DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43867 and plekhh2

DIOPT Version :9

Sequence 1:NP_001284762.1 Gene:CG43867 / 31031 FlyBaseID:FBgn0264449 Length:1852 Species:Drosophila melanogaster
Sequence 2:XP_002932439.1 Gene:plekhh2 / 100485060 XenbaseID:XB-GENE-6042215 Length:1466 Species:Xenopus tropicalis


Alignment Length:1720 Identity:575/1720 - (33%)
Similarity:816/1720 - (47%) Gaps:492/1720 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 INWQERCLELQLELHRSKNQAGRIRDMLREKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPK 340
            |:|:|||:.|:.:|.:.:.||.|||::|.||:.:||::|.||..|||:|.::|:.||::|.    
 Frog    11 IDWEERCMTLESQLMKFRIQANRIRELLAEKMQQLERQVTEANRRAEKAYEQVQVMEEKLK---- 71

  Fly   341 PPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLE 405
                               .::.|..:|:...   :|.|.....        ..||.:..|..||
 Frog    72 -------------------AANIQTSEAETRW---YQKSQDLEV--------LVQEKDDIIRCLE 106

  Fly   406 IQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKNHIANQSQ 470
            .::|:|:|:|:.:|:.||.||||||:||.:|||:||.:||.||..|...|:::..|::.:.....
 Frog   107 QELEDQKQIRIQEAKMIEDKAAKIKDWVTSKLRELELENQNLRLTNKNYNEEITSLRSKLQEIKD 171

  Fly   471 RHSIVGPVRNS------LSLDVQDFTGSGSNPEHRRRSESLDP-QEIIGRPLTS----SYPHHQH 524
            :.|.||..:..      .||....|       ::|.:|..:|| :|...:.||.    ||.::..
 Frog   172 KKSSVGATQKPSEGQRLSSLTFGCF-------QNRAKSPQVDPKREENSKSLTEATDCSYENNMK 229

  Fly   525 RRNLSMEPQEL---ERNLVAAVDGLTLAPLSSIS---------------NKAPGGVP----TESG 567
            .:..|::.|::   :.:|.....|...|.:.|||               |.....||    :|.|
 Frog   230 EKAPSIQWQDISDAQASLSRCSKGRVCAEIPSISISDWSSEEDIKKPQANARSVSVPSSQISEEG 294

  Fly   568 VVTRPDSSDT--------------------DTAHDYAEIYT------------------------ 588
            .......||.                    :..:|.|.:|:                        
 Frog   295 KWNSRSGSDLYLTVSEDSNSACEEEGVELHNNNNDQAVLYSMQRGLQRSPQHVFNGKKYFTFSNQ 359

  Fly   589 -----PSCEKL-------------------PAW-MKNNPALMASGGNSSTTTTTTSELGVP---- 624
                 .|.|:|                   |.: .||..:....||..||...:.:.|..|    
 Frog   360 RAKLEKSTEELNNKYSFPGLDYTLFSSDTSPTFSSKNVNSTPRPGGQHSTPKDSATNLPSPKQRT 424

  Fly   625 ----------------------------------------------------------------- 624
                                                                             
 Frog   425 PNILSMSEASAKKHLSQPQMSSDRMFGKNRNAISMVKPYRPQETDIDLIDEQSSMFQKMDTSYDG 489

  Fly   625 ----------------------------RPPTPPLHRFPSWEAKIYQVANDGLAGAGTGTSTAES 661
                                        :|||||||||||||.:||.:|..|:         ..|
 Frog   490 ISFSYDTRDGQNSVDKGTVGFPEKAHCAKPPTPPLHRFPSWENRIYSIAKSGM---------RMS 545

  Fly   662 TASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDGHGTLGSTPGTPLPPSRQQQTASGGFCDI 726
            ..|.||:.:..:.|:.|.           :|:.|                        |..:.::
 Frog   546 DVSSEPNNKGNLITSAST-----------SGVYT------------------------SLIYKNL 575

