DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and ogm2

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_594135.1	Gene:	ogm2 / 2543657	PomBaseID:	SPAPB1E7.09	Length:	739	Species:	Schizosaccharomyces pombe

Alignment Length:	771	Identity:	255/771 - (33%)
Similarity:	379/771 - (49%)	Gaps:	94/771 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VKDVAQNAPRTAPTSSKEANWNWWLLLATVFLVTFATRFYKVTEPDHICWDETHFGKMGSWYINR 81
            :||..::|.....|:.|.....::|:...:.::....|.:|:.:.:.:.|||.||||..|:|:..
pombe    35 LKDATKSALGEVKTNKKYYILGYFLVPLLLTVIAGFVRVWKIADSNVVIWDEAHFGKFASYYLKH 99

  Fly    82 TFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKYNETRYQGMRYFCTTLGALIMPMGFDTVY 146
            .|:|||||||||||..::|.|.||:|:|.|........:..|:.||.:....|.|.:|:.:.|..
pombe   100 EFYFDVHPPLGKMLNAVAGKLVGYDGSFDFSSGATYPEDLNYKFMRLWNAAFGTLCIPLVYFTAL 164

  Fly   147 DLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASVWGMVKVSKSTASGGSYGLRWWL 211
            :...|..||.|....:..|..|.|::::||||.:||||::::.:.:.:.  .......:...|:.
pombe   165 NFNYSFLAATLCTLMVALDNHLATISRFILLDSMLLFFIISTFFCLSRY--HVYHKAPFTFYWFK 227

  Fly   212 WLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDLGQPILETVKQLACRAITLIVWPVL 276
            ||||||..:.|..|||.||||:..:|||:|..|||.:|.|..............|...||..|:|
pombe   228 WLFLTGVCIGCVCSVKLVGLFITAVVGLYTVDELWCLLNDKRVTWKAYAGHWIARVCLLIFLPIL 292

  Fly   277 LYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPRDVAYGSLVTIKNHKTGGGYLHS 341
            :|...|:|..:||.|||.||....|.||:||.|:.|  ...|.|:.|||..|:|:....|..|||
pombe   293 IYAFTFWIQFAVLYRSGPGDAQMPSLFQARLEGSPL--TKNPIDLMYGSKFTLKSRNPTGALLHS 355

  Fly   342 HHHLYPKGSGARQQQVTTYTHKDENNKWLIRP---------HNKPGPPKGKVQILRHGDLVRLTH 397
            |...||:||  .|||||.|.|||.||:|:..|         .|.|..|      :.:|.:|||.|
pombe   356 HVQTYPEGS--EQQQVTGYHHKDGNNEWMFVPTHGVAYNYEENDPMNP------ILNGSVVRLIH 412

  Fly   398 MATRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIVGGKVNETVHTVTSRLKFIHLLQ 462
            ..|.||||:|..|||:.|:..:|:|||...:||..|.|.|.|:....:...:.|.| |..:..|.
pombe   413 PFTNRNLHTHKIPAPLNKRMYEVSGYGLGDVGDEKDYWIVNILYDTAHRDAYNVRS-LSTVFQLY 476

  Fly   463 N----CALTSSGKQLPKWGFEQQEVSCNPNVRDKN--SQWNVEDNEHKLMPSVSFSVYAPGFFAR 521
            |    |.|:||...||.|||.|.|:.|:|:....|  :|||||::.:..:|..|.:.|...|::.
pombe   477 NPVVGCYLSSSSSSLPSWGFGQIEMYCDPDPDPSNTDTQWNVEEHINPRLPEGSINDYPSSFWSD 541

  Fly   522 FLESHAVMLQGNAGLKPKEGE---VTSRPWQWPI---NYRGQFFSGSSYRIYLLGNPLIWW---S 577
            ||..:..||:.|.||.|.|.:   :.|..:|||.   ..|...:..:..:..|:|||:.:|   |
pombe   542 FLHLNRAMLRANNGLIPDEDKLDALRSEAYQWPFLLATLRMCGWGDNQIKYLLVGNPVAYWFATS 606

  Fly   578 NLVFLALFVTVFLCNAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAKEI 642
            :|:..||||.    .||:..||
pombe   607 SLIVFALFVV----GAVLAWRR------------------------------------------- 624

  Fly   643 VPKAVPSGSPEAPNPAQSLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNY 707
               .|...|.||.:...  .|..:.||||..:|||::.||||||.|||.|:...::.....:.::
pombe   625 ---RVLRWSQEACDTFH--YAGIYPFLGWFFNYLPYYIMGRVLYVHHYEPSYALSTFTAAFVVDW 684

  Fly   708 ILRVLPKWIHHVILGLVLSILVYSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTW 763
            ..:.:||.:..|:...:.:|:...|..|..:.:||.||.     |..:.|:||::|
pombe   685 FTKKMPKIVRVVVFISLYAIIAGVFIYFKDVTFGMHGPA-----SDFHRLRWLNSW 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	250/747 (33%)
		PMT	44..290	CDD:280519	85/245 (35%)
		MIR	318..374	CDD:197746	29/64 (45%)
		MIR	385..440	CDD:197746	24/54 (44%)
		MIR	446..501	CDD:197746	24/60 (40%)
		PMT_4TMC	518..763	CDD:292810	66/253 (26%)
ogm2	NP_594135.1	PMT1	34..739	CDD:224839	255/771 (33%)
		PMT	63..306	CDD:280519	85/244 (35%)
		MIR	332..385	CDD:197746	28/54 (52%)
		MIR	405..454	CDD:197746	24/48 (50%)
		PMT_4TMC	538..735	CDD:292810	66/253 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	168	1.000	Domainoid score	I918
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5297
Inparanoid	1	1.050	430	1.000	Inparanoid score	I326
OMA	1	1.010	-	-		QHG52910
OrthoFinder	1	1.000	-	-		FOG0002698
OrthoInspector	1	1.000	-	-		oto101681
orthoMCL	1	0.900	-	-		OOG6_101353
Panther	1	1.100	-	-	LDO	PTHR10050
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	1	1.000	-	-		X3468
TreeFam	1	0.960	-	-
	14	13.860