DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43867 and Plekhh1

DIOPT Version :9

Sequence 1:NP_001284762.1 Gene:CG43867 / 31031 FlyBaseID:FBgn0264449 Length:1852 Species:Drosophila melanogaster
Sequence 2:NP_851418.2 Gene:Plekhh1 / 211945 MGIID:2144989 Length:1356 Species:Mus musculus


Alignment Length:1593 Identity:558/1593 - (35%)
Similarity:786/1593 - (49%) Gaps:403/1593 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 INWQERCLELQLELHRSKNQAGRIRDMLREKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPK 340
            |:||:|||.|:.:|.|.:.||.:||::|.:|:.|||||::|||:|||.||.:|..||:::.    
Mouse    11 IDWQKRCLSLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKIK---- 71

  Fly   341 PPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLE 405
              ....:...|....||..    ||.                        |...|..::.|:.|:
Mouse    72 --LSNLKSVDSTGTLHQKY----QEL------------------------LRAVQGKDELISQLQ 106

  Fly   406 IQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQL------------ 458
            .|:|:|:|.|..:|:.::.|||||||||..||.:||.:||.|:    .|||||            
Mouse   107 AQLEKQKQTRAEEAKIVQEKAAKIKEWVTVKLAELEMENQQLK----TCNQQLVEQVAALQDALE 167

  Fly   459 --------ELL-----------------KNHIANQSQRHSIVGPV------------RNSLS--L 484
                    |||                 ...:...|..|:.:..|            |:|||  .
Mouse   168 DLRMTPSEELLVVPEGTPERDPVPSGPSDQPVEQDSNPHTQILKVAVPTPSLGTLQSRDSLSEAR 232

  Fly   485 DVQDFTGSGSNPEHRRRSESL--------DPQEIIGRPLTSSYPHHQHRRNLSMEPQELERNLVA 541
            .::|...|..:|.....:::|        .|.::..:|....:....:|           .:||.
Mouse   233 SLEDLRFSMVHPGETAEAKTLQSHLQKEGSPSQLCMKPGNPKHGSASYR-----------ESLVT 286

  Fly   542 AVDGLTLAPLSSISNKAPG-----------GVPTESGVVTRPDSSDTDTAHDYAE---------- 585
            |..|......:|.....||           .:|.:|..|.:...|.......:.:          
Mouse   287 AQGGTFPGTKTSAREGGPGSSLTLPKVRAPSIPRDSFQVAKRHHSQPQVGPGHCDHVVSIEIGAL 351

  Fly   586 --IYTPSCEKLPAWMK--------NNPALMASGGNSSTTTTTTS-------ELGVPRPPTPPLHR 633
              :::|...|..|..|        ...||..||......:..:.       || ..:||||||||
Mouse   352 SALHSPGSSKSEARAKVREEAEKMEMEALPPSGKQEERESLKSRRGELEDVEL-ENKPPTPPLHR 415

  Fly   634 FPSWEAKIYQVANDGLAGAGTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDG 698
            |||||::||.:|..|:                       ..:.:|:.|.:...:.||        
Mouse   416 FPSWESRIYAMATSGM-----------------------QLSEVSSRRSNAACYASG-------- 449

  Fly   699 HGTLGSTPGTPLPPSRQQQTASGG--FCDISVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHA 761
                        |.:.....|..|  :.:::||||..:||:|:||.::||.     |.|.|.|  
Mouse   450 ------------PSALAFPGAFSGLVYKNVTVPVYTALKGKATQISNVPFV-----DESSGSD-- 495

  Fly   762 VMLTHHSHNSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTP 826
                         |:..:..|...|.|....:        |.||..||:..|             
Mouse   496 -------------DDCGSQASFRMSVPCSEYR--------KTSGLGSPRAIK------------- 526

  Fly   827 SSRINQHLQPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTV 891
                                                                         ||..
Mouse   527 -------------------------------------------------------------RGVS 530

  Fly   892 ISDLSFESGLSDDYALPPDAVSESTCMDASMPSLLMRQSYVDSPSKKIESLEKMGHLAKLGGKLK 956
            :|.||.|.    |||:||||.|..:  |.|.|...::::  .|.|...|:|||.|:|.|:|.::|
Mouse   531 MSSLSSEG----DYAIPPDACSLDS--DYSEPEHKLQRT--SSYSTDGEALEKSGYLLKMGSRVK 587

  Fly   957 TWRKRWFVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSHA 1021
            ||::|||||:.|.:.|:||..||.||||||:.|:..|:|.|.|.|.||::.:|.|.|||||:|.:
Mouse   588 TWKRRWFVLRQGQILYYKSPSDVIRKPQGQVDLNSHCQIVREEEAQTFQLISGNKTYYLTAESPS 652

  Fly  1022 TMDDWIRVLQNVQRRNAT-KLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAET 1085
            .:::||||||::.:...| ...|.:...||||:||:||||:||.|..||.|:||.|.|:::..:.
Mouse   653 LLEEWIRVLQSLLKVQVTGPPALHQGGTKPTVKGWLTKVKHGHSKLVWCALVGKTFYYYRSHEDK 717

