DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf and rbl2

DIOPT Version :9

Sequence 1:	NP_525036.2	Gene:	Rbf / 31027	FlyBaseID:	FBgn0015799	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_002937369.2	Gene:	rbl2 / 100490373	XenbaseID:	XB-GENE-1012835	Length:	1089	Species:	Xenopus tropicalis

Alignment Length:	1100	Identity:	277/1100 - (25%)
Similarity:	441/1100 - (40%)	Gaps:	337/1100 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAIYTACRRTSTPTVTGQN 90
            |.:...|..||..||||.:...:.:|.|..:||..::||.|.||:.|::|.|||:| .|||  ..
Frog    16 EQLRCRYDELCSSLNMDERARGEAWEYYSRISQNYTLEGNALHWLACSLYVACRQT-VPTV--GR 77

  Fly    91 AVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQEFVNEIEDLDRKFSITFMLHKRFRII 155
            ..|:||.|||..:|...::|:.||..|||:|.||||||.||....:.|:|.|:::.:|.|::..|
Frog    78 GTVEGNYVSLTQILSSSELSLIEFFNKIKKWEDMANLPTEFRTRTKKLERNFTVSAVLFKKYDPI 142

  Fly   156 MDMIFSCPPNEKKHSKYISLHGNHAHGK--CSYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLM 218
            ...:|..|..|:...     |......:  |:..::...||.||:..|...|..:.|||.||:|:
Frog   143 FQEVFRSPLEEQPRQ-----HRGRKQRRQPCTVSEVYQFCWVLFIHTKGNFPMISDDLVNSYHLL 202

  Fly   219 ICCIDLIYNNVL-AEKRTDLINPKFEGLPSNWTELDFRH--NPHCILSNFCDMTE----EAKAMK 276
            :|.:||:|.|.| ...|.:|:||.|:|||.::...:::.  ...||:...|.:.:    |||.:|
Frog   203 LCALDLVYGNALQCPNRRELLNPNFQGLPEDFCSREYKAPLEAPCIIETLCGLHDGLVLEAKGIK 267

  Fly   277 ATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERILSAYDAG 341
            ...::..:...|....:.|..|:::|.|...||..::|::|.:||.||||.|..|||:... |..
Frog   268 EHFWKPYIRKLFDKKILKGKSDSLVGFLDPGNFADSVKAINKAYEGYVLSAGNLDERVFME-DVE 331

  Fly   342 EHTALNDQSLRPPV---------TPLTRKQDLPAQPAMAGDKFEPVRNAT--NNVKQLSAFGRIT 395
            |......|.|.|.:         .....:|:.        |||:.:|.:|  .::|.:......|
Frog   332 EEIGRIGQCLNPSLGMESVERAKVTYNLQQNF--------DKFKSLRVSTPLTSLKYIRECSPCT 388

  Fly   396 EP---------------TDFVKQAGEEVIAKLLSI-----------IEEIEQKFLAKYPSTE--- 431
            .|               |.|.....|.::..|.|.           ::|:.:.|.....|..
Frog   389 TPISSAMYCVSRLFTILTGFKPAPSERLLQMLRSCSRDPTKTILRRLKEMSETFCENTDSVAEKQ 453

  Fly   432 -----AKSRFQLAKSFFFYLLDQILQAEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEA 491
                 .|..|:||:..::.:|:.::..|.:...|||:..:|.|.|    |:.:||:||:|:.:.:
Frog   454 FCRDITKKYFRLAEVLYYKVLESVIDQEKKRLGDIDMSSILEQDV----FHRSLMSCCLEITVFS 514

  Fly   492 YKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTV 556
            ||....||.::..|.::.::|.|:||:|::  :.|| |.|.::||||:|||..||.:||..:|.:
Frog   515 YKPPGNFPSIIVMFELAPYQFYKVIEVVIK--AEEG-LCREVVKHLNNIEEQILECMAWTHDSPL 576

  Fly   557 WEMIAS----------------------------------------------------------- 562
            |:.|..
Frog   577 WDKIRENDGKIPLCEEVLHPQHFEKSGDNGTTGSLTPRRINEIRADASGLGRSVPSSPATLCDRY 641

  Fly   563 ------------------------------------AQLPLPTWLMVNLDRA------------- 578
                                                |..|:|...:|.:..|
Frog   642 SSPAAGTARRRLFVDPDSSSEAGSPAQASPLATDTVATPPVPGQTLVTMATATVTANNGQTVTIP 706

  Fly   579 ---------------------------------------AGPLQ--------------------- 583
                                                   ||||.
Frog   707 VQGIANENGGITFFPVQVNVSSQPHSVTSSVPPLTAQALAGPLNPQQIQGQVSVSQVPASPGQQS 771

  Fly   584 ---------------IFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETELMKDRH 633
                           :|.|:||.|..:|::.||.:|.:.::....||..||.|:.|..||:||||
Frog   772 KQNLTSKLKKASSLTLFCRRVYCLASIRLKDLCLKLDISDELRRKIWTCFEFSLVHCPELIKDRH 836

  Fly   634 LDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFI------------DINEDGE 686
            |||.:|||:|:..:|.: ||..|.:||:.||.||.|.:.|||.|.:            .|.:.|.
Frog   837 LDQLLMCAVYVITKVTK-EDTSFHNIMKCYRVQPHASSHVYRSVLLKKRRRRQSGSSDHILQPGS 900

  Fly   687 P--KVKDI---------------------------------------------IHFYNHTYVPLM 704
            |  ..|||                                             :.|||:.|:..:
Frog   901 PAENTKDICSREPSPVMRSSSTLPVPQPNSAPPTPTRITAAGSNFVEEERGDLVQFYNNIYIEKI 965

  Fly   705 RQFVIDYLNVTPDVSGRASDLQLSPHPKERAAQPKKVTQS--HSLFVSQMSKNEIQQSPNQMV-Y 766
            :.|.:.:     ..|..:....|||:|..||..|:::..|  ||::||..:.:.....|.:.: |
Frog   966 KSFAMRF-----SQSNTSEATPLSPYPSIRAVSPRRIQLSHIHSIYVSTHNDDATTVCPREKICY 1025

  Fly   767 SFCRSPAKDLQAMNEKVRGG-----KR--MLSFGDE-PGLGTMAETKRSKISQVKAVMDD 818
            .|..||||.||.:|..:|.|     ||  :|..|.| |......|...:.|.:::.|.:|
Frog  1026 YFDLSPAKRLQEINSMIRTGETPTKKRGILLEDGSESPAKRICQENHSALIRRLQDVAND 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf	NP_525036.2	DUF3452	90..225	CDD:288762	47/136 (35%)
		RB_A	376..560	CDD:280101	58/219 (26%)
		RB_B	582..704	CDD:280100	54/216 (25%)
rbl2	XP_002937369.2	DUF3452	78..209	CDD:371807	47/135 (35%)
		RB_A	389..580	CDD:366846	54/197 (27%)
		Atrophin-1	604..>773	CDD:367360	9/168 (5%)
		RB_B	784..966	CDD:366845	53/182 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4098
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	1	1.000	-	-		otm47588
Panther	1	1.100	-	-	LDO	PTHR13742
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3203
SonicParanoid	1	1.000	-	-		X2053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190