  Fly   727 SVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHAVMLTHHSHNSSSTDNTETSTSGSASSPSKS 791
            :.|||.|:||:|:||.:.|.     :|||..|:.     ..|.:||.|..::......|.|| ::
 Frog   576 TTPVYTTLKGKATQISTSPL-----EDSSGSEEE-----DSSRSSSRTSESDCRNQSDAGSP-RA 629

  Fly   792 LKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTPSSRINQHLQPSQHQHHTLSNQNHGHQLGAY 856
            ||                                                               
 Frog   630 LK--------------------------------------------------------------- 631

  Fly   857 TVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTVISDLSFESGLSD-DYALPPDAVSESTCMDA 920
                                           ||     :||.|..|| |||:||||.|..:  :.
 Frog   632 -------------------------------RG-----ISFSSMTSDSDYAIPPDAYSIDS--EF 658

  Fly   921 SMPSLLMRQSYVDS-PSKKIESLEKMGHLAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRKPQ 984
            |.|...:.::...| .:.|.|.|||.|:|.|:|||:|||::||||||.|.|.|:||..||.||||
 Frog   659 SEPEQKLPKTCSSSNDNGKNELLEKSGYLLKMGGKIKTWKRRWFVLKGGELLYYKSPSDVIRKPQ 723

  Fly   985 GQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSHATMDDWIRVLQNVQRRNATKLLLSRDDQK 1049
            |||:|:....|.:.:|..|.::.|.|:.|||||||...:|:|:||||:|.:..|..:|.::.|.|
 Frog   724 GQIELNSSSHILKGDGKQTVQLVTEKRTYYLTADSPNILDEWVRVLQSVLKVQAASVLFTQPDVK 788

  Fly  1050 PTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAETNPLGQINMRDARVEEVEHVSDSDSE-ERE 1113
            |||:|.:||||:|:.|:.||.|:||...||::..|..|||||.:.:|:||||:...|||.: |..
 Frog   789 PTVKGLLTKVKHGYSKRVWCTLVGKTLYYFRSQEEKFPLGQIKLWEAKVEEVDRSCDSDEDYETN 853

  Fly  1114 DAAQDQARLTVAIYPAHQGPTYLILSGKPERDNWLYHLTVVSG-GGPSAGTQYEQLVQKLMETDG 1177
            ..:......|:.|:|..|.||||::..|.|::.|.||||:.:| .|.:.||::||||.||:.::|
 Frog   854 GRSLLSTHYTIVIHPKEQDPTYLLIGSKHEKETWHYHLTMAAGITGVNVGTEFEQLVCKLLSSEG 918

  Fly  1178 DPNCVLWRHPILLHTKDTITAPLSSMHTETMQPEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNA 1242
            :|...:||||:|.|:|:.||:.|:::.:|.:|.|||||||:.|||::.||:.|.|||||.|||:|
 Frog   919 EPCTQIWRHPVLCHSKEAITSALTTLPSEALQTEAIKLFKTCQLFLNAAVDSPAIDYHVSLAQSA 983

  Fly  1243 LQHALDMPELQTEMICILIKQTSRHLGQKLSVGVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGH 1307
            ||..|..||||.||.|.|||||.                                         |
 Frog   984 LQVCLTHPELQNEMYCQLIKQTR-----------------------------------------H 1007

  Fly  1308 AQANGSSPTSIQAPSATPIIDCKSNPPVYSFVQGWQLLALAVSLFVPRSSRLLWYLKLHLSRNAD 1372
            .|.|.         .|:||             ||||||||...||:|:.. .:|.|||:||:|||
 Frog  1008 RQPNN---------QASPI-------------QGWQLLALCTGLFLPQHP-YIWLLKLYLSKNAD 1049

  Fly  1373 TKTETGKYAAYCERALERTLKNGGRETKPSRMEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSF 1437
            .:||.||||.||:|.:|||.:||.|:.||||||:|||||:||||||||.:||||.||.|||||.|
 Frog  1050 NRTEAGKYAIYCQRCVERTQQNGDRQAKPSRMEILSILLRNPYHHSLPFSIPVHFMNGTYQVVGF 1114

