DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and PMT1

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_010188.1	Gene:	PMT1 / 851462	SGDID:	S000002253	Length:	817	Species:	Saccharomyces cerevisiae

Alignment Length:	779	Identity:	256/779 - (32%)
Similarity:	371/779 - (47%)	Gaps:	97/779 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RRGSVKDVAQNAP-------RTAPTSSKEANWNWWLLLATVFLVTFATRFYKVTEPDHICWDETH 70
            ::|.|:......|       ||..|..::      ||:|.:.:.|...|.:.:..||.:.:||.|
Yeast    22 KQGPVRPFIVTDPSAELASLRTMVTLKEK------LLVACLAVFTAVIRLHGLAWPDSVVFDEVH 80

  Fly    71 FGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKY-NETRYQGMRYFCTTLG 134
            ||...|.||..|:|.||||||.|||......|.|:.|.|.||..||.: :.|.|..||:|..:||
Yeast    81 FGGFASQYIRGTYFMDVHPPLAKMLYAGVASLGGFQGDFDFENIGDSFPSTTPYVLMRFFSASLG 145

  Fly   135 ALIMPMGFDTV-YDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASVWGMVKVSKS 198
            ||.:.:.:.|: |...|.. .||::|.....:...:|:::|||||..|:||:.|:|:...|....
Yeast   146 ALTVILMYMTLRYSGVRMW-VALMSAICFAVENSYVTISRYILLDAPLMFFIAAAVYSFKKYEMY 209

  Fly   199 TASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDLGQPILETVKQL 263
            .|:    .|..:..|..||..|....|.|:||||.|..|||.....||.::|||.:......|..
Yeast   210 PAN----SLNAYKSLLATGIALGMASSSKWVGLFTVTWVGLLCIWRLWFMIGDLTKSSKSIFKVA 270

  Fly   264 ACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPRDVAYGSLVT 328
            ..:...|:..|..||::|||||...|...|:|..|:|..|:|.|..|.: ..::..||..||:::
Yeast   271 FAKLAFLLGVPFALYLVFFYIHFQSLTLDGDGASFFSPEFRSTLKNNKI-PQNVVADVGIGSIIS 334

  Fly   329 IKNHKTGGGYLHSHHHLYPKGSGARQQQVTTYTHKDENNKWLIRPHNKPGPPKGKVQILRHGDLV 393
            :::..|.|||||||.|.||.||  .|||.|.|.|.|.||.||:..:|.||......|.|..|..|
Yeast   335 LRHLSTMGGYLHSHSHNYPAGS--EQQQSTLYPHMDANNDWLLELYNAPGESLTTFQNLTDGTKV 397

  Fly   394 RLTHMATRRNLHSHNEPAPMTKK---HLQVTGYGELGL-GDANDVWRVLI-----VGGKVNETVH 449
            ||.|..||..||||:...|:::.   ..:|:.||..|. |||||.|.|.|     ..|...|.|.
Yeast   398 RLFHTVTRCRLHSHDHKPPVSESSDWQKEVSCYGYSGFDGDANDDWVVEIDKKNSAPGVAQERVI 462

  Fly   450 TVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSCNPNVRDKNSQWNVEDNEHKLMPSVSFSV- 513
            .:.::.:..|.:..|.|.|...:||.||||||||:|..:.|...:.|.||:|.:.|:|..:..:
Yeast   463 ALDTKFRLRHAMTGCYLFSHEVKLPAWGFEQQEVTCASSGRHDLTLWYVENNSNPLLPEDTKRIS 527

  Fly   514 YAP-GFFARFLESHAVMLQGNAGL-KPKEGEVTSRPWQWPINYRGQFFSGSSYR-IYLLGNPLIW 575
            |.| .|.::|:|||..|...|..| :|...|  |:|..||...||..:.|.:.| :|||||.::|
Yeast   528 YKPASFISKFIESHKKMWHINKNLVEPHVYE--SQPTSWPFLLRGISYWGENNRNVYLLGNAIVW 590

  Fly   576 WSNLVFLALFVTVFLCNAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAK 640
            |:...|:.:|..:.:......|          ..:..:.||:.|....:..|
Yeast   591 WAVTAFIGIFGLIVITELFSWQ----------LGKPILKDSKVVNFHVQVIH------------- 632

  Fly   641 EIVPKAVPSGSPEAPNPAQSLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTG--- 702
                                      ..||:.:||.|.:.|.|.::.|||.||..|..|..|
Yeast   633 --------------------------YLLGFAVHYAPSFLMQRQMFLHHYLPAYYFGILALGHAL 671

  Fly   703 -VMYNYILRVLPKWIHHVILGLVLSILVYSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWEF 765
             ::.:|:.|...:..:.|:: ..|:..||.|.:|||:.||.  |...|   .....:|||.|::
Yeast   672 DIIVSYVFRSKRQMGYAVVI-TFLAASVYFFKSFSPIIYGT--PWTQE---LCQKSQWLSGWDY 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	250/742 (34%)
		PMT	44..290	CDD:280519	90/247 (36%)
		MIR	318..374	CDD:197746	28/55 (51%)
		MIR	385..440	CDD:197746	26/63 (41%)
		MIR	446..501	CDD:197746	21/54 (39%)
		PMT_4TMC	518..763	CDD:292810	64/250 (26%)
PMT1	NP_010188.1	PMT1	26..733	CDD:224839	255/775 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1660
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002698
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101353
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.660