DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and Pomt1

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	XP_036018637.1	Gene:	Pomt1 / 99011	MGIID:	2138994	Length:	748	Species:	Mus musculus

Alignment Length:	777	Identity:	246/777 - (31%)
Similarity:	369/777 - (47%)	Gaps:	151/777 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TRFYKVTEPDHICWDETHFGKMGSWYINRTFFF-DVHPPLGKMLIGLSGYLTGYNGTFPFEKPGD 116
            ||.::::.|..:.:||.::|:..|:|:.|.||. |..||.|.||:.|.|:|.|::|.|.:.:.|.
Mouse    53 TRLWQLSYPRAVVFDEVYYGQYISFYMKRIFFLDDSGPPFGHMLLALGGWLGGFDGNFLWNRIGA 117

  Fly   117 KY-NETRYQGMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPI 180
            :| :......:|......|||.:||.:..|.:|..||.||:.||..::.:..|:|.::.:||:.|
Mouse   118 EYSSNVPIWSLRLLPALAGALSVPMAYQIVLELHFSHGAAIGAALLMLIENALITQSRLMLLESI 182

  Fly   181 LLFFMMASVWGMVKVSKSTASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATEL 245
            |:||.:.:|...:|...| .:...:.:.|||||.|||...||.:.:|::|:|..|||....|...
Mouse   183 LIFFNLLAVLSYLKFFNS-QTHSPFSVHWWLWLLLTGVSCSCAVGIKYMGIFTYLLVLGIAAVHA 246

  Fly   246 WLILGDLGQPILETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGN 310
            |.::||.....:..:..|..|.:.|:|.||.||:||||:||.:|.|||..|...|||||:.|.|.
Mouse   247 WNLIGDQTLSNMRVLSHLLARIVALLVVPVFLYLLFFYVHLMLLYRSGPHDQIMSSAFQASLEGG 311

  Fly   311 -SLYNASMPRDVAYGSLVTIK--NHKTGGGYLHSHHHLYP------KGSGARQQQVTTYTHKDEN 366
             :......|.:||:||.||:|  :.|....:||||.:.||      :|| :.|||||.|..||.|
Mouse   312 LARITQGQPLEVAFGSQVTLKSVSGKPLPCWLHSHKNTYPMIYENGRGS-SHQQQVTCYPFKDIN 375

  Fly   367 NKWLIRP--------HNKPGPPKGKVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGY 423
            |.|:::.        :|.|.|       :||||:|:|.|..|.|.|::|:..||::....:|:.|
Mouse   376 NWWIVKDPGRHQLVVNNPPRP-------VRHGDIVQLVHGMTTRLLNTHDVAAPLSPHSQEVSCY 433

  Fly   424 GELGLG-DANDVWRVLIVGGKVN-ETVHTVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEV--- 483
            .:..:. .|.::|::.||..:.| :|..|:.|.::|:|:..:..|..||..||.|||.|.||
Mouse   434 IDYNISMPAQNLWKLDIVNRESNRDTWKTILSEVRFVHVNTSAILKLSGAHLPDWGFRQLEVVGE 498

  Fly   484 SCNPNVRDKNSQWNVEDNEHKLMPS-----VSFSVYAP---------GFFARFLESHAVMLQGNA 534
            ..:|...: :..||||  ||:...|     ....:::|         .|.|||.|....||.
Mouse   499 KLSPGYHE-SMVWNVE--EHRYGKSHEQKERELELHSPTQLDISRNLSFMARFSELQWKMLT--- 557

  Fly   535 GLKPK--EGEVTSRPWQW---PINYRGQFFSGSSYRIYLLGNPLIWWS----NLVFLALFVTVFL 590
             ||.:  |.:.:|.|.:|   ..|........:|.:|:||||.:||.|    .:|:..||....|
Mouse   558 -LKNEDLEHQYSSTPLEWLTLDTNIAYWLHPRTSAQIHLLGNIVIWTSASLATVVYTLLFFWYLL 621

  Fly   591 CNAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAKEIVPKAVPSGSPEAP 655
                 ::||:                               ||                   :.|
Mouse   622 -----RRRRS-------------------------------IC-------------------DLP 631

  Fly   656 NPAQS--LRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNYILRVLPKWIHH 718
            ..|.|  :.|.|....||.|:||||:.|.|||:.:||.|||.|..||           ||..:.|
Mouse   632 EDAWSRWVLAGALCTGGWALNYLPFFLMERVLFLYHYLPALTFQILL-----------LPIVLQH 685

  Fly   719 VILGL--------VLSILV---YSFAA-----FSPLAYGMSGPLANEPNSTMYNLKWLSTWE 764
            ....|        |.|.||   ||.|.     ..||.||.:.....|    :..|:|..:|:
Mouse   686 ASDHLCRSQLQRNVFSALVVAWYSSACHVSNMLRPLTYGDTSLSPGE----LRALRWKDSWD 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	246/777 (32%)
		PMT	44..290	CDD:280519	84/238 (35%)
		MIR	318..374	CDD:197746	28/71 (39%)
		MIR	385..440	CDD:197746	17/55 (31%)
		MIR	446..501	CDD:197746	21/57 (37%)
		PMT_4TMC	518..763	CDD:292810	73/271 (27%)
Pomt1	XP_036018637.1	PMT1	56..744	CDD:224839	244/774 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810