DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tw and sdf2

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_956333.1	Gene:	sdf2 / 336879	ZFINID:	ZDB-GENE-030131-8823	Length:	222	Species:	Danio rerio

Alignment Length:	236	Identity:	73/236 - (30%)
Similarity:	106/236 - (44%)	Gaps:	51/236 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 VAYGSLVTIKNHKTGGGYLHSHHHLYPKGSGARQQQVT-TYTHKDENNKWLIRPHNKPGPPKGKV 384
            |..||:|.:.|.| ....||||...|  |||:.||.|| ..|.:|.|:.|.:|..:.....:|..
Zfish    32 VTCGSVVKLINVK-HNVRLHSHDVRY--GSGSGQQSVTGVTTVEDSNSYWSVRGTSDHSCHRGTP 93

  Fly   385 QILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIVGG--KVNET 447
              :|.|..:||||:.|.||||||...:|::... :|:.:||.|.||..|.|.||.||.  :.:|:
Zfish    94 --VRCGQNIRLTHVNTGRNLHSHYFTSPLSSNQ-EVSAFGENGEGDHLDEWTVLCVGSIWQRDES 155

  Fly   448 VHTVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSCNPNVRDKNSQWNVEDNEHKLMPSVSFS 512
            |       :|.|......|:.:|:|..:....|:||                   |.:|.|.|.|
Zfish   156 V-------RFQHTATEALLSVTGEQFGRPIHGQREV-------------------HGMMVSSSHS 194

  Fly   513 VYAPGFFARFLESHAVMLQGNAGLKPKEGEVTSRPWQWPIN 553
            .:      |.:|          |:..|..|..||.:..|::
Zfish   195 YW------RTME----------GIFIKPSEAGSRDFHSPLH 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	73/236 (31%)
		PMT	44..290	CDD:280519
		MIR	318..374	CDD:197746	23/53 (43%)
		MIR	385..440	CDD:197746	24/54 (44%)
		MIR	446..501	CDD:197746	10/54 (19%)
		PMT_4TMC	518..763	CDD:292810	8/36 (22%)
sdf2	NP_956333.1	MIR	32..80	CDD:197746	22/50 (44%)
		MIR	91..146	CDD:197746	25/57 (44%)
		MIR	155..200	CDD:197746	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840