  Fly  1086 NPLGQINMRDARVEEVEHVSDSDSEEREDAAQDQARL-----TVAIYPAHQGPTYLILSGKPERD 1145
            .|||.:.::||.:|||:...||| |:.|  |....||     |:.|:|....||||::..|.|:|
Mouse   718 RPLGCLPVQDAHIEEVDRSCDSD-EDYE--AGGTGRLLSSHCTLVIHPPEHSPTYLLIGTKHEKD 779

  Fly  1146 NWLYHLTVVSGG-GPSAGTQYEQLVQKLMETDGDPNCVLWRHPILLHTKDTITAPLSSMHTETMQ 1209
            .|||||||.:|| ....||.||||:.|||:.:|:|:..|||||:|.::::.:.|.|:::.:|.:|
Mouse   780 TWLYHLTVAAGGSNAKVGTVYEQLIGKLMDGEGNPDSPLWRHPMLCYSQEGLCASLTTLPSEALQ 844

  Fly  1210 PEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQKLSV 1274
            .||:|||||.|||::|.|....:||||.|||.|||..|..||||:|:.|.|:||           
Mouse   845 TEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQ----------- 898

  Fly  1275 GVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPVYSFV 1339
                                                                |.|:. |..||.:
Mouse   899 ----------------------------------------------------ISCRP-PQKYSLM 910

  Fly  1340 QGWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETGKYAAYCERALERTLKNGGRETKPSRM 1404
            |.||||||...||:|: ...|||:|..|.|:||.::|||:||.||:||:||||:.|.||.:||||
Mouse   911 QCWQLLALCAPLFLPQ-HHFLWYVKQQLQRHADPRSETGQYAIYCQRAVERTLQTGEREARPSRM 974

  Fly  1405 EVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELGTR-DATNGFCLFSD 1468
            ||:||||:||:|||||.:||||..|.|||||.||||:|::||...|..|.|.| .:.:||.||:|
Mouse   975 EVVSILLRNPFHHSLPFSIPVHFANGTYQVVGFDGSSTVDEFLQRLNQETGMRKPSQSGFALFTD 1039

  Fly  1469 DPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFE-NSRVIQLSYKNRLYWKHTIKCETDKER 1532
            ||..:||||.|:...|:||.|||||..|:|...||.| .:||::|.||||||::..:|.||::||
Mouse  1040 DPSGRDLEHCLQGRVKICDAISKWEQTLKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETERER 1104

  Fly  1533 LLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGDYSLEKSRDVGVG-----------LKGLD 1586
            |||.:|.:.:||.||||:::|||||:|:||:|::.||  |||....|.|           .:.||
Mouse  1105 LLLAFQASGEIVAGRFPVTKELALEMAALMAQVEYGD--LEKPTLPGPGGTPPTKAQHLLQQVLD 1167

  Fly  1587 KFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQ-S 1650
            :|||.|||:....|||:.:.:::.:||..|:|.|..:|:|||||..||||.|||.||.|:|.| |
Mouse  1168 RFYPRRYRNGAPPEQLRHLADMMATKWAALQGCSPPECIRIYLTVARKWPLFGAKLFAAQPAQLS 1232

  Fly  1651 PESNTASGATPVAWLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFMLVV-SHDDGGGGE 1714
            |:.||      |.|:||.||.:::|:..||.....||||||.|||||:||||||: |..|...|:
Mouse  1233 PKENT------VVWIAVNEDGVSILDHRTMQVNITYPYSSVTTFGGCRDDFMLVIRSIPDQSSGK 1291

  Fly  1715 ---QKLLFAMSKPKILEITLLIADYMNALGHTV 1744
               .||.|.|..|||.|.||::|.|||....||
Mouse  1292 TRIDKLTFRMPAPKITETTLMMASYMNHCSATV 1324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43867NP_001284762.1 PH 942..1035 CDD:278594 49/92 (53%)
PH1_PLEKHH1_PLEKHH2 944..1039 CDD:241436 47/94 (50%)
PH 1050..1151 CDD:214574 48/105 (46%)
PH 1053..1151 CDD:278594 45/102 (44%)
MyTH4 1191..1410 CDD:214535 82/218 (38%)
B41 1423..1643 CDD:214604 115/232 (50%)
FERM_M 1527..1643 CDD:278785 59/126 (47%)
PH-like 1639..1741 CDD:302622 54/106 (51%)
Plekhh1NP_851418.2 Smc 15..>177 CDD:224117 64/199 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 179..203 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..314 10/68 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..414 15/60 (25%)
PH1_PLEKHH1_PLEKHH2 575..670 CDD:241436 47/94 (50%)
PH 682..785 CDD:214574 48/105 (46%)
MyTH4 826..980 CDD:214535 82/218 (38%)
Ubiquitin_like_fold 990..1096 CDD:421700 56/105 (53%)
B41 993..1224 CDD:214604 115/232 (50%)
FERM_C-lobe_PLEKHH1_PLEKHH2 1220..1321 CDD:241360 54/106 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 139 1.000 Domainoid score I4766
eggNOG 1 0.900 - - E1_KOG0248
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H121939
Inparanoid 1 1.050 833 1.000 Inparanoid score I453
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004352
OrthoInspector 1 1.000 - - otm42497
orthoMCL 1 0.900 - - OOG6_106231
Panther 1 1.100 - - LDO PTHR22903
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3701
SonicParanoid 1 1.000 - - X3070
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.850

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