DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16989 and HEATR6

DIOPT Version :9

Sequence 1:	NP_001284761.2	Gene:	CG16989 / 31026	FlyBaseID:	FBgn0025621	Length:	1045	Species:	Drosophila melanogaster
Sequence 2:	NP_071353.4	Gene:	HEATR6 / 63897	HGNCID:	24076	Length:	1181	Species:	Homo sapiens

Alignment Length:	1106	Identity:	307/1106 - (27%)
Similarity:	484/1106 - (43%)	Gaps:	188/1106 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DQEEADRDSHLQLVREVDHNVGVPVGVA----------AYRL-----QQLIAGVRARGHHDLLRL 64
            |...|..:.||...:.:..|.....|||          |.||     ..|::.|....||.|.||
Human    44 DSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRL 108

  Fly    65 WQLWLNE----LILAKKIILVR-----SHLLIEELLAGTELKPSVETVNLMLTVLKSTPKENLAG 120
             |:.::|    .:||..|..:.     :|..|.:.||........:....:..:|.:|      |
Human   109 -QVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNT------G 166

  Fly   121 FWPRLSALTHAKDMDVALLLLQCQDRVLAELEESPEVAEHNQGLVNSLINMHFEGRWLVAKEQLP 185
            ...:||.|..: |.:|....:.|...:...:...|.:.|..|       |:.|:....:.  |.|
Human   167 LLMKLSDLAQS-DPEVRRAAVHCMANLCLSVPGQPYLEEPYQ-------NVCFQAFLTIL--QSP 221

  Fly   186 -----------LLLAQSLQLIQKLVT--RQPDYAAQRVPELMGLVQCYLQYGAEGETHLKPRKLP 237
                       :||..:|:.||.|:.  |........:..|:.:::.::.:|..|.....|..|.
Human   222 KSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLY 286

  Fly   238 PAQQSAAYGQEKEEEDQLLAQMSRPCGRKNKVRKMRSLAKQRNQAVNEHHEPNPR-ERLVLMGNQ 301
            |.......|:...:..|..:..|||  ..||.:|.:...|:..|...|..|.:.. |...:.|..
Human   287 PTPLPQYDGRTPIKPQQSESSASRP--TLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTG 349

  Fly   302 DYGCLTGDS------GENGLPSD-----------------------------SDQQQTENKHHRH 331
            ......|::      |...||.|                             ||.:.......|.
Human   350 RVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRS 414

  Fly   332 QEAKVRISALHLLSTLTNQLPRRSFYGYWHVLFPDGDAGGTPH---LLLLGLKDTNFRCRALALQ 393
            .:||||..||....:....:.::..||||....||....|:|.   |:.|.|||.:.:.||.|||
Human   415 YQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQ 479

  Fly   394 VGAQLLYGSKAFLSQACSLGPSN--FTPFAVSLASSVLTAYRILIAILEREYTPPVLTQCLKCLA 456
            |.:.:|.|||.|||.|.......  ||||:|.:|.|:...:|.|:..|..|.:...:||.:||||
Human   480 VLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLA 544

  Fly   457 VLVQATPFHQLEMGFVYEFVGHVKKLIKSSDPPVAVSALLVMEMLVGTSKLTPEI------ASSI 515
            .||...|:.:|::..:.:....:|..|:..|..|.||:|.::..:|.|....||:      ..|.
Human   545 NLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSS 609

  Fly   516 GLAPSQRNLQMEHASTAETYQELCDSDAEMELEEGDEQQQPSQNNVVNPVHTVSPTIPRNSWLLR 580
            ||..|  |....|.|..:.:::   :.|...|||         .:|.:|..:..|     .||:|
Human   610 GLGNS--NSATPHLSPPDWWKK---APAGPSLEE---------TSVSSPKGSSEP-----CWLIR 655

  Fly   581 QVLRCLEGMRI--------------------PSAVRLECFQVLQAMAT-HIGLLRGHQVRLSRVI 624
               .|:..:.:                    ||.:|||..|||..:|. :..:.:.:.:.|..||
Human   656 ---LCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVI 717

