DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tw and SDF2L1

DIOPT Version :9

Sequence 1:	NP_001259102.1	Gene:	tw / 31024	FlyBaseID:	FBgn0086368	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_071327.2	Gene:	SDF2L1 / 23753	HGNCID:	10676	Length:	221	Species:	Homo sapiens

Alignment Length:	242	Identity:	76/242 - (31%)
Similarity:	115/242 - (47%)	Gaps:	45/242 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 WPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPRDVAYGSLVTIKN--HKTG 335
            |||||.:|     |::|...|               |.:...|.:   |..||::.:.|  |:.
Human    11 WPVLLGLL-----LALLVPGG---------------GAAKTGAEL---VTCGSVLKLLNTHHRV- 51

  Fly   336 GGYLHSHHHLYPKGSGARQQQVTTYTHKDE-NNKWLIRPHNKPGPPKGKVQILRHGDLVRLTHMA 399
              .||||...|  |||:.||.||.....|: |:.|.||..::.|.|:|..  :|.|..|||||:.
Human    52 --RLHSHDIKY--GSGSGQQSVTGVEASDDANSYWRIRGGSEGGCPRGSP--VRCGQAVRLTHVL 110

  Fly   400 TRRNLHSHNEPAPMTKKHLQVTGYGELGLGDANDVWRVLIVGGKVNETVHTVTSRLKFIHLLQNC 464
            |.:|||:|:.|:|::... :|:.:||.|.||..|:|.|...|.....     .:.::|.|:..:.
Human   111 TGKNLHTHHFPSPLSNNQ-EVSAFGEDGEGDDLDLWTVRCSGQHWER-----EAAVRFQHVGTSV 169

  Fly   465 ALTSSGKQL--PKWGFEQQEVSCNPNVRDKNSQWNVEDNEHKLMPSV 509
            .|:.:|:|.  |..|  |.||...|:....|: |...:... :.|||
Human   170 FLSVTGEQYGSPIRG--QHEVHGMPSANTHNT-WKAMEGIF-IKPSV 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tw	NP_001259102.1	PMT1	41..765	CDD:224839	76/242 (31%)
		PMT	44..290	CDD:280519	7/16 (44%)
		MIR	318..374	CDD:197746	22/58 (38%)
		MIR	385..440	CDD:197746	23/54 (43%)
		MIR	446..501	CDD:197746	13/56 (23%)
		PMT_4TMC	518..763	CDD:292810
SDF2L1	NP_071327.2	PMT_4TMC	<53..>200	CDD:330524	56/159 (35%)
SDF2L1	NP_071327.2	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	218..221
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2235
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840