DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tw and CG11999

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_649527.1	Gene:	CG11999 / 40637	FlyBaseID:	FBgn0037312	Length:	216	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	56/174 - (32%)
Similarity:	85/174 - (48%)	Gaps:	27/174 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LIGNSLYNASMPRD-VAYGSLVTIKNHKTGGGY---LHSHHHLYPKGSGARQQQVTTYTHK-DEN 366
            |:|:....|:...: |..||::.:.|    ..|   ||||...|  |||:.||.||....| |.|
  Fly    12 LVGSISRGAATESNVVTCGSILKLLN----SDYAFRLHSHDVKY--GSGSGQQSVTGVEQKEDVN 70

  Fly   367 NKWLIRPHN----KPGPPKGKVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGYGELG 427
            :.|:|:...    :.|.|      :..|..|||.|::|::|||||:..:|::.:. :|:.||..|
  Fly    71 SHWVIKAQTGELCERGEP------IACGSTVRLEHLSTKKNLHSHHFSSPLSGEQ-EVSAYGTDG 128

  Fly   428 LGDANDVWRVLIVGGKVNETVHTVTSRLKFIHLLQNCALTSSGK 471
            |||..|.|.|:........:.|.   ||:  |:.....|..||:
  Fly   129 LGDTGDHWEVVCSNENWMRSAHV---RLR--HIDTGMYLGMSGR 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	56/174 (32%)
		PMT	44..290	CDD:280519
		MIR	318..374	CDD:197746	22/60 (37%)
		MIR	385..440	CDD:197746	22/54 (41%)
		MIR	446..501	CDD:197746	7/26 (27%)
		PMT_4TMC	518..763	CDD:292810
CG11999	NP_649527.1	MIR	26..75	CDD:197746	21/54 (39%)
		MIR	86..138	CDD:197746	23/58 (40%)
		MIR	151..>182	CDD:197746	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.770