  Fly  1438 DGSTTIEEFQATLAHELGTR-DATNGFCLFSDDPIEKDLEHYLEPLAKLCDVISKWETALREKGS 1501
            |.|||:|||..||..::|.| ...:||.||:|||..|..||.|:...|:||:|||||.|.:|:..
 Frog  1115 DASTTVEEFLCTLNQDIGMRKPGLSGFALFTDDPSGKHFEHCLQGNLKICDIISKWEQASKEQHP 1179

  Fly  1502 GKFENSRVIQLSYKNRLYWKHTIKCETDKERLLLCYQTNSQIVQGRFPLSRELALELASLMSQID 1566
            ||.:.||.::|:|||||.:....:.||:||:|||.||||.:||.|.||:::|||||||:|::|::
 Frog  1180 GKCDGSRTVRLTYKNRLCFSAQTRGETEKEKLLLMYQTNDKIVNGMFPVNKELALELAALLAQVE 1244

  Fly  1567 MGDY------SLEKSRDVGVGLKGLDKFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCV 1625
            .||:      :|.:.:......:.|:||||.||:|....||||.:|:.|.::|:.|:|.|..|||
 Frog  1245 SGDFERPSQTALCQGKSSQAVKQALEKFYPKRYKDDCSEEQLKQLQQRLATRWIALRGHSGSDCV 1309

  Fly  1626 RIYLTCCRKWPYFGACLFQAKP-RQSPESNTASGATPVAWLAVAEDALNVLELSTMAPVARYPYS 1689
            |||||..|||..||..||.||| ..:|..|.      :.||||.||.::|||.:||..:..|.:.
 Frog  1310 RIYLTVARKWALFGGTLFAAKPILPTPFENA------IVWLAVHEDGISVLEYNTMRLLFTYAHR 1368

  Fly  1690 SVMTFGGCQDDFMLVVSHD-DGGGGEQKLLFAMSKPKILEITLLIADYMNALGHTVPGTPQ---- 1749
            |:|||||.:|||||||::. ......:||||||:||||||:|||||.|:|.. |....|..    
 Frog  1369 SLMTFGGHRDDFMLVVNNTLTKDKPSEKLLFAMAKPKILEMTLLIASYINVY-HQQKVTAHHLSA 1432

  Fly  1750 --------MNSLTRNGSHRSLRTSQRPNLG 1771
                    |.|..:....:.|.:|.||..|
 Frog  1433 PALLSAQVMESKGKQMGSQPLLSSNRPTKG 1462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43867NP_001284762.1 PH 942..1035 CDD:278594 52/92 (57%)
PH1_PLEKHH1_PLEKHH2 944..1039 CDD:241436 50/94 (53%)
PH 1050..1151 CDD:214574 44/101 (44%)
PH 1053..1151 CDD:278594 41/98 (42%)
MyTH4 1191..1410 CDD:214535 93/218 (43%)
B41 1423..1643 CDD:214604 113/226 (50%)
FERM_M 1527..1643 CDD:278785 59/121 (49%)
PH-like 1639..1741 CDD:302622 52/103 (50%)
plekhh2XP_002932439.1 SMC_prok_B <14..>172 CDD:274008 62/191 (32%)
PH1_PLEKHH1_PLEKHH2 683..778 CDD:241436 50/94 (53%)
PH 789..895 CDD:214574 47/105 (45%)
MyTH4 932..1087 CDD:214535 93/218 (43%)
FERM_F1_PLEKHH2 1097..1199 CDD:340699 55/101 (54%)
B41 1100..1327 CDD:214604 113/226 (50%)
FERM_C-lobe_PLEKHH1_PLEKHH2 1323..1422 CDD:241360 52/105 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 143 1.000 Domainoid score I4636
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 883 1.000 Inparanoid score I392
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48143at33208
OrthoFinder 1 1.000 - - FOG0004352
OrthoInspector 1 1.000 - - oto102446
Panther 1 1.100 - - O PTHR22903
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3701
SonicParanoid 1 1.000 - - X3070
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
99.190

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