQVVGFDASTTVEEFLNTLNQDTG 1203

  Fly  1456 TR-DATNGFCLFSDDPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFENSRVIQLSYKNRLY 1519
            .| .|.:||.||:|||..:||||.|:...|:||:|||||.|.:|:..||.|.||.::|:||||||
Mouse  1204 MRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGSRTVRLTYKNRLY 1268

  Fly  1520 WKHTIKCETDKERLLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGDYSLEKSRDVG----- 1579
            :....:.|||:|:.||.||||.||:.|.|||:::||||:|:|::|:|:||:....|...|
Mouse  1269 FSVQARGETDREKTLLLYQTNDQIINGLFPLNKDLALEMAALLAQVDIGDFERPFSTPAGPVTNQ 1333

  Fly  1580 ----VGLKG-LDKFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCVRIYLTCCRKWPYFG 1639
                ..||. :::|||.|||:....|||:.:.:.|.:|||.|:|.|..||:|||||..||||:||
Mouse  1334 CKANQTLKQVIERFYPKRYREGCSEEQLRQLYQRLSTKWMALRGHSAADCIRIYLTVARKWPFFG 1398

  Fly  1640 ACLFQAKPRQSPES--NTASGATPVAWLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFM 1702
            |.||.||| .:|.|  |..      .||||.|:.|::||.::|..|..|.|..:|||||.|:|||
Mouse  1399 AKLFFAKP-IAPSSLGNNC------VWLAVHENGLSILEYTSMRLVTSYMYKGLMTFGGYQEDFM 1456

  Fly  1703 LVVSHDDGGGGEQKLLFAMSKPKILEITLLIADYMNA 1739
            :|||........:||||||:|.||||||||||.|:|:
Mouse  1457 VVVSTQSKDRPTEKLLFAMAKHKILEITLLIASYINS 1493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43867	NP_001284762.1	PH	942..1035	CDD:278594	48/92 (52%)
		PH1_PLEKHH1_PLEKHH2	944..1039	CDD:241436	47/94 (50%)
		PH	1050..1151	CDD:214574	42/101 (42%)
		PH	1053..1151	CDD:278594	40/98 (41%)
		MyTH4	1191..1410	CDD:214535	93/218 (43%)
		B41	1423..1643	CDD:214604	117/230 (51%)
		FERM_M	1527..1643	CDD:278785	60/125 (48%)
		PH-like	1639..1741	CDD:302622	53/103 (51%)
Plekhh2	XP_036016351.1	Smc	<83..>301	CDD:224117	59/259 (23%)
		PH1_PLEKHH1_PLEKHH2	754..849	CDD:241436	47/94 (50%)
		PH-like	852..965	CDD:418428	47/112 (42%)
		MyTH4	1003..1158	CDD:214535	93/218 (43%)
		FERM_F1_PLEKHH2	1168..1270	CDD:340699	58/101 (57%)
		B41	1171..1402	CDD:214604	117/230 (51%)
		FERM_C-lobe_PLEKHH1_PLEKHH2	1398..1496	CDD:241360	53/103 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4766
eggNOG	1	0.900	-	-		E1_KOG0248
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	833	1.000	Inparanoid score	I453
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48143at33208
OrthoFinder	1	1.000	-	-		FOG0004352
OrthoInspector	1	1.000	-	-		otm42497
orthoMCL	1	0.900	-	-		OOG6_106231
Panther	1	1.100	-	-	O	PTHR22903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3701
SonicParanoid	1	1.000	-	-		X3070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860