| Sequence 1: | NP_525036.2 | Gene: | Rbf / 31027 | FlyBaseID: | FBgn0015799 | Length: | 845 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000312.2 | Gene: | RB1 / 5925 | HGNCID: | 9884 | Length: | 928 | Species: | Homo sapiens |
| Alignment Length: | 173 | Identity: | 39/173 - (22%) |
|---|---|---|---|
| Similarity: | 56/173 - (32%) | Gaps: | 75/173 - (43%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 104 KLKSRPFLGEKSSFKLGEIPKPKEEKRREEPFTMRGFDFGSDDKV------------TKIRDKIC 156
Fly 157 DIVDPTNAR-RTDPN--------------FIRQMHENTLKGIEVASNPHFKKTRAPTKNRAAIQN 206
Fly 207 TLGT--LYPSF-----TTAAGQDPQNSK-----FQVPLDRQSS 237 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Rbf | NP_525036.2 | DUF3452 | 90..228 | CDD:463402 | 34/162 (21%) |
| RB_A | 377..560 | CDD:460364 | |||
| RB_B | 582..705 | CDD:460363 | |||
| RB1 | NP_000312.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..42 | ||
| DUF3452 | 114..227 | CDD:463402 | |||
| Pocket, binds T and E1A | 373..771 | 26/135 (19%) | |||
| Domain A | 373..579 | ||||
| RB_A | 373..573 | CDD:460364 | |||
| Spacer | 580..639 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 610..632 | ||||
| Domain B | 640..771 | 26/135 (19%) | |||
| CYCLIN_RB | 645..771 | CDD:410302 | 26/135 (19%) | ||
| Interaction with LIMD1. /evidence=ECO:0000269|PubMed:15542589 | 763..928 | 15/52 (29%) | |||
| Rb_C | 768..925 | CDD:462639 | 13/40 (33%) | ||
| Domain C, mediates interaction with E4F1. /evidence=ECO:0000269|PubMed:10869426 | 771..928 | 13/37 (35%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 860..928 | ||||
| Bipartite nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P13405 | 860..876 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||