DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec22 and SEC22C

DIOPT Version :9

Sequence 1:	NP_001259103.1	Gene:	Sec22 / 31030	FlyBaseID:	FBgn0260855	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_116752.1	Gene:	SEC22C / 9117	HGNCID:	16828	Length:	303	Species:	Homo sapiens

Alignment Length:	172	Identity:	51/172 - (29%)
Similarity:	74/172 - (43%)	Gaps:	24/172 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IARVIDGLPLVGT-----MQDDEQVPSGRSILDYQNQAKMLFRKLGTHSPARCSIETGPYLFHYL 66
            :.||.|||||..:     .||         .|:::.:.|.|..:|..: |.|.|.|...:..|:.
Human     9 VVRVRDGLPLSASTDFYHTQD---------FLEWRRRLKSLALRLAQY-PGRGSAEGCDFSIHFS 63

  Fly    67 IENDVCYLVMVDKMYSKRLAFNYLEDLAQEFHANYGRR-VNSVTRPYAFIEFDVYIQKAKKQLTD 130
            ...||..:.:........:||.:||.|..||.|:|... :...:|||||:|||..|||.|...
Human    64 SFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTCIGLASRPYAFLEFDSIIQKVKWHF-- 126

  Fly   131 RRRNISNINTQLQDVQRIMVQNIDDVLQRGTVLAELDTKTQN 172
            ...:.|.:...|:.:|..:      .||...||...||...|
Human   127 NYVSSSQMECSLEKIQEEL------KLQPPAVLTLEDTDVAN 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec22	NP_001259103.1	SNC1	10..192	CDD:227472	50/169 (30%)
		Longin	39..105	CDD:290490	19/66 (29%)
		R-SNARE_SEC22	132..195	CDD:277219	10/41 (24%)
SEC22C	NP_116752.1	Longin	42..114	CDD:316307	22/72 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D903466at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820