DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec22 and sec-22

DIOPT Version :9

Sequence 1:	NP_001259103.1	Gene:	Sec22 / 31030	FlyBaseID:	FBgn0260855	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_508198.1	Gene:	sec-22 / 180456	WormBaseID:	WBGene00018853	Length:	214	Species:	Caenorhabditis elegans

Alignment Length:	207	Identity:	93/207 - (44%)
Similarity:	140/207 - (67%)	Gaps:	3/207 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTMIARVIDGLPLVGTMQDDEQVPSGRSILDYQNQAKMLFRKLGTHSPARCSIETGPYLFHYLIE 68
            ||:||||.|||.|..:::.:.......|::.|.|||||||:|| ..:||:.|:|:||::|||:|.
Worm     3 LTLIARVRDGLILATSIEGNNDGSGDSSMVKYSNQAKMLFKKL-NGAPAQQSVESGPFVFHYIIV 66

  Fly    69 NDVCYLVMVDKMYSKRLAFNYLEDLAQEFHANYGRRVNSVTRPYAFIEFDVYIQKAKKQLTDRRR 133
            .::|.||:.|:.:.:::||.||.|:.|||......|:..|.|||.|:|||.|||:||::..|..:
Worm    67 QNICALVLCDRNFPRKVAFQYLSDIGQEFLNENSSRIEQVVRPYHFLEFDKYIQQAKQRYGDTNK 131

  Fly   134 NISN-INTQLQDVQRIMVQNIDDVLQRGTVLAELDTKTQNLSMMSQKYKKDAKLLNRKSMYVK-A 196
            :..| ::.:||||.||||.||:||:.||..|..|:.:...||.||:||:.|||.|||:|...| |
Worm   132 HAMNTVSNELQDVTRIMVTNIEDVIHRGEALNILENRASELSGMSKKYRDDAKALNRRSTIFKVA 196

  Fly   197 MALGMILLVFIM 208
            .::|:..::|:|
Worm   197 ASIGIAGVLFLM 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec22	NP_001259103.1	SNC1	10..192	CDD:227472	82/182 (45%)
		Longin	39..105	CDD:290490	29/65 (45%)
		R-SNARE_SEC22	132..195	CDD:277219	30/63 (48%)
sec-22	NP_508198.1	Longin	38..103	CDD:290490	29/65 (45%)
		R-SNARE_SEC22	131..194	CDD:277219	30/62 (48%)
		Synaptobrevin	134..214	CDD:279324	35/75 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167213
Domainoid	1	1.000	86	1.000	Domainoid score	I5198
eggNOG	1	0.900	-	-		E1_COG5143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3597
Inparanoid	1	1.050	179	1.000	Inparanoid score	I2679
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53513
OrthoDB	1	1.010	-	-		D569556at33208
OrthoFinder	1	1.000	-	-		FOG0004133
OrthoInspector	1	1.000	-	-		oto19484
orthoMCL	1	0.900	-	-		OOG6_101898
Panther	1	1.100	-	-	LDO	PTHR45837
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6269
SonicParanoid	1	1.000	-	-		X3400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840