  Fly   625 --SAGLTDPATDVKLYAARCLDSVGYQL-GRLLPE----PAERE---LQMSFWLTLL--PATYEA 677
              ..|..||:  ::|:.|:.|:.:|..| .:..|:    |.:|.   |.:.||..:|  |.....
Human   718 CKCMGEADPS--IQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRAL 780

  Fly   678 YDSAGFSLKCALCDALSNMGAISFERLPDGQRTALLAFLSGCASDDHEETLVRVAALRAMAVYVL 742
            .:|...:|:.:.|||||::...:|..||:.::...:..|.|.  :|.:..||:.|..||:.||||
Human   781 QNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGL--NDSKNRLVKAATSRALGVYVL 843

  Fly   743 HPSLRTDLGFVENAAELTLRILGDSQLLARIKAAWALGNISDALVAGI----PNQTERISAELLE 803
            .|.||.|:.||.:||...|..|.|..|..|.||||:|||::|.|:..:    |:..|..|..||.
Human   844 FPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLL 908

  Fly   804 RLIQAATKSCADNDKVRANAVRALGNLLQILQ---VQPLGNGELMQVAMSKLLDCVTLPGNAKVK 865
            :::::|.::..|.|||::||||||||||..||   ::.....|:::.::..|:..|......||:
Human   909 KMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVR 973

  Fly   866 WNACYVIGNLVKHRAF---------FANNRLAGILFPTLCQLVVQHANFKVRTNAAGVLLQVKQR 921
            |||||.:||:.|:.|.         .|.|.|..::  |.|:      |||||..:|..|....:|
Human   974 WNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVV--TSCK------NFKVRIRSAAALSVPGKR 1030

  Fly   922 EDFSA--HFPLLWRSLLDALVRSNVLESFEEYNHRDALQQQLCLAIAHLLLLARSSDLPMMRESL 984
            |.:.:  .:..:|.:|:.||.:|.....|.|:.:..:|:.|:|.|:.|||.||.:||||.|:|:|
Human  1031 EQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETL 1095

  Fly   985 E 985
            |
Human  1096 E 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16989	NP_001284761.2	DUF4042	335..511	CDD:404188	63/180 (35%)
		HEAT repeat	712..745	CDD:293787	12/32 (38%)
		SRP1	721..>830	CDD:227396	49/112 (44%)
		HEAT repeat	755..785	CDD:293787	14/29 (48%)
		HEAT repeat	800..829	CDD:293787	13/28 (46%)
		HEAT repeat	845..875	CDD:293787	10/29 (34%)
		HEAT repeat	889..917	CDD:293787	9/27 (33%)
		HEAT repeat	928..950	CDD:293787	6/21 (29%)
HEATR6	NP_071353.4	HEAT 1	159..198		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..347		13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..390		1/18 (6%)
		DUF4042	418..599	CDD:289992	63/180 (35%)
		HEAT 2	452..490		16/37 (43%)
		HEAT 3	515..552		13/36 (36%)
		HEAT 4	558..595		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..646		10/46 (22%)
		HEAT repeat	810..843	CDD:293787	10/34 (29%)
		HEAT_EZ	830..883	CDD:290247	27/52 (52%)
		HEAT repeat	857..886	CDD:293787	14/28 (50%)
		HEAT repeat	909..934	CDD:293787	11/24 (46%)
		HEAT repeat	957..983	CDD:293787	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147872
Domainoid	1	1.000	207	1.000	Domainoid score	I2904
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11116
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2807
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46845
OrthoDB	1	1.010	-	-		D106835at2759
OrthoFinder	1	1.000	-	-		FOG0007369
OrthoInspector	1	1.000	-	-		oto90154
orthoMCL	1	0.900	-	-		OOG6_104402
Panther	1	1.100	-	-	LDO	PTHR13366
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5863
SonicParanoid	1	1.000	-	-		X5488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940