Protein Alignment CG43867 and max-1

DIOPT Version :10

• Sequence 1: NP_001284762.1
• Gene: CG43867 / 31031
• FlyBaseID: FBgn0264449
• Length: 1852
• Species: Drosophila melanogaster
• Sequence 2: NP_001367137.1
• Gene: max-1 / 179794
• WormBaseID: WBGene00003143
• Length: 1099
• Species: Caenorhabditis elegans
• Alignment Length: 1384
• Identity: 347/1384 - (25%)
• Similarity: 577/1384 - (41%)
• Gaps: 364/1384 - (26%)

  Fly   414 LRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKNHIANQSQRHSIVGPV 478
            ||..:..::.||:::|:.||..::::||:||:.||.||::|..||::|::
 Worm     9 LRSPEDEELLAKSSRIRLWVTKRMKELEDQNERLRAQNLRCTTQLQMLRS--------------- 58

  Fly   479 RNSLSLDVQDFTGSGSNPEHRRRSESLDPQEIIGRPLTSSYPHHQHRRNLSMEPQELERNLVAAV 543
                      ||         .:|..:..:..:.|.:|.:.|..:            :.|..:..
 Worm    59 ----------FT---------EKSRKIKAEMEMSRSITGTLPVLR------------DENRTSDD 92

  Fly   544 DGLTLAPLSSISNKAPGGVPTESGVVTRPDSSDTDTAHDYAEI--YTPSCEKLPA--WMKNNPAL 604
            .|||                          |.|.|.......|  .||..::..|  .:||
 Worm    93 SGLT--------------------------SDDADRKQMSVSISECTPRVQRKAARTMLKN---- 127

  Fly   605 MASGGNSSTTTTTTSELGVPRPPTPPLHRFPSWEAKIYQVANDGLAGAGTGTSTAESTASQEPDI 669
             .|.|:|::.::...:...|.|....:|...:....:...|.|                 .|.||
 Worm   128 -TSQGSSTSESSPCEDEAKPMPLPRRIHPTATERDSLNSYAED-----------------YEYDI 174

  Fly   670 QDGMGTNLSNGRRHGHGHGSGTGIGTGDGHGTLGSTPGTPLPPSRQQQTASGGFCD-------IS 727
            ::      |:..||                             ..|.:..:..:.|       ::
 Worm   175 EE------SSFERH-----------------------------EEQVRNENEKYVDYVNLHEFVA 204

  Fly   728 VP----VYA-TVKGRASQIRSMPFTGDSSDDSSDGEDHAVMLTHHSHNSSSTDN-----TETSTS 782
            :.    ||: .||.|:::...:|                   ...||.....:|     .|...|
 Worm   205 IKDDKVVYSEIVKHRSTEKEYLP-------------------ALPSHQPRQWENRLIQAAEKCLS 250

  Fly   783 GSASSPSKSLKTSSSLSP---------AKRSGSESPKNAKARVHIQSRTSTTPSSRINQHLQPSQ 838
            ....:.|:...|..|:||         :..:.:|||.:.|:     |:.|...|.|:..|
 Worm   251 VIDGADSEGTSTGPSVSPYHVSDVSRISSNNRTESPGSRKS-----SKLSRNSSPRVPSH----- 305

  Fly   839 HQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTVISDLSFESGLSD 903
                      |.::.||                                 ...|.||.    |..
 Worm   306 ----------HSYEDGA---------------------------------AYAIRDLC----LGS 323

  Fly   904 DYALPPDAVSESTCMDASMPSLLMRQSYVDSPSKKIESLEKMGHLAKL-GGKLKTWRKRWFVLKN 967
            ||.|||||  .|.|...:..|   |.|.:  ||:  |::||.|:..:| ..::|:.::|:.|.||
 Worm   324 DYYLPPDA--SSRCSGGTPTS---RTSLI--PSR--ETMEKSGYWTQLTDSRIKSLKRRYVVFKN 379

  Fly   968 GSLNYWKSQHDVQRKPQGQIQLDEVCRINRAE---GASTFEIDTG-KKVYYLTADSHATMDDWIR 1028
            |.:::::..::...:|..:|.:.::..:.:.|   .|..|::.|. .|:.::| :|..|..||:.
 Worm   380 GQISFYRKHNNRDEEPASKISISDIRSVTKLEQQGAAYAFQLITSTDKMNFMT-ESERTTHDWVT 443

  Fly  1029 VLQNVQRRNATKLLLSR-DDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAETNPLGQIN 1092
            :|....:....:.:.|| .....::.||:|:||.|..||.:..|:.:..::||...:..|.|.:.
 Worm   444 ILSAAIKATTLREMASRVTPIDASISGWLTRVKCGLSKKVFAALVNQKLMFFKNSNDLVPNGFLC 508

