DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbf and rb1

DIOPT Version :9

Sequence 1:	NP_525036.2	Gene:	Rbf / 31027	FlyBaseID:	FBgn0015799	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001071248.1	Gene:	rb1 / 777733	ZFINID:	ZDB-GENE-040428-1	Length:	903	Species:	Danio rerio

Alignment Length:	950	Identity:	203/950 - (21%)
Similarity:	377/950 - (39%)	Gaps:	273/950 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ELQGYETYLEVSQRC------SMEGT------ASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCV 98
            |||...:..:.:.|.      ||:.|      ...|..|..           :.|..  ::|..:
Zfish    51 ELQSTNSICDHAWRIWEREIRSMDKTNMPYSNRQQWGACLF-----------IAGME--LEGINL 102

  Fly    99 SLNNLLRCCKMSIYEFKTKIKQW-CDMANLPQEFVNEIEDLDRKFSITFMLHKRFRIIMDMIFSC 162
            :....|:...:|:.:|.:.:::. .::..:..:..:.:..|:.|:.:|..|::||....:.||:.
Zfish   103 TFTQFLKAVGLSVKQFISLVRKMDVNVDTISPKVNSAVTRLENKYDVTLALYQRFVKTCEKIFAE 167

  Fly   163 PPNEKKHSKYISLHGNHAHGKCSYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLI-- 225
            |.|.|:.                  :|.:..|.:||.||........|||.|:.|::|.::..
Zfish   168 PDNAKRK------------------ELWESSWTMFLLAKGTFLQMEDDLVISFQLLLCVLEFFAK 214

  Fly   226 ----------YNNVLAEK------RTDLINP-KFEGLPSNWTELDFRHNPHCILSNFCD----MT 269
                      ||:|::..      ||...|. |.:..|:   |:|.:     :|...|.    ..
Zfish   215 RLSPSLLQSPYNSVVSSSTLSPPTRTSRRNQGKSKPRPA---EMDMQ-----LLETLCKEGDCSV 271

  Fly   270 EEAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERI 334
            :|.|.:..:||...:.|              :|||..:... .:::|:..||:......:||.|:
Zfish   272 DEVKNVYQSTFCAFLDS--------------VGLLGLQGLP-PMEALSKQYEELYHKSKDFDARL 321

  Fly   335 LSAYDAGEHTALNDQSLRPPVTPLTRKQDLPAQPAMAGD-----KFEPVRNATNNVKQLSAFGRI 394
            ..:         :|::|.|....:::.:..|.:...|.|     ...|:|.|..:::||.  |.:
Zfish   322 FLS---------DDETLSPNKIEVSKVEVTPRKNLFAEDIAIPVPQTPIRAAMTSIQQLR--GDL 375

  Fly   395 TEPTD--------FVKQAGEEVIAKLLSIIEEIEQKFLAKYPSTE-------AKSRFQLAKSFFF 444
            |..:|        :.|....:...::...:||:.:.|:.::....       .:.||.|....::
Zfish   376 TSGSDQPSSNLLVYYKNCTVDPSGEIKKRVEELGEVFIQRFAQAVGQHCEGLGRKRFYLGAQLYY 440

  Fly   445 YLLDQILQAEIRNKPDIDLKRLLVQKVSLVI----FNITLMACCVELVLEAY------------- 492
            .:::.:|::|        .|||.||..|.::    |:.:|:||.:|:|:..|
Zfish   441 KVMESMLKSE--------EKRLSVQNFSKLLNNAAFHTSLLACALEVVIATYVGSSLKNGGFGRS 497

  Fly   493 -------KTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAW 550
                   :::|.|||:|..|.:.||:|.|:||..::   .|..|...::|||...|...:|.|||
Zfish   498 SGASDSVESDLCFPWILSVFQLPAFDFYKVIESFIK---AEPTLKHDMVKHLEQCEHVIMESLAW 559

  Fly   551 ARNSTVWEM--------------------------------------------IASAQLPLPTWL 571
            ..:|.::::                                            :..|:.|.|.
Zfish   560 RTDSPLFDLLKQSREEGPGEQAEPPATLNQPLHHNHTAADLYLSPVRPCRQPPVMEAEPPTPG-- 622

  Fly   572 MVNLDRA--AGPLQIFLRKVYLLGWLRIQKLCSELSLCEKTPES---IWHIFEHSITHETELMKD 631
                .||  :..|.:|.:|:|.:.:||::.|.|  :|....||.   ||.:.:|::.:|.|||:|
Zfish   623 ----TRAPRSNSLSLFYKKLYRMAYLRLKMLFS--NLLTSHPEMEPIIWTLLQHTLQNEYELMRD 681

  Fly   632 RHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFIDINEDGEPKVKDIIHFY 696
            |||||.||.|:|...:||.: |.:|..|:.||:..|......::.|.|     .|.:...||.||
Zfish   682 RHLDQLIMSAMYAICKVKNV-DLRFKTIVTAYKELPNTNQETFKRVLI-----REGQYDSIIVFY 740

  Fly   697 NHTYVPLMRQFVIDYLNVTPDVSGRASDLQLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQ--- 758
            |..::..::..::.|.:..|........:..||:..    .|.:|..|::::||.:..:.:.
Zfish   741 NLVFMQKLKTNILQYSSPRPPPLSPIPHIPCSPYKN----SPLRVPGSNNVYVSPLKSSRVSPLV 801

  Fly   759 ---------------------QSPNQMV----YSFCRS--------PAK----DLQAMNEKVRGG 786
                                 |..|||:    :|..||        |.|    |:...:| ..|.
Zfish   802 MTPRSRILISIGESFGSADKFQKINQMLSSSDWSLKRSLDGGSAPKPLKRLRFDMDGQDE-ADGS 865

  Fly   787 KRMLSFGDEPGLGTMAE--TKRSKISQVK----AVMDDPE 820
            |   |.|:...:..:||  :.||::.:.|    :..|.||
Zfish   866 K---SSGESALIQKLAEMSSTRSRMQEQKLKEESDKDHPE 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..225	CDD:288762	27/135 (20%)
		RB_A	376..560	CDD:280101	53/266 (20%)
		RB_B	582..704	CDD:280100	44/124 (35%)
rb1	NP_001071248.1	DUF3452	99..211	CDD:288762	27/129 (21%)
		RB_A	359..569	CDD:280101	53/222 (24%)
		RB_B	630..747	CDD:280100	44/124 (35%)
		Rb_C	752..899	CDD:286075	29/154 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580906
Domainoid	1	1.000	107	1.000	Domainoid score	I6448
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850