DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and PMT3

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_014966.1	Gene:	PMT3 / 854499	SGDID:	S000005848	Length:	753	Species:	Saccharomyces cerevisiae

Alignment Length:	761	Identity:	261/761 - (34%)
Similarity:	388/761 - (50%)	Gaps:	110/761 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LLLATVFLVT-FATRFYKVTEPDHICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTG 104
            :::..:|.|. ..||.||:...:|:.|||.||||.||:|:...|:.||||||||||:||||||.|
Yeast    58 IVMPIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAG 122

  Fly   105 YNGTFPFEKPGDKYNE-TRYQGMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGL 168
            |||::.|.. |:.|.: ..|..||.|.....:|.:|:.:.|...:..|..:..|....:||:...
Yeast   123 YNGSWDFPS-GEVYPDYIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSY 186

  Fly   169 LTLNQYILLDPILLFFMMASVWGMVKVSKSTASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFV 233
            .||.::||||.:||||.::|.:.:.|.  .|.....:..||||||.|||..|.|.||||.||||:
Yeast   187 ATLGKFILLDSMLLFFTVSSYFCLAKF--HTMRKSPFSARWWLWLCLTGLNLGCAISVKMVGLFI 249

  Fly   234 VLLVGLHTATELWLILGDLGQPILETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGF 298
            :.:||::|.:|||.:|.|........|.....|...||:.||.:::|.|.||..:|:.||.||..
Yeast   250 ISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKIHFDLLSNSGPGDST 314

  Fly   299 YSSAFQSRLIGNSLYNASMPRDVAYG-SLVTIKNHKTGGGYLHSHHHLYPKGSGARQQQVTTYTH 362
            ..|.||:.|.|..:  ...|||||.| |:::|||...||..||||...:|:||  .|||||.|.:
Yeast   315 MPSLFQASLNGTKV--GKGPRDVALGSSIISIKNQALGGALLHSHVQPFPEGS--EQQQVTVYGY 375

  Fly   363 KDENNKWL------IRP----HNKPGPPKGKVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKH 417
            .|.||:|.      :.|    .||      .::.::.|::.||.|..|.:|||:|..|||::|..
Yeast   376 SDANNEWFFQRIRGVEPWTDAENK------TIEFVKGGEMYRLMHRLTGKNLHTHEVPAPISKSE 434

  Fly   418 LQVTGYGELGLGDANDVWRVLIVG--GKVNET-VHTVTSRLKFIHLLQNCALTSSGKQLPKWGFE 479
            .:|:.||::.|||..|.|.:.||.  |:.:.| :|.:::..:..:.:..|.|..|||.||:|||.
Yeast   435 YEVSAYGDVDLGDYKDNWIIEIVEQVGEEDPTLLHPLSTSFRIKNSILGCYLAQSGKHLPEWGFR 499

  Fly   480 QQEVSC--NPNVRDKNSQWNVEDNEHKLMPSVSFSVY-APGFFARFLESHAVMLQGNAGLKP--- 538
            |.||.|  :.:.|||.:.||:|.:|::.:|.....|| ...||..|::.::.|:..|..|.|
Yeast   500 QGEVVCLKHASKRDKRTWWNIETHENERLPQGEDFVYPKTSFFRNFMQLNSAMMATNNALVPNPE 564

  Fly   539 KEGEVTSRPWQWP---INYRGQFFSGSSYRIYLLGNPL-IWWSNLVFLALFVTVFLCNAVVQQRR 599
            |...:.|..||||   :..|...:|..|.:.:|||:|. :|.|::...||.:.|.......|::
Yeast   565 KFDGIASSAWQWPTLNVGVRLCEWSEKSIKYFLLGSPASVWPSSIAVCALIIHVIFLTLKWQRQ- 628

  Fly   600 AGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAKEIVPKAVPSGSPEAPNPAQSLRAA 664
                                                |....:.|.:.|            .:.||
Yeast   629 ------------------------------------CVILSDPVERDV------------FVMAA 645

  Fly   665 AWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNYILRVLPKWI-----------HH 718
            .:..|.|:|||:||..|.||:|.|||.|.|.|..::....::.|.:   :|.           .:
Yeast   646 FYPLLAWLLHYMPFVVMSRVVYAHHYLPTLYFALMILSYYFDMITK---RWATRNTGKFLRLGAY 707

  Fly   719 VILGLVLSILVYSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWE 764
            ::.|   ||::..|..|||.::||.||:    :...| |.||.||:
Yeast   708 IVYG---SIVIAGFFYFSPFSFGMDGPV----DDYAY-LAWLPTWQ 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	261/761 (34%)
		PMT	44..290	CDD:280519	102/247 (41%)
		MIR	318..374	CDD:197746	30/66 (45%)
		MIR	385..440	CDD:197746	21/54 (39%)
		MIR	446..501	CDD:197746	22/57 (39%)
		PMT_4TMC	518..763	CDD:292810	65/262 (25%)
PMT3	NP_014966.1	PMT1	31..750	CDD:224839	261/761 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346596
Domainoid	1	1.000	192	1.000	Domainoid score	I625
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I260
Isobase	1	0.950	-	0	Normalized mean entropy	S1660
OMA	1	1.010	-	-		QHG52910
OrthoFinder	1	1.000	-	-		FOG0002698
OrthoInspector	1	1.000	-	-		otm46883
orthoMCL	1	0.900	-	-		OOG6_101353
Panther	1	1.100	-	-	O	PTHR10050
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3468
TreeFam	1	0.960	-	-
	14	13.710