  Fly  1093 MRDARVEE----VEHVSDSDSEE----REDAAQDQARLTVAIYPAHQGPTYLILSGKPERDNWLY 1149
            ::.|::.|    .|..|.|..|:    :|...|.:...::.:..|::.|.||||....:::.|||
 Worm   509 LQGAQISEKHNGTEEYSGSSDEQLETTKEHPNQRKNNDSLCVQIANEDPVYLILRTSEDKEKWLY 573

  Fly  1150 HLTVVSGGGPSAGTQYEQLVQKLMETDGDPNCVLWRHPILLH----TKDTITAPLSSMHTETMQP 1210
            :|...||.....||.:|.|||::|..:...:..||:..:...    .|||:|   |..|::  :.
 Worm   574 YLKSASGTAALCGTPFEILVQRMMAENVANDSPLWKDLLFASGEEIPKDTMT---SVDHSD--RK 633

  Fly  1211 EAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQKLSVG 1275
            :.:::.::.|||:||.:......||:.||||.|..|:....|:.|:...|||.||
 Worm   634 KTLEIARACQLFVSVLMRAQATQYHIDLAQNILSTAVQQEYLRNEVYSQLIKMTS---------- 688

  Fly  1276 VQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPVYSFVQ 1340
                                                ||.|..:                     |
 Worm   689 ------------------------------------GSMPFGL---------------------Q 696

  Fly  1341 GWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETG--KYAAYCERALERTLKNGGRETKPSR 1403
            ||:||||.:.||:|:...|||.||.|:||..|...|:.  :.|.:||.||:|.|:.|||:..|||
 Worm   697 GWKLLALTIPLFLPKQYSLLWLLKRHISRWVDLPNESDETRMAIFCESALDRCLRVGGRQEGPSR 761

  Fly  1404 MEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELGTRDA-TNGFCLFS 1467
            :||.|:|.::......||:|.|.:.||.||:|.|||||.|.:..::|..:||.|.| .:|:.|:.
 Worm   762 LEVTSVLTRDVTRTKFPHSISVKLPNSEYQIVEFDGSTEIGQCLSSLCLKLGMRPALLSGYALYM 826

  Fly  1468 DDPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFENSRVIQLSYKNRLYWKHTIKCETDKER 1532
            :||:...| ..|:...||||.:|.|||..|:...|:..:.....||.:.|.||.|....||..||
 Worm   827 NDPMTHSL-LLLKGKQKLCDALSTWETRSRDAQRGRVISDCAAALSLRMRHYWGHLALTETPIER 890

  Fly  1533 LLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGD--YSLEKSRDVGVGLKGLDKFYPYRYRD 1595
            ..|.::.:.:||.||.|||.:|...||:|.:|:..||  .||...:...:.    .:|||.:..|
 Worm   891 QFLVWRASEEIVNGRIPLSNQLCESLAALYAQMVFGDANQSLSDQQFEFIS----QRFYPSKMLD 951

  Fly  1596 ALGAEQLKDVQELLVSKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQSPESNTASGAT 1660
               ...:|.::..:.|.|..|.|.|..:|||:.|....|||.||:.|.:|..|...|..
 Worm   952 ---VACIKSLRLQINSNWSELIGMSENECVRVILQVLGKWPLFGSDLHEASMRTDNERK------ 1007

  Fly  1661 PVAWLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFMLVV-------SHDDGGGGEQKLL 1718
              .:||:.:.::::|:......:...||||:.|||..|.||||.:       ||.| ...:::|.
 Worm  1008 --IYLALNDHSVSLLDRRHFDVIRTIPYSSLSTFGQFQQDFMLTIIRPLTPGSHPD-EAPKERLT 1069

  Fly  1719 FAMSKPKILEITLLIADYM 1737
            |:|.|.:|.::||.:|:|:
 Worm  1070 FSMQKNEIEQLTLHLAEYI 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43867	NP_001284762.1	TPH	395..>462	CDD:464007	18/47 (38%)
		PH1_PLEKHH1_PLEKHH2	944..1039	CDD:241436	22/99 (22%)
		PH	1050..1151	CDD:214574	30/108 (28%)
		MyTH4	1191..1410	CDD:214535	65/224 (29%)
		FERM_F1_Max1_like	1420..1520	CDD:340614	39/100 (39%)
		B41	1423..1643	CDD:214604	80/222 (36%)
		PH-like	1639..1741	CDD:473070	32/106 (30%)
max-1	NP_001367137.1	PH	353..450	CDD:214574	23/97 (24%)
		PH	468..579	CDD:214574	31/110 (28%)
		MyTH4	662..766	CDD:459939	50/170 (29%)
		B41	781..996	CDD:214604	80/222 (36%)
		PH-like	992..1088	CDD:473070	31/104 (30%)