Protein Alignment Rbf and lin-35

DIOPT Version :10

• Sequence 1: NP_525036.2
• Gene: Rbf / 31027
• FlyBaseID: FBgn0015799
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: NP_491686.1
• Gene: lin-35 / 172249
• WormBaseID: WBGene00003020
• Length: 961
• Species: Caenorhabditis elegans
• Alignment Length: 897
• Identity: 199/897 - (22%)
• Similarity: 350/897 - (39%)
• Gaps: 261/897 - (29%)

  Fly    36 CRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAIYTAC------RRTSTPTVTGQNAVVK 94
            ||..|:........:|||....||.|:||:.|.|...|||...      ||..|..:     :::
 Worm   137 CRAANLPNDIVTGAWETYNHAVQRVSLEGSESAWQLSAIYYYLLSKGIKRRGKTIRI-----LIQ 196

  Fly    95 GNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLP-----QEFVNEIEDLDRKFSITFMLHKRFRI 154
            ...||:..:.....:|:.|...|..::.::.:..     ||::..|::   ..:::.::.|:|..
 Worm   197 PFPVSILTIANSFDISVAEMLDKTARFVEIIHSRKIRRYQEYIRRIQE---GLAVSCVIFKKFCR 258

  Fly   155 IMDMIF--------SCPPNEKKHSKYISLHGNHAHGKCSYIKLDDICWRLFLCAKNQKPSNTV-D 210
            |...||        :||          |.|           :|..:.|..||..|::.   || |
 Worm   259 IFCKIFEEIKVGSENCP----------SSH-----------ELFTVLWTSFLVMKSRM---TVDD 299

  Fly   211 LVTSYNLMICCIDLIYNNVLAEKR--TDLINPKF-EGLPSN-------------WTELDFRHNPH 259
            |:::|.|:...:|.:|..:.:.|.  ...:|.|| |.|..|             .:.||.||
 Worm   300 LISNYQLLFSILDQVYTEMCSMKEGIVHHLNQKFVEDLLENDCTIIRALCTQFGGSVLDARH--- 361

  Fly   260 CILSNFCDMTEEAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFE--RNLKSLNI---S 319
                 |.|.|  .|.|:.|                       |:.:..||:  |:| .:|:   :
 Worm   362 -----FSDHT--FKKMEKT-----------------------GIPSTWNFQEFRDL-IMNVPKTA 395

  Fly   320 YEQYVLSVGEFDERIL--------------SAYDAGE----------------------HTALND 348
            ||.|:|..|..||||.              ..|...:                      :..|..
 Worm   396 YENYLLQRGSIDERIFIPSVEDFSKIFQSPDTYSVADILKVSYSGRRFRDAEFLTKISNNHCLEK 460

  Fly   349 QSLRPPVTP---LTRKQDLPAQPAMA--------GDKFEPVRNATNNVKQLSAFGRITEPTDFVK 402
            .:|...|..   :|:.::.|..|.:.        .|..|     :||   .|.:.|:|:.....|
 Worm   461 LALGGKVASEKLVTQSKEQPRVPCVEYNLELGNYPDDLE-----SNN---QSLYNRLTKIIGSWK 517

  Fly   403 QAG---EEV--------IAKLLSIIEEIEQKFLAKYPSTE---------AKSRFQLAKSF---FF 444
            ...   |||        :|.:|...:|:..|| .:..|.|         .|..:.:.|..   |.
 Worm   518 LENSKLEEVCGTMSDSPMATILLKSDEMTNKF-ERTLSAELGETINENIPKYHYNVRKELELVFL 581

  Fly   445 YLLDQILQAEIRNK-PDIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSIS 508
            ..:::|:.||::.| .:.||..::.::.    |..::...||||:|.:...:..|||..:...:.
 Worm   582 IFMEKIIVAELKKKVREEDLLNVIRREE----FLDSVFCFCVELILVSNGYDRPFPWSAELCGVH 642

  Fly   509 AFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTVWEMIA------------ 561
            .|.|.|:|::::   :||..|:|.:::|.:.||||.:|..:|..:|.:|.|:.
 Worm   643 PFMFHKVIDLMI---THEKQLSRQMVQHFSRIEETVIEYFSWKSDSPLWPMVVRCPFAHFQEFGE 704

  Fly   562 ------SAQLPL-------PTWLMVNLDRAAGP-------LQIFLRKVYLLGWLRIQKLCSELSL 606
                  ::..|:       |..|...|.|...|       |:|||::.|.....|:|.|...:|:
 Worm   705 DWADKLNSYSPIKFTPIKKPDDLRDELGRPIVPQNQTSRTLRIFLKRTYFTAARRLQDLTDRVSM 769

  Fly   607 CEKTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQ----- 666
            ..:.....|.:|::.:.::|.:..||||||.::|.:::.:::.. ....|::||..||.|
 Worm   770 GARAKSQCWSLFDYLLRNDTLIFMDRHLDQILLCCVFVIMKINE-SSMLFTEIMAQYRRQSANSL 833

  Fly   667 -----------------PQAVNSVYREVFIDINEDGEPKVK---DIIHFYNHTYVPLMRQFVIDY 711
                             |||||:  :|..:: ..:|..|.|   |||.:||..:...:: ::|..
 Worm   834 LVYRSVTVFQEQLNPENPQAVNT--KETILE-RLEGPQKEKTTVDIIKYYNIEFRDRIK-YIIGQ 894

  Fly   712 LNVTPDVSGRASDLQLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQQSPNQ 763
            ::...|     .||...|...|....|.:|..:|.|.:..:.|.:..:|..:
 Worm   895 IDSASD-----EDLMEMPVATESGLMPVRVYLTHKLSIQTLPKTKHGESKQE 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..228	CDD:463402	30/151 (20%)
		RB_A	377..560	CDD:460364	51/206 (25%)
		RB_B	582..705	CDD:460363	39/147 (27%)
lin-35	NP_491686.1	DUF3452	200..316	CDD:463402	29/142 (20%)
		PRK09248	<339..408	CDD:236429	22/102 (22%)
		RB_A	507..691	CDD:460364	48/191 (25%)
		RB_B	744..889	CDD:460363	39/148 (26%)