Protein Alignment Rbf and Rbl1

DIOPT Version :10

• Sequence 1: NP_525036.2
• Gene: Rbf / 31027
• FlyBaseID: FBgn0015799
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: NP_001177995.2
• Gene: Rbl1 / 680111
• RGDID: 1595511
• Length: 1063
• Species: Rattus norvegicus
• Alignment Length: 1097
• Identity: 306/1097 - (27%)
• Similarity: 473/1097 - (43%)
• Gaps: 340/1097 - (30%)

  Fly     1 MSEPDPQELGAEVVSGLVATSDDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGT 65
            |.|.:|...||    ..||.:.:.|:.       ||::||:|..:..:..:.:..:....|:||.
  Rat     1 MFEDEPHAEGA----AAVAAAREALQA-------LCQELNLDEGSAAEALDDFTAIRGNYSLEGE 54

  Fly    66 ASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQE 130
            ..||:.|::|.|||::..|||  ...|::||||||..:||..|:|:.:|.:|:|:|.||:|||||
  Rat    55 VIHWLACSLYVACRKSIIPTV--GKGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQE 117

  Fly   131 FVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCP-------PNEKKHSKYISLHGNHAHGKCSYIK 188
            |...||.|:|.|.::.::.|:|..|...||..|       |..:|..:.          .||...
  Rat   118 FRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEELPKLPRSRKQRRI----------PCSVKD 172

  Fly   189 LDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLIY-NNVLAEKRTDLINPKFEGLPSNWTEL 252
            |.:.||.||:..|........|||.||:|::||:|||: |.::...|.||:||.|:||||::..:
  Rat   173 LFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAV 237

  Fly   253 DFR--HNPHCILSNFCDMTE----EAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFER 311
            :|:  ..|.||::..||:.:    |||.:|...|:..:|..|....:.|  :.:|.|   .:|..
  Rat   238 NFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYISKLFDKKILKG--ECLLDL---SSFTD 297

  Fly   312 NLKSLNISYEQYVLSVGEFDERILSAYDAGEH------------------TALNDQSLR------ 352
            |.|::|..||:|||:||:|||||....||.|.                  .|..|.:|:
  Rat   298 NSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFAADTQFGKLTSQASVDCNLQQHFEKK 362

  Fly   353 ---PPVTPLTRKQDLPAQPAMAGDKFEPVRNATNNVKQLSAF--GRITEPTD----FVKQAGEEV 408
               .|.||||.::.|..:.|:.    .||.:||.:|.:|.:.  |..:.|::    ..:......
  Rat   363 RSFAPSTPLTGRRYLQEKEAVT----TPVASATQSVSRLQSIVAGLKSAPSEQLLTIFESCMRNP 423

  Fly   409 IAKLLSIIEEIEQKFLAKY-PSTE---------AKSRFQLAKSFFFYLLDQILQAEIRNKPDIDL 463
            :..::.|::.|.:.|...| .||:         |.:|.:||:..::.:|:.|:..|.|....:|:
  Rat   424 MGNIVKIVKGIGETFCQHYTQSTDKQPGSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDM 488

  Fly   464 KRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGC 528
            ..||.|.    ||:.:|:|||:|:||.||.:...|||::|...:..|.|.|:||:|:|  |.||
  Rat   489 SVLLEQD----IFHRSLLACCLEIVLFAYSSPRTFPWIIDVLGLQPFYFYKVIEVVIR--SEEG- 546

  Fly   529 LNRSLIKHLNSIEETCLERLAWARNSTVWEMI------------------------ASAQLPLPT 569
            |:|.::||||||||..||.|||..||.:||.:                        .|.|..||.
  Rat   547 LSRDMVKHLNSIEEQILESLAWTNNSALWEALRASANKVPSCEEVIFPNNFEIGNGGSVQGHLPM 611

  Fly   570 WLM-------------------------------------------------------------- 572
            ..|
  Rat   612 MPMSPIIHPRVKEVRTDSGSLRKDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKETLMEKIMA 676

  Fly   573 ----------------------------------------------------------------- 572
                                                                             
  Rat   677 EGTQLKIAPSSVTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNTT 741

  Fly   573 ------------------------------------VNLDRAAGPLQIFLRKVYLLGWLRIQKLC 601
                                                ::..:..|.|.:|.||||.|..:|::.||
  Rat   742 QDSTAESLVSLTAQSLIGASPKQTHLTKTQDAPLTGISKPKRTGSLALFYRKVYHLASVRLRDLC 806

  Fly   602 SELSLCEKTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQ 666
            .:|.:..:....||..||.::.|..:|||||||||.::||.||..:|.: |:..|.:||::||||
  Rat   807 LKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTK-EERTFQEIMKSYRNQ 870

  Fly   667 PQAVNSVYREVFI-------------------DI-------NEDGEPKVK----DIIHFYNHTYV 701
            |||.:.|||.|.:                   ||       |...|| ||    |:|.|||..||
  Rat   871 PQANSHVYRSVLLKSIPGEVVAYNGDYEMTDGDIEDATKTPNCSSEP-VKEERGDLIKFYNAIYV 934

  Fly   702 PLMRQFVIDYLNVTPDVSGR-----ASDLQLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQQSP 761
            ..::.|.:.|     |:|.:     |..|...||.|::...|::::|.||::||. .||....:|
  Rat   935 GRVKSFALKY-----DLSNQDHIMDAPPLSPFPHIKQQPGSPRRISQQHSIYVSP-HKNASGLTP 993

  Fly   762 -NQMVYSFCRSPAKDLQAMNEKVRGG-----KRMLSF-GDEPGLGTMAETKRSKISQ 811
             :.::|.|..||:|.|:.:|..:|.|     ||:::. ||       ||:...::.|
  Rat   994 RSALLYKFNGSPSKSLKDINNMIRQGEQKAKKRVIAISGD-------AESPAKRLCQ 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..228	CDD:463402	55/145 (38%)
		RB_A	377..560	CDD:460364	70/198 (35%)
		RB_B	582..705	CDD:460363	59/152 (39%)
Rbl1	NP_001177995.2	DUF3452	77..212	CDD:463402	55/144 (38%)
		Pocket, binds T and E1A. /evidence=ECO:0000250|UniProtKB:P28749	385..944		136/567 (24%)
		Domain A. /evidence=ECO:0000305	385..584		70/205 (34%)
		RB_A	385..578	CDD:460364	70/199 (35%)
		Spacer. /evidence=ECO:0000305	585..779		5/193 (3%)
		CYCLIN_RBL1	780..944	CDD:410308	61/165 (37%)
		Domain B. /evidence=ECO:0000305	780..944		61/165 (37%)
		Rb_C	956..>1041	CDD:462639	28/92 (30%)