Protein Alignment tw and PMT2

DIOPT Version :10

• Sequence 1: NP_569858.1
• Gene: tw / 31024
• FlyBaseID: FBgn0086368
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_009379.2
• Gene: PMT2 / 851210
• SGDID: S000000021
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 789
• Identity: 267/789 - (33%)
• Similarity: 386/789 - (48%)
• Gaps: 108/789 - (13%)

  Fly    16 SVKDVAQNA-PRTAPTSSKE---ANWNWWLLLATVFLVTFA-----TRFYKVTEPDHICWDETHF 71
            ||.:...:| .|.|...|||   |..:...|.:.|..|.|.     ||.||:...:|:.|||.||
Yeast    32 SVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVVWDEAHF 96

  Fly    72 GKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKYNE-TRYQGMRYFCTTLGA 135
            ||.||:|:...|:.||||||||||:||||||.||||::.|.. |:.|.: ..|..||.|..:..|
Yeast    97 GKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPS-GEIYPDYLDYVKMRLFNASFSA 160

  Fly   136 LIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASVWGMVKVSKSTA 200
            |.:|:.:.|...:..|.....|....::|:....||.::||||.:||||.:||.:..|......:
Yeast   161 LCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRS 225

  Fly   201 SGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDLGQPILETVKQLAC 265
            .  .:..:||.||.:||..|.||||||.||||::.:||::|..:||..|.|........:.....
Yeast   226 K--PFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLA 288

  Fly   266 RAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPRDVAYG-SLVTI 329
            |...||:.|..:::|.|.||..:|:.||.||....|.||:||:|:.:  ...|||:|.| |:|:|
Yeast   289 RIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQARLVGSDV--GQGPRDIALGSSVVSI 351

  Fly   330 KNHKTGGGYLHSHHHLYPKGSGARQQQVTTYTHKDENNKWLIRPHNKPGPP-----KGKVQILRH 389
            ||...||..||||...||.||  .|||||.|.:||.||:|..  :.:.|.|     :..::.|:.
Yeast   352 KNQALGGSLLHSHIQTYPDGS--NQQQVTCYGYKDANNEWFF--NRERGLPSWSENETDIEYLKP 412

  Fly   390 GDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIV---GGKVNETVHTV 451
            |...||.|.:|.||||:|...||::|...:|:|||:..:||..|.|.:.|:   |.:..|.:||:
Yeast   413 GTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGDNVVGDNKDNWVIEIMDQRGDEDPEKLHTL 477

  Fly   452 TSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSC--NPNVRDKNSQWNVEDNEHKLMP--SVSFS 512
            |:..:..:|...|.|..:|..||:|||.||||.|  ||..|||.:.||:|.:|::.:|  ...|.
Yeast   478 TTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMKNPFKRDKRTWWNIETHENERLPPRPEDFQ 542

  Fly   513 VYAPGFFARFLESHAVMLQGNAGLKP---KEGEVTSRPWQWP---INYRGQFFSGSSYRIYLLGN 571
            .....|...|:..:..|:..|..|.|   |...:.|..||||   :..|...:...:.:.:|||.
Yeast   543 YPKTNFLKDFIHLNLAMMATNNALVPDPDKFDYLASSAWQWPTLNVGLRLCGWGDDNPKYFLLGT 607

  Fly   572 PLIWWSNLVFLALFVTVFLCNAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCC 636
            |...|::.|.:..|:...:...:..||:....|
Yeast   608 PASTWASSVAVLAFMATVVILLIRWQRQYVDLR-------------------------------- 640

  Fly   637 TPAKEIVPKAVPSGSPEAPNPAQ---SLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNS 698
                               ||:.   .|....:..|.|.|||:||..|.||.|.|||.|||.|..
Yeast   641 -------------------NPSNWNVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFAL 686

  Fly   699 LLTGVMYNYILRVLPKW--------IHHVILGLVLSILVYSFAAFSPLAYGMSGPLANEPNSTMY 755
            ::....::   ..|.||        :..|:....:::::..|..|||:::||.|     |:|...
Yeast   687 IILAYCFD---AGLQKWSRSKCGRIMRFVLYAGFMALVIGCFWYFSPISFGMEG-----PSSNFR 743

  Fly   756 NLKWLSTWE 764
            .|.|.|||:
Yeast   744 YLNWFSTWD 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_569858.1	PMT	44..290	CDD:396786	98/251 (39%)
		beta-trefoil_MIR_POMT2	321..503	CDD:467753	80/192 (42%)
		PMT_4TMC	520..761	CDD:465056	58/257 (23%)
PMT2	NP_009379.2	PMT	69..313	CDD:396786	97/246 (39%)
		beta-trefoil_MIR_PMT2-like	339..531	CDD:467755	83/195 (43%)
		PMT_4TMC	550..749	CDD:465056	58/257 (23%)