DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and PMT6

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_011715.1	Gene:	PMT6 / 853113	SGDID:	S000003431	Length:	759	Species:	Saccharomyces cerevisiae

Alignment Length:	760	Identity:	256/760 - (33%)
Similarity:	379/760 - (49%)	Gaps:	110/760 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LLATVFLVTFATRFYKVTEPDHICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYN 106
            ||.|:  .:|..||..:.:.:::.|||.||||.||:||...::.|||||||||||.||.::.|::
Yeast    70 LLLTI--TSFYLRFQHIDQNNYVVWDEAHFGKFGSYYIKHEYYHDVHPPLGKMLIALSEWMAGFD 132

  Fly   107 GTFPFEKPGDKYNETRYQGMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTL 171
            |.|.|...........::.||.|..|.|||..|:.|.|...:..::....|.|..:..:...:.|
Yeast   133 GQFDFSSNNAYPENVNFKLMRQFNATFGALCTPVAFFTAKWMGFNYFTVYLIATMVTLEHSYIVL 197

  Fly   172 NQYILLDPILLFFMMASVWGMVKVSKSTASGGSYGLR-------WWLWLFLTGTMLSCTISVKFV 229
            :::||||.:||||.|.:...|:|:         |.||       |.||:.|||..:.|..|||:|
Yeast   198 SKFILLDSMLLFFSMTTFACMIKL---------YTLRKQQMTKKWSLWMLLTGLSIGCVCSVKWV 253

  Fly   230 GLFVVLLVGLHTATELWLILGDLGQPILETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGN 294
            |||:.::|||:|..||:|:..|...|.::..|....|.|.|||.|.|:|:..|.||..:|.:||.
Yeast   254 GLFITVVVGLYTCIELFLLYCDKELPRIKYYKHWLIRIINLIVIPFLIYLYCFKIHFVLLYKSGT 318

  Fly   295 GDGFYSSAFQSRLIGNSLYNASMPRDVAYGSLVTIKNHKTGGGYLHSHHHLYPKGSGARQQQVTT 359
            ||...::.||..|.|..:  .:.|||||:||.:||::|......||||..:||:|||  |:|:|.
Yeast   319 GDSTTNTLFQINLEGTQI--EAGPRDVAFGSELTIRSHGLSPNLLHSHIQVYPEGSG--QRQITG 379

  Fly   360 YTHKDENNKWLIR-------PHNKPGPPKGKVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKH 417
            |...|.||.|...       ..::.|...||:..:..|..|||:|..|..|||||:.|:.:::.:
Yeast   380 YGFADSNNVWKFEFSRSSGLELDQNGTLNGKIIPITDGVEVRLSHKNTGSNLHSHDVPSHVSRGN 444

  Fly   418 LQVTGYGELGLGDANDVWRVLIVG---------GKVNETV-HTVTSRLKFIHLLQNCALTSSGKQ 472
            .:|:|||...:||..|.|.|.||.         ...|.|: |.|::..:..|.:..|.|.|:|..
Yeast   445 YEVSGYGSQSVGDEKDDWIVEIVKQMDSPNPVYSNENSTILHPVSTFFRLRHKVLGCYLASTGLT 509

  Fly   473 LPKWGFEQQEVSCNP--NVRDKNSQWNVEDN-EHKLMPSVSFSVYAPGFFARFLESHAVMLQGNA 534
            .|.|||:|.|:.|..  :.|||::.|||||: .|.|..:..:......|:..|:.::..|...|.
Yeast   510 YPAWGFKQAEIVCKDSWSRRDKSTWWNVEDHWNHNLETAEDYVPPKSNFWTDFILTNFAMASSNN 574

  Fly   535 GLKPKEGE---VTSRPWQWPINYRG-QFFSGSSY--RIYLLGNPLIWWSNLVFLALFVTVFLCNA 593
            .|.|.|.:   ::|..|:||..::| :..|.:.|  |.||:|:|...|.:.|.|.:|..:.|. .
Yeast   575 ALVPDEDKYDSLSSDAWEWPTLHKGLRMCSWAGYITRYYLMGSPFNTWISTVSLIIFPFIILF-I 638

  Fly   594 VVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAKEIVPKAVPSGSPEAPNPA 658
            :.:.||                 :|:...::.....|        .:.|.|
Yeast   639 LYRWRR-----------------QTLYLSDDQIWQIT--------IQGIFP-------------- 664

  Fly   659 QSLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNYIL-RVLPKWIHHVILG 722
                     |:.||.|||||..||||.|.|||.|||.|..|:.|.:.::.| ||  .|:  |...
Yeast   665 ---------FISWMTHYLPFAMMGRVTYVHHYVPALYFAMLVFGFVLDFTLTRV--HWM--VKYP 716

  Fly   723 LVLSIL---VYSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWE 764
            :.||:.   :|.:..|:|:..||.|..|.     ...|:|||||:
Yeast   717 IYLSLFGGCIYIYNLFAPICQGMHGDKAE-----YLPLQWLSTWD 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	256/760 (34%)
		PMT	44..290	CDD:280519	94/252 (37%)
		MIR	318..374	CDD:197746	27/62 (44%)
		MIR	385..440	CDD:197746	21/54 (39%)
		MIR	446..501	CDD:197746	22/57 (39%)
		PMT_4TMC	518..763	CDD:292810	70/254 (28%)
PMT6	NP_011715.1	PMT1	44..759	CDD:224839	256/760 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I625
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I260
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52910
OrthoFinder	1	1.000	-	-		FOG0002698
OrthoInspector	1	1.000	-	-		otm46883
orthoMCL	1	0.900	-	-		OOG6_101353
Panther	1	1.100	-	-	O	PTHR10050
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	1	1.000	-	-		X3468
TreeFam	1	0.960	-	-
	13	12.860