DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf and RBL1

DIOPT Version :9

Sequence 1:	NP_525036.2	Gene:	Rbf / 31027	FlyBaseID:	FBgn0015799	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_024307724.1	Gene:	RBL1 / 5933	HGNCID:	9893	Length:	1105	Species:	Homo sapiens

Alignment Length:	1132	Identity:	301/1132 - (26%)
Similarity:	472/1132 - (41%)	Gaps:	368/1132 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEPDPQELGAEVVSGLVATSDDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGT 65
            |.|..|...||.|    ||.:.:.|:.       ||::||:|..:..:..:.:..:....|:||.
Human     1 MFEDKPHAEGAAV----VAAAGEALQA-------LCQELNLDEGSAAEALDDFTAIRGNYSLEGE 54

  Fly    66 ASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQE 130
            .:||:.|::|.|||::..|||  ...:::||||||..:||..|:|:.:|.:|:|:|.||:|||||
Human    55 VTHWLACSLYVACRKSIIPTV--GKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQE 117

  Fly   131 FVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCP-------PNEKKHSKYISLHGNHAHGKCSYIK 188
            |...||.|:|.|.::.::.|::..|...||..|       |..:|..:.          .||...
Human   118 FRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRI----------PCSVKD 172

  Fly   189 LDDICWRLFLCAKNQKPSNTV-------------------------------------DLVTSYN 216
            |.:.||.||:..|.:...:.|                                     |||.||:
Human   173 LFNFCWTLFVYTKGKMTLSVVLHFYSGNLVLFDMRGFWFLCLFFFFFPYKGNFRMIGDDLVNSYH 237

  Fly   217 LMICCIDLIY-NNVLAEKRTDLINPKFEGLPSNWTELDF--RHNPHCILSNFCDMTE----EAKA 274
            |::||:|||: |.::...|.||:||.|:||||::...||  ...|.||::..|::.:    |||.
Human   238 LLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKG 302

  Fly   275 MKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERILSAYD 339
            :|...|:..:|..|....:.|  :.:|.|   .:|..|.|::|..||:|||:||:|||||....|
Human   303 IKEHYFKPYISKLFDRKILKG--ECLLDL---SSFTDNSKAVNKEYEEYVLTVGDFDERIFLGAD 362

  Fly   340 AGEHTALNDQSLR---------------------------PPVTPLTRKQDLPAQPAMAGDKFEP 377
            |.|......:..|                           .|.||||.::.|..:.|:    ..|
Human   363 AEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAV----ITP 423

  Fly   378 VRNATNNVKQLSAF--GRITEPTD----FVKQAGEEVIAKLLSIIEEIEQKFLAKY-PSTE---- 431
            |.:||.:|.:|.:.  |....|:|    ..:......:..::.|::.|.:.|...| .||:
Human   424 VASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQPG 488

  Fly   432 -----AKSRFQLAKSFFFYLLDQILQAEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEA 491
                 |.:|.:||:..::.:|:.::..|.|....:|:..||.|.    ||:.:|||||:|:||.|
Human   489 SHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQD----IFHRSLMACCLEIVLFA 549

  Fly   492 YKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTV 556
            |.:...|||:::..::..|.|.|:||:|:|  |.|| |:|.::||||||||..||.|||:.:|.:
Human   550 YSSPRTFPWIIEVLNLQPFYFYKVIEVVIR--SEEG-LSRDMVKHLNSIEEQILESLAWSHDSAL 611

  Fly   557 WEMI--------------------------ASAQLPL---------------------------- 567
            ||.:                          ....|||
Human   612 WEALQVSANKVPTCEEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPL 676

  Fly   568 -----------PT----------------WLM--------------------------------- 572
                       ||                .||
Human   677 SPISVHERYSSPTAGSAKRRLFGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLT 741

  Fly   573 ----------------------------------------------------------------- 572

Human   742 MATAPVTGTTGHKVTIPLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLT 806

  Fly   573 ---------VNLDRAAGPLQIFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETEL 628
                     :|..:..|.|.:|.||||.|..:|::.||.:|.:..:....||..||.::.|..:|
Human   807 KAQEVHSTGINRPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDL 871

  Fly   629 MKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFI------------DI 681
            ||||||||.::||.||..:|.: |:..|.:||::|||||||.:.|||.|.:            :|
Human   872 MKDRHLDQLLLCAFYIMAKVTK-EERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNI 935

  Fly   682 NEDGE-----------------PKVK----DIIHFYNHTYVPLMRQFVIDYLNVTPDVSGRASDL 725
            |:|.|                 ..||    |:|.|||..||..::.|.:.|.....|....|..|
Human   936 NDDFEMIDCDLEDATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPL 1000

  Fly   726 QLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQQSP-NQMVYSFCRSPAKDLQAMNEKVRGG--- 786
            ...||.|::...|::::|.||:::|. .||....:| :.::|.|..||:|.|:.:|..:|.|
Human  1001 SPFPHIKQQPGSPRRISQQHSIYISP-HKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQR 1064

  Fly   787 --KRMLSFGDEPGLGTMAETKRSKISQ 811
              ||:::...:      ||:...::.|
Human  1065 TKKRVIAIDSD------AESPAKRVCQ 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..225	CDD:288762	52/178 (29%)
		RB_A	376..560	CDD:280101	69/199 (35%)
		RB_B	582..704	CDD:280100	58/154 (38%)
RBL1	XP_024307724.1	DUF3452	77..246	CDD:314758	52/178 (29%)
		RB_A	422..615	CDD:307805	69/199 (35%)
		RB_B	824..979	CDD:307804	58/155 (37%)
		Rb_C	998..>1083	CDD:312478	25/91 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147366
Domainoid	1	1.000	111	1.000	Domainoid score	I6234
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1622
Isobase	1	0.950	-	0	Normalized mean entropy	S7132
OMA	1	1.010	-	-		QHG46367
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	1	1.000	-	-		otm40415
orthoMCL	1	0.900	-	-		OOG6_103769
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3203
SonicParanoid	1	1.000	-	-		X2053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750