DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and POMT2

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	XP_011534977.1	Gene:	POMT2 / 29954	HGNCID:	19743	Length:	813	Species:	Homo sapiens

Alignment Length:	818	Identity:	404/818 - (49%)
Similarity:	523/818 - (63%)	Gaps:	84/818 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRRG---------SVKDVAQNAPRTAPTSSKEANW--------NWWLLLATVFLVTFATRFYKVT 59
            ||||         :.:|||..|...:|   |...|        .||.|||.|.|::|||||:::.
Human    16 PRRGRCGPQAARAAGRDVAAEAVARSP---KRPAWGSRRFEAVGWWALLALVTLLSFATRFHRLD 77

  Fly    60 EPDHICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKYNETRYQ 124
            ||.||||||||||||||:|||||||||||||||||||||:|||:||:|||.|:||||||....|.
Human    78 EPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYM 142

  Fly   125 GMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASV 189
            |||.||..||:.::|..:.||.||::|..||||.||.|.||.|.|||:|||||||||:||:||::
Human   143 GMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAM 207

  Fly   190 WGMVKVSKSTASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDLGQ 254
            ..|||.  ::.:...:...||.||.|||..|:..:.|||||||::|.|||:|..:||.:.|||..
Human   208 LSMVKY--NSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSL 270

  Fly   255 PILETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPR 319
            .::...|.|..|.:.|||.|:.||...|.:|..||::||.||||:|||||:||.||:|:|||:|.
Human   271 SLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPE 335

  Fly   320 DVAYGSLVTIKNHKTGGGYLHSHHHLYPKGSGARQQQVTTYTHKDENNKWLIRPHN---KPGPPK 381
            .:||||::|:||.:...||||||.||||:|.||||||||||.|||.||.|:|:.||   .|..|.
Human   336 HLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPS 400

  Fly   382 GKVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIVGGKVNE 446
            ..|:.:||||::||.|..|.||||||...||||:||.||||||..|.||:||.||:.:|..|...
Human   401 FPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGN 465

  Fly   447 TVHTVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSCNPNVRDK-NSQWNVEDNEHKLMPSVS 510
            .:..:.||::||||:..|.|.||||.|||||:||.||:|.|.:::. ||.|||||:.:..:|::|
Human   466 RIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWNVEDHINPKLPNIS 530

  Fly   511 FSVYAPGFFARFLESHAVMLQGNAGLKPKEGEVTSRPWQWPINYRGQFFSG---SSYRIYLLGNP 572
            ..|..|.|....||||.||::||:|||||:.|.||:||.|||||:|..|||   :.:|:||||||
Human   531 LDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNP 595

  Fly   573 LIWWSNLVFLALFVTVFLCNAVVQQRRAGF-ARSAAQNQAQVPDSETVAQDEESEHSTTDICSCC 636
            ::||.||:.:||::......||..||.|.. |..|.|....:|......|            ..|
Human   596 VVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEVAGQVLWALPPLTWRQQ------------GTC 648

  Fly   637 TPAKEIVPKAVPSGSPEAPN--------------------PAQS-------LRAAAWLFLGWMLH 674
            ||.:..:|...||.:...|:                    |..:       ||....:.|||.||
Human   649 TPGEGRLPADGPSFAFTTPHLPLSFAFERKPRNHEIKKLAPGHTARLSQVLLRGGGQVLLGWTLH 713

  Fly   675 YLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNYILRV----LPKW-----IHHVILGLVLSILV- 729
            |.||:.|||||||||||||::|:|:|||::::.:||:    |..|     ||  :.| :||:|:
Human   714 YFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIH--VAG-ILSLLLG 775

  Fly   730 --YSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWEF 765
              |||..|.||||||.||||.:|.|.|..|:||.:|:|
Human   776 TAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	390/770 (51%)
		PMT	44..290	CDD:280519	140/245 (57%)
		MIR	318..374	CDD:197746	36/55 (65%)
		MIR	385..440	CDD:197746	33/54 (61%)
		MIR	446..501	CDD:197746	29/55 (53%)
		PMT_4TMC	518..763	CDD:292810	117/287 (41%)
POMT2	XP_011534977.1	PMT1	50..813	CDD:224839	392/779 (50%)
		PMT	62..306	CDD:280519	140/245 (57%)
		MIR	334..390	CDD:197746	36/55 (65%)
		MIR	404..459	CDD:197746	33/54 (61%)
		MIR	472..521	CDD:197746	29/48 (60%)
		PMT_4TMC	538..811	CDD:292810	117/287 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159933
Domainoid	1	1.000	292	1.000	Domainoid score	I1522
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5297
Inparanoid	1	1.050	761	1.000	Inparanoid score	I549
Isobase	1	0.950	-	0	Normalized mean entropy	S1660
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101190at33208
OrthoFinder	1	1.000	-	-		FOG0002698
OrthoInspector	1	1.000	-	-		oto90795
orthoMCL	1	0.900	-	-		OOG6_101353
Panther	1	1.100	-	-	LDO	PTHR10050
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	1	1.000	-	-		X3468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740