DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf and RBR1

DIOPT Version :9

Sequence 1:	NP_525036.2	Gene:	Rbf / 31027	FlyBaseID:	FBgn0015799	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_566417.3	Gene:	RBR1 / 820408	AraportID:	AT3G12280	Length:	1013	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	224/998 - (22%)
Similarity:	373/998 - (37%)	Gaps:	274/998 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 AEYTNLC-RDLNMDRQTELQGYETYLEVSQ--RCSMEGTAS--------HWMCCAIYTACRRTST 83
            |...::| :.|::|..|..:..:.:.|..:  ..||....|        .|....:|:..|.:..
plant    21 ASLLDICEKVLSLDGSTCDEALKLFTETKRILSASMSNIGSGTREEVERFWFAFILYSVKRLSVR 85

  Fly    84 PTVTGQNAVVKG-NCVSLNNLLRCCKMSIYEFKTKIKQW-------------CDMANLPQEFVNE 134
            ....|.:  |.| |..:|..:||..|::|.:|..::.|:             .|..|..|  ..|
plant    86 KEADGLS--VSGDNEFNLCQILRALKLNIVDFFKELPQFVVKAGSVLGELYGADWENRLQ--AKE 146

  Fly   135 IEDLDRKFSITFMLHKR-FRIIMDMIFSCPPNEKKHSKYISLHGNHAHGKCSYIKLDD--ICWRL 196
            ::......|:....:|| ||   :...:...|.:|:|...|          :|: ||.  ..|.|
plant   147 VQANFVHLSLLSKYYKRGFR---EFFLTYDANAEKNSANSS----------TYL-LDSYRFGWLL 197

  Fly   197 FLCAKNQKPSNTVDLVTSYNLMICCIDLIYNNVLAEKRTDLINPKFEGLPSNWTELDFRHNPHCI 261
            ||..:|...|...||||..|.::..:.::..:|....|...|......:......:|       :
plant   198 FLALRNHAFSRFKDLVTCSNGVVSILAILIIHVPCRFRNFSIQDSSRFVKKGDKGVD-------L 255

  Fly   262 LSNFC---DMTEE--------AKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENF--ERNL 313
            :::.|   |.:|:        |..:..|..::..|...:..|...:.....||...|:.  |.::
plant   256 VASLCKIYDASEDELRIVIDKANNLVETILKKKPSPASECQTDKLDNIDPDGLTYFEDLLEETSI 320

  Fly   314 KSLNISYEQ-YVLSVGEFDERILSAYDAGEHTALNDQSLRP---PVTPLTRKQDLPAQPA----- 369
            .:..|:.|: |....||.|||:   :...|.:.|...||..   .:|.:.||.|..:.||
plant   321 STSLITLEKDYYDGKGELDERV---FINEEDSLLGSGSLSAGAVNITGVKRKIDALSSPARTFIS 382

  Fly   370 --------------MAGD---KFEPVRNATNNVKQLSAFGRITEP---------TDFVKQAGEEV 408
                          ::|.   ...||..|....|.|..   :..|         ..|:|....::
plant   383 PLSPHKSPAAKTNGISGATKLAATPVSTAMTTAKWLRT---VISPLLPKPSPGLEHFLKSCDRDI 444

  Fly   409 ---IAKLLSIIEEIEQKFLAKYPSTE--------------------AKSRFQLAKSFFFYLLDQI 450
               :.:...||.|      |.:|::.                    |:.|...|...::.:|:.:
plant   445 TNDVTRRAHIILE------AIFPNSSLGAQCGGGSLQAVDLMDDIWAEQRRLEACKLYYRVLEAM 503

  Fly   451 LQAEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKT-ELKFPWVLDCFSISAFEFQK 514
            .:||.:.....:|..||..:    .|:..::||..||||..:|| .:.||.||:...|:||:..|
plant   504 CKAEAQILHANNLNSLLTNE----RFHRCMLACSAELVLATHKTITMLFPAVLERTGITAFDLSK 564

  Fly   515 IIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTVWEMIASA---------QLPLPTW 570
            :||..:|   ||..|.|.|.:||||:||..||.:.|.:.|:::..:..|         ||.|...
plant   565 VIESFIR---HEDSLPRELRRHLNSLEERLLESMVWEKGSSMYNSLIVARPSLALEINQLGLLAE 626

  Fly   571 LMVNLDRAAG------------------------------------------------------- 580
            .|.:||..|.
plant   627 PMPSLDAIAALINFSDGANHASSVQKHETCPGQNGGIRSPKRLCTDYRSILVERNSFTSPVKDRL 691

  Fly   581 -------------PLQ------------------------IFLRKVYLLGWLRIQKLCSELSLCE 608
                         |||                        ||..|:..|..:||..:...|.|.:
plant   692 LALGNVKSKMLPPPLQSAFASPTRPNPGGGGETCAETGINIFFTKINKLAAVRINGMVERLQLSQ 756

  Fly   609 KTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSV 673
            :..||::..|:|.:...|.|:..||:||.|:|..|...::.:| ...|.:|:..||.|||....|
plant   757 QIRESVYCFFQHVLAQRTSLLFSRHIDQIILCCFYGVAKISQM-SLTFREIIYNYRKQPQCKPLV 820

  Fly   674 YREVFID---INEDGE--PKVKDIIHFYNHTYVPLMRQFVIDYLNVTPDVSGRASDL-------- 725
            :|.|::|   ....|.  |...|||.|||..::|.::..:::...|..|.:..|::.
plant   821 FRSVYVDALQCRRQGRIGPDHVDIITFYNEIFIPAVKPLLVELGPVRNDRAVEANNKPEGQCPGS 885

  Fly   726 -QLSPHPKERAAQPKKVTQSHSLFVSQM--SKNEIQQSPNQMVYSFC--------RSPAKDLQAM 779
             ::|..|......||||:..|:::||.:  ||.:...|.:...|..|        :||:|||.|:
plant   886 PKVSVFPSVPDMSPKKVSAVHNVYVSPLRGSKMDALISHSTKSYYACVGESTHAYQSPSKDLSAI 950

  Fly   780 NEKVRGG----KRMLSFGDEPGL 798
            |.::...    ||.|:|..|.|:
plant   951 NNRLNNSSSNRKRTLNFDAEAGM 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..225	CDD:288762	37/151 (25%)
		RB_A	376..560	CDD:280101	57/216 (26%)
		RB_B	582..704	CDD:280100	44/150 (29%)
RBR1	NP_566417.3	DUF3452	92..226	CDD:371807	37/151 (25%)
		RB_A	406..607	CDD:366846	57/216 (26%)
		RB_B	729..857	CDD:366845	42/128 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I3152
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1784
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	1	1.000	-	-		otm2953
orthoMCL	1	0.900	-	-		OOG6_103769
Panther	1	1.100	-	-	LDO	PTHR13742
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830