Protein Alignment tw and PMT4

DIOPT Version :10

• Sequence 1: NP_569858.1
• Gene: tw / 31024
• FlyBaseID: FBgn0086368
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_012677.1
• Gene: PMT4 / 853608
• SGDID: S000003904
• Length: 762
• Species: Saccharomyces cerevisiae
• Alignment Length: 825
• Identity: 239/825 - (28%)
• Similarity: 369/825 - (44%)
• Gaps: 175/825 - (21%)

  Fly     6 VKTPKCPRRG----SVKDV-------AQNAPR---------TAPTSSKEANWNWWLLLATVFLVT 50
            :..||....|    |.|||       .:.||:         ..|....|:.:::|:.:.|  |:.
Yeast     1 MSVPKKRNHGKLPPSTKDVDDPSLKYTKAAPKCEQVAEHWLLQPLPEPESRYSFWVTIVT--LLA 63

  Fly    51 FATRFYKVTEPDHICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPG 115
            ||.||||:..|..:.:||.||||..|:|:.|::|||||||..||:|...|:|.||:|:|.|::.|
Yeast    64 FAARFYKIWYPKEVVFDEVHFGKFASYYLERSYFFDVHPPFAKMMIAFIGWLCGYDGSFKFDEIG 128

  Fly   116 DKYNETR---YQGMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILL 177
            ..| ||.   |...|.|...||.|.:|:.|:|:.:|.........|:..:..|...:|..:.|||
Yeast   129 YSY-ETHPAPYIAYRSFNAILGTLTVPIMFNTLKELNFRAITCAFASLLVAIDTAHVTETRLILL 192

  Fly   178 DPILLFFMMASVWGMVKVSKSTASGGSYGLR------WWLWLFLTGTMLSCTISVKFVGLFVVLL 236
            |.||:..:.|:::..|:..|..       ||      |::||..||..||..||.|:||:.....
Yeast   193 DAILIISIAATMYCYVRFYKCQ-------LRQPFTWSWYIWLHATGLSLSFVISTKYVGVMTYSA 250

  Fly   237 VGLHTATELWLILGDL--GQPILETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFY 299
            :|......||.:| |:  |..:.:.::..:.|...|::.|.::|:.:|::|.:|||.||.||.|.
Yeast   251 IGFAAVVNLWQLL-DIKAGLSLRQFMRHFSKRLNGLVLIPFVIYLFWFWVHFTVLNTSGPGDAFM 314

  Fly   300 SSAFQSRLIGNSLYNASMPRDVAYGSLVTIKNHKTGGGYLHSHHHLYPK--------GSGARQQQ 356
            |:.||..|..:.|...|  :.|.|..::||| |:....:||||...||:        .:|   ||
Yeast   315 SAEFQETLKDSPLSVDS--KTVNYFDIITIK-HQDTDAFLHSHLARYPQRYEDGRISSAG---QQ 373

  Fly   357 VTTYTHKDENNKW-LIRPHNKPGPPKGKVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQV 420
            ||.|||.|.||:| ::.||   |...||.|.:.....:||.|:||...|.:|:..:|....:.::
Yeast   374 VTGYTHPDFNNQWEVLPPH---GSDVGKGQAVLLNQHIRLRHVATDTYLLAHDVASPFYPTNEEI 435

  Fly   421 T------GYGELGLGDANDVWRVLIVGGKVNETVHTVTSR---LKFIHLLQNCAL-TSSGKQLPK 475
            |      |.||| ..:....::.|    |.::..|.:.|:   .:..|:..:.|| |.:.:.||.
Yeast   436 TTVTLEEGDGEL-YPETLFAFQPL----KKSDEGHVLKSKTVSFRLFHVDTSVALWTHNDELLPD 495

  Fly   476 WGFEQQEVSCNPNVRDKNSQWNVE-----DNEHKLMPSVSFSVYAP------GFFARFLESHAVM 529
            |||:|||::.|..|.|.::.|.|:     |...|        ||.|      .|..:::|:...|
Yeast   496 WGFQQQEINGNKKVIDPSNNWVVDEIVNLDEVRK--------VYIPKVVKPLPFLKKWIETQKSM 552

  Fly   530 LQGNAGLKPKEGEVTSRPWQWPINYRGQFF---SGSSYRIYLLGNPLIWWSNLVFLALFVTVFLC 591
            .:.|..|. .|....|.|:.||.:..|..|   .....:||.:||.:.||..::.||:||.:.:.
Yeast   553 FEHNNKLS-SEHPFASEPYSWPGSLSGVSFWTNGDEKKQIYFIGNIIGWWFQVISLAVFVGIIVA 616

  Fly   592 NAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAKEIVPKAVPSGSPEAPN 656
            :.:.:.|  |:   .|.|:                         .|..|...|
Yeast   617 DLITRHR--GY---YALNK-------------------------MTREKLYGP------------ 639

  Fly   657 PAQSLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNYI------------- 708
                   ..:.|:.|..||.||:.|.|..:.|||.||.:...|.:|.::..|
Yeast   640 -------LMFFFVSWCCHYFPFFLMARQKFLHHYLPAHLIACLFSGALWEVIFSDCKSLDLEKDE 697

  Fly   709 ------------LRVLPKWIHHVILGLVLSILVYSFAAFSPLAYG 741
                        :.|.|   :.|.|..|...:.:.|..||||.||
Yeast   698 DISGASYERNPKVYVKP---YTVFLVCVSCAVAWFFVYFSPLVYG 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_569858.1	PMT	44..290	CDD:396786	88/256 (34%)
		beta-trefoil_MIR_POMT2	321..503	CDD:467753	65/205 (32%)
		PMT_4TMC	520..761	CDD:465056	56/250 (22%)
PMT4	NP_012677.1	PMT	58..305	CDD:396786	88/257 (34%)
		beta-trefoil_MIR_PMT4-like	334..521	CDD:467756	64/198 (32%)
		PMT_4TMC	543..755	CDD:465056	56/250 (22%)