DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tw and ogm4

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_596807.1	Gene:	ogm4 / 2539761	PomBaseID:	SPBC16C6.09	Length:	778	Species:	Schizosaccharomyces pombe

Alignment Length:	827	Identity:	240/827 - (29%)
Similarity:	372/827 - (44%)	Gaps:	156/827 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TPKCPRRGSV-KDVAQNAPRTAPTSSKEANWNWWLLLATVFLVTFATRFYKVTEPDHICWDETHF 71
            |||.....|. :||:.|.........|.|     .:|.||  ::|.|||:.:..|..:.:||.||
pombe    33 TPKQKSPNSTEEDVSLNLKTLKAKKFKLA-----FVLITV--LSFITRFWNLNLPGEVVFDEVHF 90

  Fly    72 GKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKY--NETRYQGMRYFCTTLG 134
            ||..|:|:...:|||:|||..|:|:.|...|.||:|.:.|:..||.|  |...|..:|.:...|.
pombe    91 GKFASYYLQGKYFFDLHPPFAKLLLALVAKLAGYDGHYLFDNIGDNYKDNGVPYVTIRAWPALLS 155

  Fly   135 ALIMPMGF----DTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASVWGMVKV 195
            :|:.|:.|    ::.|||.    |.:::::.::||...:|..:.||||..|||.|:.:::..|:.
pombe   156 SLVPPVVFLIMKESGYDLL----ACIVSSSLVLFDNAHVTEGRLILLDATLLFSMVCAIYCYVRF 216

  Fly   196 SKSTASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDL--GQPILE 258
            .|...:  .:...||.|||.||..||||||.|:||.|..|.:||....||| .|.|:  |..:..
pombe   217 FKLRHT--PFSRPWWAWLFFTGFFLSCTISTKYVGFFTFLSIGLSVCLELW-YLWDIKTGLTVER 278

  Fly   259 TVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSL-YNASMPRDVA 322
            ..:....|...||.:|.|.::.:||:|.::|..||.||.|.|..||..|..|.: .|:::   :.
pombe   279 FFQHFLARFFCLIFFPFLFFLFWFYMHFNILTISGPGDSFMSLEFQETLSDNPITANSTI---LN 340

  Fly   323 YGSLVTIKNHKTGGGYLHSHHHLYP-------KGSGARQQQVTTYTHKDENNKWLIRPHNKPGPP 380
            |..:|||| |.....:||||...||       ..||.  ||||.|...||||.|:|.|.:...||
pombe   341 YYDIVTIK-HMGTNAFLHSHPEKYPIPYDDGRISSGG--QQVTGYQFDDENNYWMILPADHYDPP 402

  Fly   381 -KGKVQI-LRHGDLVRLTHMATRRNLHSHNEPAP----------------MTKKHLQVTGYGELG 427
             :.|:.: :::.|.::|.|:.|..:|.:|:..:|                ..||| :.|.: ::.
pombe   403 IEAKLNVPVKNMDYIKLHHVGTNTDLMTHDVASPYHPTNEEFTTVSVDESAGKKH-EYTLF-QVV 465

  Fly   428 LGDANDVWRVLIVGGKVNETVHTVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSCNPNVRDK 492
            :.|..|..|.|          :|..|..|.||.|.:.|:.|..|.||.|.|:|.|::...|::..
pombe   466 MSDNTDPQRPL----------YTKASSFKLIHKLTHVAMWSDPKPLPDWAFKQLEINGAKNIQTG 520

  Fly   493 NSQWNVED----NEHKLMPSVSFSVYAPGFFARFLESHAVMLQGNAGLKPKEGEVTSRPWQWPIN 553
            :..|..:|    .:.:|..........| |:.::||....|.:.| .:..:....:|.|..|...
pombe   521 SIFWTFDDIIGLKDSRLKKEKKIPKKLP-FWKKYLELQLTMFRQN-NMLTEFHPYSSNPSDWFTL 583

  Fly   554 YRGQFF---SGSSYRIYLLGNPLIWWSNLVFLALFVTVFLCNAVVQQRRAGFARSAAQNQAQVPD 615
            :.|..|   |..:.:|||||||:.||  ::...:..|..:..|.:..|:.|.
pombe   584 HHGIAFWAKSEENKQIYLLGNPIGWW--IIAGTVLSTTVVAAAEILLRQRGI------------- 633

  Fly   616 SETVAQDEESEHSTTDICSCCTPAKEIVPKAVPSGSPEAPNPAQSLRAAAWLFLGWMLHYLPFWA 680
                                     ..:|:.|.:         ...|:..:.::.::.|||||:.
pombe   634 -------------------------RTLPETVRN---------HFYRSTMFFYMTYVFHYLPFFI 664

  Fly   681 MGRVLYFHHYFPALIFNSLLTGVMYNYILR-----------VLPKWIH------------HVI-- 720
            |||.|:.|||.||.:..|||.|.......|           .:||.:.            |||
pombe   665 MGRQLFLHHYLPAHLAGSLLVGAFIQLACRKSFRSPVSAGVPIPKDVDEKGHSKCHRKYGHVIEL 729

  Fly   721 --LGLVLSILVYSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWEF 765
              ..|::.:::|.|..|:|:.||......:|    ....|||.:|.|
pombe   730 ICTLLLIFVVIYCFTFFAPMTYGDKSLSVDE----WTRRKWLDSWVF 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	230/791 (29%)
		PMT	44..290	CDD:280519	90/253 (36%)
		MIR	318..374	CDD:197746	25/62 (40%)
		MIR	385..440	CDD:197746	15/71 (21%)
		MIR	446..501	CDD:197746	18/58 (31%)
		PMT_4TMC	518..763	CDD:292810	62/274 (23%)
ogm4	NP_596807.1	PMT1	37..776	CDD:224839	237/823 (29%)
		PMT	63..310	CDD:280519	91/255 (36%)
		MIR	337..396	CDD:197746	25/64 (39%)
		PMT_4TMC	549..770	CDD:292810	62/274 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810