DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf and rbl1

DIOPT Version :9

Sequence 1:	NP_525036.2	Gene:	Rbf / 31027	FlyBaseID:	FBgn0015799	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001124082.1	Gene:	rbl1 / 795522	ZFINID:	ZDB-GENE-030131-8179	Length:	1058	Species:	Danio rerio

Alignment Length:	1061	Identity:	301/1061 - (28%)
Similarity:	464/1061 - (43%)	Gaps:	310/1061 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GAEVVSGLVATSDDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAI 74
            |.|..:..|.::|.   .|.:.:..||::||||.:|..:..:.:..:....::||...||:.|::
Zfish     3 GDETDTESVRSADG---SIRSNFEALCQELNMDEETAAEALQNFRSIWNTYTLEGDVMHWLACSL 64

  Fly    75 YTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQEFVNEIEDLD 139
            |.|||::|.|||  ...|::||||||..:||..|:|:.:|.:|:|:|.|||||.|:|.:.|..|:
Zfish    65 YAACRKSSIPTV--GRGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWSDMANLCQDFRSRIGRLE 127

  Fly   140 RKFSITFMLHKRFR-IIMDMIFSCP-------PNEKKHSKYISLHGNHAHGKCSYIKLDDICWRL 196
            |.|.::.::.::|. |.:|| |..|       |..:||.:.          .|....:...||.|
Zfish   128 RNFEVSTVIFRKFEPIFLDM-FQNPQSEPPRMPRSRKHRRL----------PCHISDVFKFCWTL 181

  Fly   197 FLCAKNQKPSNTVDLVTSYNLMICCIDLIY-NNVLAEKRTDLINPKFEGLPSNWTELDFRHNPHC 260
            |:..|........|||.||:|::||:||:: |.::...|.||||..|.|||.: || :.:..| |
Zfish   182 FVYTKGNFHMIGDDLVNSYHLLLCCLDLVFCNALMCSNRKDLINQNFRGLPKD-TE-NLKEMP-C 243

  Fly   261 ILSNFCDMTE----EAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYE 321
            ::...|::.:    |||.:|...|:..:.:.|:...:.|:.:|:..||...||:.|.|::|..||
Zfish   244 VIDKLCELHDGLVVEAKGIKEHYFKPYIKTLFEKRMLKGDVETLTELLDTPNFQDNNKAINRDYE 308

  Fly   322 QYVLSVGEFDERILSAYDAGE---------------HTALNDQ-------------SLRPPVTPL 358
            ::||:||:||||:....||.|               |.:...|             ||.|. |||
Zfish   309 EFVLTVGDFDERVFLGADADEEIGTPRKSPAEPPSGHLSARMQVENNLQQHFEKTRSLAPS-TPL 372

  Fly   359 TRKQDLPAQPAMAGDKFEPVRNATNNVKQLSAF--GRITEPTDFVKQ----AGEEVIAKLLSIIE 417
            |.::.|..:..:.    .||.:||.:|.:|.:.  |....|:|.:.|    ........:|:.::
Zfish   373 TGRRYLKEKEVLV----TPVSSATQSVSRLQSMVSGLRNAPSDALLQIFNSCSRNPTESILNRVK 433

  Fly   418 EIEQKFLAKY--PSTE--------AKSRFQLAKSFFFYLLDQILQAEIRNKPDIDLKRLLVQKVS 472
            .:.:||...|  |:.:        |:.|.:||:..:|.:|:.::..|::.....|...||.|:|
Zfish   434 TLGEKFKQAYTNPTDDLPGAHMDFAEKRLKLAEILYFKILENVMTQEMKRLQGKDWAVLLEQEV- 497

  Fly   473 LVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHL 537
               .:.:|:|||:|:||.:|.::..|||:|:.|.|..|.|.|:||:.:|  |.|| |:|.::|||
Zfish   498 ---LHCSLLACCLEVVLFSYSSQRTFPWILEIFQIPPFYFYKVIEVFIR--SEEG-LSRDMVKHL 556

  Fly   538 NSIEETCLERLAWARNSTVWEMI------------------------------------------ 560
            |||||..||..||.|:|.:|..:
Zfish   557 NSIEEQVLESRAWTRDSALWNALNKDNNKVPTVEEVNFPSNFDTGNNAGGPTHLPLVALSPIIHP 621

  Fly   561 ----------ASAQ--------------------------------------------------- 564
                      :||:
Zfish   622 RLREVRTGLGSSARKDVPQSPISLHDRYSSPAAGSAKRRLFGDDAPPQSPVKRISVTPIKIIPSG 686

  Fly   565 ----------------------LPLP---------TWLMV------------------------- 573
                                  :|||         |.:.:
Zfish   687 MENQTTTTTVLSMATGNGQQLTIPLPVVKNEAGGITVIQLQASDMNPLTAQVLLTASPSRPALAA 751

  Fly   574 ------------NLDRAAGPLQIFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHET 626
                        |..|..|.|.:|.||||.|..:|::.||.:|.:..:....||..||||:.|.|
Zfish   752 PAISSDSQPPPANKPRRTGSLALFFRKVYHLASVRLRDLCLKLDISSELRGKIWTCFEHSLLHCT 816

  Fly   627 ELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFI---------DIN 682
            :|||||||||.::||:||..|:.: |:..|.|||:.||.||||.:.|||.|.|         |.|
Zfish   817 DLMKDRHLDQLLLCAVYIISRITK-EEHTFQDIMKCYRTQPQANSHVYRSVLIKRRPKVQQADEN 880

  Fly   683 EDGEPKVK------------------------------DIIHFYNHTYVPLMRQFVIDYLNVTPD 717
            .:.:|...                              |:|.|||:.||..||.|...|...|.|
Zfish   881 MEVDPPADQSNERTDQAANERTDQADRTQTVFESEERGDLIQFYNNIYVSKMRSFAFKYALSTLD 945

  Fly   718 VSGRASDLQLSPHPKERA--AQPKKVTQSHSLFVSQMSKNEIQQSPN-QMVYSFCRSPAKDLQAM 779
              .|.....|||.|..|:  ..|::|:|.||:|||. .||....:|: ...|.|..||:|:|..:
Zfish   946 --NRMEAPPLSPFPSVRSHTLSPRRVSQKHSIFVSP-HKNSSSLTPSTAYTYRFTGSPSKELSDI 1007

  Fly   780 NEKVRGG----KRMLSF-GDE 795
            |:.:|.|    ||..:. |||
Zfish  1008 NQMIRQGGVSKKRAFTMEGDE 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..225	CDD:288762	50/142 (35%)
		RB_A	376..560	CDD:280101	67/199 (34%)
		RB_B	582..704	CDD:280100	59/160 (37%)
rbl1	NP_001124082.1	DUF3452	79..210	CDD:288762	50/141 (35%)
		RB_A	386..579	CDD:280101	67/199 (34%)
		RB_B	771..932	CDD:280100	59/161 (37%)
		Rb_C	951..>1041	CDD:286075	30/79 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580908
Domainoid	1	1.000	107	1.000	Domainoid score	I6448
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1539
OMA	1	1.010	-	-		QHG46367
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	1	1.000	-	-		otm25726
orthoMCL	1	0.900	-	-		OOG6_103769
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3203
SonicParanoid	1	1.000	-	-		X2053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800