DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec22 and Sec22b

DIOPT Version :9

Sequence 1:	NP_001259103.1	Gene:	Sec22 / 31030	FlyBaseID:	FBgn0260855	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_035472.1	Gene:	Sec22b / 20333	MGIID:	1338759	Length:	215	Species:	Mus musculus

Alignment Length:	217	Identity:	122/217 - (56%)
Similarity:	157/217 - (72%)	Gaps:	6/217 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALLTMIARVIDGLPLVGTMQDDEQVPSGRSILDYQNQAKMLFRKLGTHSPARCSIETGPYLFHY 65
            |.||||||||.|||||..:||:|||  |||.:..||:|||.|||||...||.||::|.|...|||
Mouse     1 MVLLTMIARVADGLPLAASMQEDEQ--SGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMTFHY 63

  Fly    66 LIENDVCYLVMVDKMYSKRLAFNYLEDLAQEFHANYGRRVNSVTRPYAFIEFDVYIQKAKKQLTD 130
            :||..|||||:.:..:.|:|||.|||||..||...:|::|.:|:|||:|||||.:|||.||...|
Mouse    64 IIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTFIQKTKKLYID 128

  Fly   131 --RRRNISNINTQLQDVQRIMVQNIDDVLQRGTVLAELDTKTQNLSMMSQKYKKDAKLLNRKSMY 193
              .|||:.:|||:|||||||||.||::|||||..|:.||:|..|||.:|:||::|||.||.:|.|
Mouse   129 SRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRSTY 193

  Fly   194 VKAMALGMILLVFIMY--FWVL 213
            .|..|:.:..::.|:|  ||.|
Mouse   194 AKLAAVAVFFIMLIVYVRFWWL 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec22	NP_001259103.1	SNC1	10..192	CDD:227472	105/183 (57%)
		Longin	39..105	CDD:290490	35/65 (54%)
		R-SNARE_SEC22	132..195	CDD:277219	39/62 (63%)
Sec22b	NP_035472.1	Longin	3..126	CDD:341428	74/124 (60%)
Sec22b	NP_035472.1	R-SNARE_SEC22	132..195	CDD:277219	39/62 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850042
Domainoid	1	1.000	101	1.000	Domainoid score	I6955
eggNOG	1	0.900	-	-		E1_COG5143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3597
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3339
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53513
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004133
OrthoInspector	1	1.000	-	-		oto92278
orthoMCL	1	0.900	-	-		OOG6_101898
Panther	1	1.100	-	-	LDO	PTHR45837
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6269
SonicParanoid	1	1.000	-	-		X3400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790